Trigeminal Neuralgia (TN)

Trigeminal neuralgia is a chronic condition that can cause sudden, intense painful episodes, typically on one particular side of your face, that can disrupt daily activities. Surgical procedures usually only suppress symptoms for a set amount of time, but other forms of medication can help relieve these short, sporadic, very painful episodes.


Side view of a face showing the trigeminal ganglion in the brain and areas the three branches (ophthalmic, maxillary and mandibular) cover.
Irritation of your trigeminal nerve cause trigeminal neuralgia. This nerve has three branches that provide sensory information to different areas of your face.

What is trigeminal neuralgia?

Trigeminal neuralgia, also referred to as tic douloureaux, is a condition defined by intense facial pain that can disrupt your normal, everyday activities. Activities as simple as chewing, talking, smiling, brushing your teeth or shaving can trigger brief bouts of intense pain. Though these painful episodes are short-lived, the pain can return sporadically (on and off). Or you might also experience constant pain that isn’t as severe.

Typically, trigeminal neuralgia is unilateral (meaning it only affects one side of your face). If it’s bilateral, both sides will be affected, though not at the same time. Bilateral trigeminal neuralgia is also very rare. Interestingly, the right side of the face is usually more affected by this condition than the left.


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What is the trigeminal nerve?

The trigeminal nerve is one of 12 pairs of nerves attached to your brain. It’s responsible for transmitting touch and pain sensations from your face and head to the brain. There are three branches in the trigeminal nerve, all of which are responsible for transmitting nerve impulses to different parts of your face:

  • The ophthalmic branch. The top portion of your face, including your forehead.
  • The maxillary branch. Everything in the middle of your face, including your cheeks, nostrils and upper lip.
  • The mandibular branch. The lower portion of your face, including your lower lip and jaw area.

What are the two main types of trigeminal neuralgia?

There are two main forms of trigeminal neuralgia:

  • Typical (Type 1) trigeminal neuralgia. You’ll likely experience painful episodes that are sharp, intense and sporadic. You may feel pain and/or a burning sensation all over your face that can last anywhere from a few seconds to two minutes. Though there will be pain-free breaks in between episodes, this can continue for up to two hours.
  • Atypical (Type 2) trigeminal neuralgia. This will be less painful and intense but more widespread. You’ll likely feel constant pain, notably stabbing and/or burning sensations, along with persistent aches and pains. With atypical trigeminal neuralgia, you may have more difficulty controlling the symptoms.

How common is trigeminal neuralgia?

About 150,000 people each year are diagnosed with trigeminal neuralgia. That’s roughly 4.3 new cases per 100,000 people. Trigeminal neuralgia affects people over the age of 50 significantly more than it does people under the age of 40, where it’s considered rare. This condition also affects women more than men and is considered a rare disorder.

Is trigeminal neuralgia related to MS?

About 1 to 2% of people with multiple sclerosis (MS) also have trigeminal neuralgia. MS and trigeminal neuralgia both slowly break down the body’s main protective layer around the nerve (the myelin sheath), which is why there’s a slight overlap. MS patients can also develop trigeminal neuralgia after their MS diagnosis. Similarly, any 40-and-under trigeminal neuralgia patients are considered candidates to develop MS. So, if you fall in this age range, you should consider getting tested for MS.


Symptoms and Causes

What causes trigeminal neuralgia?

There are several conditions that may cause trigeminal neuralgia, but it’s typically caused by a blood vessel exerting pressure on the nerve near your brain stem. MS causes the deterioration of the nerve coating called the myelin sheath, so people with MS may also develop TN.

This condition can also be caused by a tumor or lesion that compresses your nerves, though this isn’t nearly as common. If you damage your trigeminal nerve through oral or sinus surgery, a stroke or from facial trauma, you may feel facial nerve pain that’s similar to the symptoms of trigeminal neuralgia.

Some cases of trigeminal neuralgia are idiopathic — meaning no specific cause is identified.

What are the symptoms of trigeminal neuralgia?

