The main methods of acute ischemic stroke treatment are thrombolysis and endovascular therapy. Our focus has been on investigating the use of computed tomography (CT) angiography and magnetic resonance imaging (MRI) and their relation to assess outcomes after acute reperfusion therapy. In addition, we examined peri-procedural management including blood pressure. Our current efforts are aimed at understanding the safety and efficacy of treatment of mild strokes with large artery occlusion.

Contact Person

M. Shazam Hussain, MD

Ken Uchino, MD



Addition of Hyperacute MRI Aids in Patient Selection, Decreasing the Use of Endovascular Stroke Therapy. Wisco D, Uchino K, Saqqur M, Gebel JM, Aoki J, Alam S, George P, Newey CR, Man S, Tateishi Y, McNeil J, Winfield M, Cheng-Ching E, Hui FK, Toth G, Bain M, Rasmussen PA, Masaryk T, Ruggieri P, Hussain MS. Stroke. 2014;45(2):467-72.

Diffusion-weighted imaging volume as the best predictor of the diffusion-perfusion mismatch in acute stroke patients within 8 hours of onset. Aoki J, Tateishi Y, Cummings CL, Cheng-Ching E, Ruggieri P, Hussain MS, Uchino K.  J Neuroimaging. 2015;25:217-25. [Epub 2014 Mar 4]

The Location of Pre-treatment Hyperdense Middle Cerebral Artery Sign Predicts the Outcome of Intra-arterial Thrombectomy for Acute Stroke. Man S, Hussain MS, Wisco D, Katzan I, Aoki J,  Tateishi Y, Cheng-Ching E, Hui F, Masaryk T, Rasmussen P, Uchino K. J Neuroimaging. 2015;25:263-8. [Epub 2014 Apr 7]

Early experience in high-resolution MRI for large vessel occlusions. Hui FK, Zhu X, Jones SE, Uchino K, Bullen JA, Hussain MS, Lou X, Jiang WJ. J Neurointerv Surg. 2015;7(7):509-16. [Epub ahead of print 2014 May 14]

Collateral Flow and Brain Changes on CT Angiography Predict Infarct Volume on Early Diffusion-weighted Imaging. Aoki J, Tateishi Y, Cumming CL,  Cheng Ching, E; Ruggieri P, Hussain MS, Uchino K. Journal of Stroke and Cerebrovascular Diseases. 2014;23(10):2845-50.

Intra-arterial therapy for acute ischemic stroke under general anesthesia versus monitored anesthesia care. John S, Thebo U, Gomes J, Saqqur M, Farag E, Xu J, Wisco D, Uchino K, Hussain MS. Cerebrovasc Dis. 2014;38(4):262-267.

Predictors of Infarct Growth after Endovascular Therapy for Acute Ischemic Stroke. Man S, Aoki J, Hussain MS, Wisco D, Tateishi Y, Toth G, Hui F, Uchino K. J Stroke Cerebrovasc Dis, 2014 Dec 11. [Epub ahead of print]

Initial Experience Using the 5MAX™ ACE Reperfusion Catheter in Intra-arterial Therapy for Acute Ischemic Stroke. John S, Hussain MS, Toth G, Bain M, Uchino K, Hui FK. J Cerebrovasc Endovasc Neurosurg. 2014 Dec;16(4):350-7.

Degree of Collaterals and not Time is the determining factor of Core Infarct Volume within 6 hours of Stroke Onset. Cheng-Ching E, Frontera JA, Man S, Aoki J, Tateishi Y, Hui FK, Wisco D, Ruggieri P, Hussain MS, Uchino K. AJNR. 2015 Apr 2. [Epub ahead of print]

Acute endovascular reperfusion therapy in ischemic stroke: a systematic review and meta-analysis of randomized controlled trials. Osanai T, Pasupuleti V, Deshpande A, Thota P, Roman Y, Hernandez AV, Uchino K.PLoS One. 2015;10(4):e0122806

Large deep white matter lesions may predict futile recanalization in endovascular therapy for acute ischemic stroke. Tateishi Y, Wisco D, Aoki J, George P, Katzan I, Toth G, Hui F, Hussain MS, Uchino K. Interv Neurol. 2015;3(1):48-55. PMID: 25999992

ASPECTS Discrepancies between CT and MRI Imaging: Analysis and implications for Triage Protocols in Acute Ischemic Stroke. Hui FK, Obuchowski N, Katzan I, Toth G, Wisco D, Cheng-Ching E, Uchino K, Man SM, Hussain MS. J NeuroInterventional Surgery. 2017;9(3):240-243. PMID: 26888953

Lower Intraprocedural Systolic Blood Pressure Predicts Good Outcome in Patients Undergoing Endovascular Therapy for Acute Ischemic Stroke. John S, Hazaa W, Uchino K, Toth G, Bain M, Thebo U, Hussain MS. Interv Neurol. 2016 Mar;4(3-4):151-7. [Epub 2016 Feb 25]. PMID: 27051411.

Timeline of blood pressure changes after intra-arterial therapy for acute ischemic stroke based on recanalization status. John S, Hazaa W, Uchino K, Hussain MS. J NeuroInterventional Surgery. 2017;9(5):455-458. [Epub ahead of print 2016 Apr 15]. PMID: 27084964.

Treatment of patients with mild acute ischemic stroke and associated large vessel occlusion. Cerejo R, Cheng-Ching E, Hui F, Hussain MS, Uchino K, Bullen J, Toth G. J Clin Neurosci. 2016;30:60-4.. [Epub ahead of print 2016 Apr 2] PMID: 27050916. PMID: 28872449

The Safety and Feasibility of Mechanical Thrombectomy for Mild Acute Ischemic Stroke With Large Vessel Occlusion.Toth G, Ortega-Gutierrez S, Tsai JP, Cerejo R, Al Kasab S, Uchino K, Hussain MS, Bain M, Bullen J, Samaniego EA. Neurosurgery. 2019. [Epub ahead of print 2019 Sep 9]. PMID: 31501905.

Members & Collaborations