Calcium channel blockers are a group of medications that limit how your body uses calcium. By slowing down how your cells use calcium, these medications can lower your blood pressure, prevent heart rhythm problems and more.
Calcium channel blockers are a group of medications that limit how your body uses the essential mineral calcium. Because your heart and circulatory system need calcium to function, these medications treat high blood pressure, heart rhythm problems and more.
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Calcium is an electrolyte, which means it has a positive charge when it’s dissolved in water. Your body uses ions (atoms with an electrical charge) in electrolytes to transport things into and out of your cells. Your body is always working to balance things out. That means when calcium ions enter a cell, sodium ions leave, and vice versa.
Those ions enter and exit your cells using channels, which act just like doorways to the inside of your cells. Those channels also have a type of security feature, which only allows ions that have the right type of charge (either positive or negative) and the right size to enter and exit.
Calcium channel blockers take advantage of the fact that certain types of calcium channels tend to exist only in certain parts of the body. This allows targeting of medications depending on which channels they affect.
There are many calcium channels on each of the cells in question. At the right dosage, calcium channel blockers (sometimes calcium channel antagonists) only block some — but not all — of them. That slows down those cells’ use of calcium because there are fewer ways to bring it inside.
Calcium channel blockers' main uses are to treat heart and circulatory conditions. In the United States, they’ve been previously approved to treat the following:
In addition to the officially approved uses, calcium-channel blockers are also frequently prescribed off-label. This means while the medications aren’t officially approved to treat a condition, there’s evidence that they can still safely do so. Off-label prescribing is a legal practice, and it’s medically acceptable so long as healthcare providers do so safely and responsibly.
Off-label uses of calcium-channel blockers include:
Studies are also looking at calcium channel blockers because they may help delay or prevent diseases that will be more severe if you have high blood pressure earlier in life. Those diseases include dementia, Parkinson’s disease and Alzheimer’s disease.
Calcium channel blockers are very commonly prescribed, especially for high blood pressure. Millions of adults in the United States receive a prescription for a calcium channel blocker each year.
Calcium channel blockers come in two main types.
|Clevidipine (in-hospital use only)||Verapamil (phenylalkamine)|
|Clevidipine (in-hospital use only)|
Calcium channel blockers have several advantages that make them commonly prescribed.
In general, the following side effects are possible with calcium channel blockers:
The most common side effects are:
These medications are more likely to cause:
Many calcium channel blockers can cause gingival hyperplasia, which is when your gums grow too much around your teeth. They may also cause an increase in symptoms of gastroesophageal reflux disease (GERD) or heartburn.
The dosing of calcium channel blockers is very important for them to be effective and safe. Because of that, if you miss a dose of one of these medications, you should never try to “catch up” by taking an extra dose, as even doubling your dose may be dangerous. This is especially true with verapamil, which strongly affects the timing and strength of your heartbeat, meaning it can be deadly if you take too much.
In general, patients who have certain types of heart problems or low blood pressure may not be able to take calcium channel blockers. Other reasons why you may not be able to take some of these medications include pregnancy, heart problems, liver problems, or certain types of irregular heart rhythms.
Calcium channel blockers can interact with many medications. This is especially true of any medication that lowers your blood pressure or affects your heart rate. You may also want to avoid taking calcium channel blockers with grapefruit (either the fruit or the juice) because it can affect how your body absorbs these medications.
In general, your healthcare provider or pharmacist is the best source of information on medication interactions. You shouldn’t hesitate to ask them if you have any questions about interactions.
In general, calcium channel blockers taken by mouth are safe for long-term use. In many cases, you can take them indefinitely. However, you should never stop taking them suddenly without talking to your healthcare provider.
In some cases — depending on why you take these medications — you may be able to improve your health to a point where you don’t need to take them any longer. One example of this is lowering your blood pressure through diet and exercise.
In those cases, you would need to talk to your healthcare provider and they can help plan a way to wean you off of calcium channel blockers. You should never stop these medications suddenly.
However, there are some conditions, such as arrhythmias or enlarged heart, where you would need to remain on calcium channel blockers (or another medication for that condition) indefinitely.
Your healthcare provider can advise you on when to call or schedule an appointment related to taking calcium channel blockers. In general, you should call or schedule an appointment if you have a sudden change in symptoms, especially ones related to your heart and circulatory system.
You should seek immediate medical care if you have any of the following symptoms:
You should also seek care immediately if you have any symptoms related to allergic reactions, including:
Last reviewed by a Cleveland Clinic medical professional on 01/07/2022.
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