Certain symptoms are contained to the cheek and jaw area, including:

  • Numbness and/or a tingling sensation.
  • Short bursts of severe pain.
  • Regular aches and pains.

Other symptoms include:

  • Short-term jolts of pain; a stabbing or electrical type feeling.
  • Out-of-nowhere episodes brought on by simple activities like chewing or talking.
  • A burning sensation all over one side of the face.

Which activities most commonly trigger trigeminal neuralgia?

It’s mostly simple activities that require you to move or touch your face that can trigger painful episodes, including:

  • Touching your face for any reason (shaving, putting on makeup, washing your face).
  • Eating and drinking.
  • Brushing your teeth, flossing and using mouthwash.
  • Talking and smiling.
  • Applying any impact or pressure to your face, especially to your cheek or jawline.
  • When a strong gust of wind or a breeze blows in your face.

Diagnosis and Tests

How is trigeminal neuralgia diagnosed?

Your doctor will ask you about your symptoms and medical history, while also performing a physical exam of your head and neck area, including your ears, mouth, teeth and temporomandibular joint (TMJ). They will likely make their diagnosis based on a few different factors:

  • The specific type of pain you’re feeling.
  • The exact spot on your face where you feel pain.
  • Which activitiesor actions trigger a painful episode.

The doctor may also conduct a neurological exam, which will likely consist of examining how the nerves in your brain and your motor system function, along with assessing your reflexes and pain tolerance.

There are a lot of conditions and disorders where facial pain is the main symptom, so it’s important to rule out these various, other conditions to determine your diagnosis. Conditions that can mimic trigeminal neuralgia include cluster headaches or migraines, post-herpetic neuralgia (pain following an outbreak of shingles) and TMJ disorder. It’s also important to rule out sinusitis and ear infections.

Your doctor may use a magnetic resonance imaging (MRI) scan to rule out brain tumors, MS and other potential causes. The scan can show whether there’s a blood vessel pressing on the nerve that is causing pain.

Is there any way to prevent trigeminal neuralgia?

Unfortunately, trigeminal neuralgia isn’t preventable. But you can prevent painful episodes by avoiding certain activities that cause severe, intense pain. There’s also nothing to suggest that trigeminal neuralgia is brought on by stress.

Management and Treatment

How is trigeminal neuralgia treated?

Trigeminal neuralgia symptoms can be treated with a combination of medications, surgery and complementary therapies.


  • Anticonvulsant drugs. Carbamazepine is typically the first choice for treating pain associated with trigeminal neuralgia. Your healthcare provider may also prescribe other anticonvulsant drugs, including oxcarbazepine, phenytoin, lamotrigine, sodium valproate, gabapentin, clonazepam and topiramate. If you’ve been taking one of these medications and feel that it isn’t helping as much as it should, you can ask your doctor to increase the dose or you can try another form of medication. While these anticonvulsant drugs can help relieve pain, there are some side effects, including dizziness, nausea, confusion and drowsiness.
  • Tricyclic antidepressants. Amitriptyline or nortriptyline are the most common medications in this category, and are generally used to treat Type 2 trigeminal neuralgia symptoms.
  • Muscle relaxants. Baclofen can be used alone or together with carbamazepine or phenytoin.
  • Other medications. A botulinum toxin injection may be used to block sensory nerves. In some instances, nerve blocks are used to provide temporary relief.


If you don’t respond to any of these medications or believe your condition is worsening over time, you could be a candidate for surgery. You have several different surgical options. Your doctor will likely recommend one for you based on the severity of your pain, your preference, your physical health, previous surgeries and the surgery’s relative risks and benefits. Additionally, it’s more difficult to perform surgery on those suffering from Type 2 trigeminal neuralgia.

