Vasodilators are drugs that open your blood vessels. Your provider may prescribe vasodilators to treat high blood pressure, chest pain or heart failure. Most people take vasodilators as part of an overall treatment plan. To improve your heart health, you also need to eat a nutritious diet, exercise and manage stress.
Vasodilators are medicines that dilate (open) your blood vessels. Vasodilators keep your arteries and veins from narrowing or contracting (squeezing) shut.
You have two main types of blood vessels. Veins carry blood to your heart, while arteries carry blood from your heart to the rest of your body.
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
Vasodilation is blood vessel widening (or getting bigger). It occurs when the muscles in your blood vessel walls relax. When you take a vasodilator, the blood vessel’s middle interior (lumen) is the part that widens.
There are several types of vasodilator medications, and they all work slightly differently. Direct vasodilators directly affect the muscle cells that line your blood vessels. They make your muscle cells relax so that blood vessels open. Because they work quickly, they can cause more side effects. Healthcare providers use direct vasodilators when other treatments haven’t worked.
Other vasodilators control the chemicals that make your blood vessels expand or contract. They are effective but work more slowly.
Types of vasodilators include:
Healthcare providers may prescribe vasodilators to treat conditions that affect blood flow, including:
There are many vasodilator drugs. Your provider will recommend a medication that is right for you, depending on the underlying condition. You may need to try several types to find the right one.
A list of common vasodilators includes:
Vasodilators can be very effective for people with certain heart conditions. They are widely used treatments for high blood pressure.
Opening your blood vessels can:
Direct vasodilators are strong medicines. Typically, healthcare providers only prescribe them when other treatments have failed to control symptoms.
Direct vasodilators may cause more severe side effects than other types of vasodilators. Sometimes, these side effects are severe enough that you need other medicines to treat the side effects. For example, a vasodilator may cause water retention, which can raise pressure and lead to congestive heart failure. You may need to take a diuretic to help your body release the additional fluid.
Some types of vasodilators cause more severe effects, and the effects can vary from person to person. You and your provider may need to try several medicines to find one that works well with the fewest side effects. When you take vasodilators, you may have:
Vasodilators are not the only way to open blood vessels. Some other factors that cause vasodilation include:
Some herbs or supplements can also help with vasodilation. Some supplements have adverse medication reactions, so speak with your provider before taking any herb or supplements. Vasodilator supplements may include:
Ask your provider about possible food or drug interactions if you are taking vasodilators. It’s important to be honest and thorough when telling your provider what medications or supplements you take.
Some vasodilator interactions to watch for include:
How long you need to take vasodilators depends on what condition the medicine is treating. For example, if you take vasodilators to treat preeclampsia, you may stop taking the drug after you give birth. But if you have a chronic condition such as pulmonary hypertension, your provider may keep you on vasodilators long-term.
Sometimes, you can manage chronic conditions through lifestyle changes. For example, you may lower your blood pressure by losing weight and exercising regularly. Your provider will monitor any chronic conditions and guide your treatment options.
Vasodilators are not right for everyone. Ask your cardiologist (heart doctor) if you are a good candidate for vasodilator drugs. Generally, you may not be able to take certain types of vasodilators if you are pregnant or have:
For most people, vasodilators are one part of an overall heart treatment plan. You can keep your heart healthier by adopting healthy lifestyle habits. You may:
A note from Cleveland Clinic
Vasodilators are medications that open your blood vessels. Your healthcare provider may prescribe vasodilators to treat certain heart conditions, such as high blood pressure or CHF. Although vasodilators work well, they may cause some side effects. Tell your provider if you have dizziness, fatigue or headaches. You might take vasodilators short-term. Or you may need to keep taking the medication to manage a long-term condition.
Last reviewed by a Cleveland Clinic medical professional on 06/09/2022.
Learn more about our editorial process.