The Section of Invasive and Interventional Cardiology offers cutting-edge diagnostic tests and nonsurgical interventional treatments for patients presenting along the entire spectrum of cardiac and cardiovascular disease. Coronary angiography was developed at Cleveland Clinic in 1958 by F. Mason Sones, MD, and the physicians, nurses, and technicians who carry on this rich tradition today are highly experienced in caring for the patients who are referred to the section.

For patients with coronary artery disease (CAD) who require an invasive evaluation, our physicians often perform intravascular imaging and/or flow-based physiologic evaluation to better understand what lesions require further treatment. In addition to routine percutaneous coronary intervention (PCI), our doctors are comfortable with the adjunctive use of ventricular support devices when necessary and some specialize in opening vessels that are chronically occluded (CTO). Further, the Cleveland Clinic is among very few centers nationally that can provide intracoronary brachytherapy (radiation) for in-stent restenosis.

For patients with structural cardiac disease (disease of the heart valves, walls, etc), our team is comprised of national and international leaders in transcatheter valve repair and replacement techniques, paravalvular leak closure, left atrial appendage occlusion, closure of patent foramen ovale (PFO) and atrial septal defect (ASD), and other necessary interventions. Patients with congenital heart disease including those with prior corrective congenital surgeries are also cared for in the section and have options of valve replacement, baffle dilation and stenting, and others.

For patients with peripheral artery disease, carotid stenting, atherectomy and stenting for lower extremity arterial disease (that may cause pain or non-healing wounds), and are some of the important options for patients provided in the section.

We are fortunate to have teams of physicians, advanced practice nurses and physician assistants, nurses, and technicians who have a great deal of experience in taking care of patients who present to the Section of Invasive and Interventional Cardiology.


The following is a small selection of current articles from the Section of Invasive and Interventional Cardiology:

  • Singh AD et al. Recurrent drug eluting stent in-stent restenosis: A state-of-art review of pathophysiology, diagnosis and management. Cardiovasc Revasc Med. 2020;S1553-8389(20)30014-2.
  • Mack MJ et al. Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients. N Engl J Med. 2019;380(18):1695–1705.
  • Huded CP et al. Incremental Prognostic Value of Guideline-Directed Medical Therapy, Transradial Access, and Door-to-Balloon Time on Outcomes in ST-Segment-Elevation Myocardial Infarction. Circ Cardiovasc Interv. 2019;12(3):e007101. 
  • Kapadia SR et al. Stroke After Surgical Versus Transfemoral Transcatheter Aortic Valve Replacement in the PARTNER Trial. J Am Coll Cardiol. 2018;72(20):2415–2426. 
  • Donnellan E et al. Outcomes of Patients With Mediastinal Radiation-Associated Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. Circulation. 2018;138(16):1752–1754. 
  • Stone GW et al. Transcatheter Mitral-Valve Repair in Patients with Heart Failure. N Engl J Med. 2018;379(24):2307–2318. 
  • Krishnaswamy A, Kapadia SR. Minimizing Stroke and Mortality Risks in Coronary RevascularizationJ Am Coll Cardiol. 2018;72(4):399–401. 
What We Treat

What We Treat

The Section of Invasive and Interventional Cardiology offers the latest, most technologically advanced diagnostic tests and catheter based treatments for atherosclerosis, heart valve disease, adult congenital heart disease and peripheral artery disease.

Diagnostic testing includes:

Interventional (catheter-based) procedures include:

Why choose Cleveland Clinic for your care?

Cleveland Clinic's Section of Invasive and Interventional Cardiology is a regional, national, and international referral center for catheter-based interventions, performing over 11,000 procedures each year. We are fortunate to have teams of physicians, advanced practice nurses and physician assistants, nurses, and technicians who have a great deal of experience in taking care of patients who present to the Section of Invasive and Interventional Cardiology. With our long record of practice-changing research and innovation, we often have the opportunity to provide patients with catheter-based treatment options that are still in trial and not widely available. We look forward to meeting you and participating in your care.

Learn about our outcomes





What to Expect

Whether you are coming from around the corner or around the world, you want to know what to expect before, during and after your visit with us. If you have any questions while reviewing this information, please contact us. We are happy to answer any questions you may have.

By Phone

Call Toll-free 800.223.2273, ext. 46697 or submit an online request.


Go to Desk J2 - 3, 9500 Euclid Avenue, Cleveland, Ohio.


Use our secure online form to submit an appointment request 24/7. We will receive it and follow-up with you as soon as possible.

Physician Referrals

Mon. - Fri., 8 a.m. - 5 p.m. (ET):
toll-free 800.223.2273, ext. 49162



Cleveland Clinic Heart, Vascular & Thoracic Institute physicians, surgeons, and researchers continue to research into new treatments and therapies with the goal of improving patient care and outcomes into the future.

Clinical Trials

Clinical trials (or research studies) help us create the medicine of tomorrow. They provide hope through offering testing of new drugs, new surgical techniques or other treatments before they are widely available.

We can help you access hundreds of clinical trials across all specialty areas. Our searchable online trials tool makes identifying treatment opportunities easier than ever.

Heart, Vascular & Thoracic Institute