Percutaneous (through the skin) surgical techniques include:

  • Balloon compression. The surgeon will insert a tube, called a cannula, through your cheek, up to the trigeminal nerve. From there, they insert a catheter with a small balloon through the tube. They inflate the balloon, compressing the nerve and damaging the pain-causing fibers. The provider removes the balloon and catheter at the end of the procedure. This procedure has been known to relieve symptoms for one to two years, though it can cause some numbness in the face.
  • Glycerol injection rhizotomy. The surgeon will inject glycerol through a needle into the nerve center, right where it splits into three branches. By injecting glycerol into the root of the trigeminal nerve, this procedure causes selective nerve damage that disrupts the body’s ability to transmit pain signals to the brain. This procedure can suppress pain for one to two years, though it can be performed multiple times. This procedure can also cause some facial numbness, as well as tingling.
  • Radiofrequency thermal lesioning. The surgeon will insert a needle through your cheek, all the way through to the base of your skull, which they’ll then use to send an electrical current to identify the specific pain point on the trigeminal nerve. They will then apply heat to the nerve until a lesion forms, destroying some of the nerve fibers. About half of patients who opt for this procedure see their symptoms return after three to four years. You may also feel facial numbness as a result of this procedure.

Microvascular decompression is a more invasive surgical procedure. It’s typically the most successful of all these procedures, as it can provide pain relief for up to 10 years (over 70% of patients have seen some sort of relief of their symptoms). The goal of this procedure is to provide a longer-term solution, where the trigeminal nerve can recover and return to a more normal, pain-free state. However, it's invasive because the surgeon must create an opening behind the ear, thus exposing the trigeminal nerve root. This opening reveals the blood vessel that may be compressing the nerve; once your surgeon identifies the specific blood vessel, they place a cushion between the nerve and the blood vessel. Younger patients who are otherwise in good health are suitable candidates for this procedure.

If a surgeon attempts to perform microvascular decompression but doesn’t find a blood vessel actively pressing against the nerve, they may perform a neurectomy. This is a procedure in which the surgeon cuts either part of the nerve near the brain stem or some of the nerve’s branches in the face. A neurectomy can have lasting side effects, including numbness in the areas where the surgeon cut part of the nerve and impaired hearing. Nerves in the face, however, can grow back over time, meaning the pain will return in that specific area as well.

Stereotactic radiosurgery uses Gamma Knife, CyberKnife or LINAC surgery to deliver a highly concentrated amount of radiation on the trigeminal nerve root, where it meets the brain stem. After this procedure, a lesion will form on the nerve that will disrupt its ability to transmit pain signals to the brain, though you may increasingly feel numbness in your face as a result. It can be a few weeks before you begin to see the effects of this procedure. Stereotactic radiosurgery generally eliminates symptoms for about three years.

Complementary therapies

There are other approaches you can use with drug therapy, including:

  • Yoga.
  • Creative visualization.
  • Meditation.
  • Aromatherapy.
  • Low-impact exercise.

Additional therapies that may be helpful include:

  • Acupuncture.
  • Chiropractic.
  • Supportive counseling or therapy.
  • Biofeedback.
  • Vitamin therapy.
  • Nutritional therapy.

Outlook / Prognosis

Does trigeminal neuralgia get worse over time?

It certainly can. At first, the pain may be limited to the jaw area, which leads some with this disorder to think that it’s just a routine dental problem. But over time, the condition can get worse and worse, to the point that the pain-free moments between episodes become shorter and shorter, sometimes until they’re nonexistent. Additionally, the intensity of your pain may increase, making normal activities a burden and forcing you to eliminate simple, everyday tasks from your routine, for fear of an attack. Pain management can also be less effective over time.

A note from Cleveland Clinic

Trigeminal neuralgia isn’t life-threatening but it can be life-altering. You may become afraid of performing certain normal activities, as they can bring on short, intense painful episodes. But, thankfully, there are different surgical procedures and treatment options that can help you live a normal, relatively pain-free life — even if this is a condition that will likely be present, in some way, for your entire life.


You can learn more by taking Cleveland Clinic's Trigeminal Neuralgia Online Risk Assessment.

Medically Reviewed

Last reviewed by a Cleveland Clinic medical professional on 10/25/2021.

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