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Gastroparesis can cause difficulty eating.


Feeling full after just a few bites? Frequent nausea or vomiting? Unexplained weight loss? Sometimes an upset stomach or heartburn is more than it seems.

When you have delayed gastric emptying (gastroparesis), these symptoms are all too common. And the disorder doesn’t just cause physical symptoms. You might feel anxious or depressed. Maybe you avoid social situations that involve food, especially when you’re not sure why you feel so sick.

Cleveland Clinic’s skilled, compassionate healthcare providers understand the pain and frustration digestive issues cause. We regularly treat people with gastroparesis and undiagnosed gastrointestinal (GI) symptoms. And we’re here to help you get relief with personalized treatment and support that focuses on your health and well-being.

Why Choose Cleveland Clinic for Gastroparesis Care?

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Demonstrated expertise:

Cleveland Clinic is a national leader in endoscopic therapy for gastroparesis and provides patients with access to surgeons that specialize in gastroparesis-related surgeries. Our Gastroparesis Clinic was one of the first programs nationally, providing coordinated surgical and gastroenterology appointments on same day, and in the same location.
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Minimally-invasive options:

We specialize in endoscopic and laparoscopic treatments, including per-oral pyloromyotomy and gastric electrical stimulation. These minimally invasive procedures relieve gastroparesis symptoms without open surgery.

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Personalized care:

You’ll meet one-on-one with a provider who specializes in treating gastroparesis to discuss your medications, diet, nutrition and other treatments in your personalized care plan. We’ll take the time to answer your questions so you understand what’s happening every step of the way. Meet our team.

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Virtual visits:

Stomach problems can sometimes make it hard to leave the house. We offer virtual visits for some appointments, so you can meet with your providers from the comfort of your home. All you need is an internet connection and a smartphone, tablet or computer.

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National recognition:

Cleveland Clinic is a trusted healthcare leader. We're recognized in the U.S. and throughout the world for our expertise and care.

Gastroparesis Diagnosis at Cleveland Clinic

Choosing Cleveland Clinic for your gastroparesis diagnosis and treatment means you can get care from healthcare providers from multiple specialties — all under one roof. Your experienced care team could include:

Diagnosing gastroparesis can be difficult since the symptoms are often similar to those of other digestive disorders. As part of your initial evaluation, we do a thorough and complete workup of your entire gastrointestinal tract to make sure that gastroparesis is the real issue. Our team will want to rule out:

You’ll start your diagnosis process with a physical exam. When you come to your appointment, be prepared to answer questions about your eating habits, diet and medical history. It’s important to let your provider know if you’ve had GI surgery in the past or have other health conditions like diabetes.

Your provider will also look for signs of malnutrition. They’ll talk with you about your symptoms and how they affect your life. And you can also expect them to press down on your belly (abdomen) to check for swelling or tenderness.

Next, we’ll use a combination of routine and advanced tests to get to the bottom of your GI problems and confirm that you have gastroparesis. This can include:

Lab tests

Blood and urine tests tell your healthcare provider if you have malnutrition or dehydration from your GI issues. They’ll also look for signs of an infection or hyperglycemia (high blood sugar), which can trigger gastroparesis.

Upper GI series

An upper GI series uses fluoroscopy, a type of X-ray, to examine your esophagus, stomach and small intestine. You’ll drink barium (a white substance visible on X-rays) so that your provider can see how the barium moves through your digestive tract. It simulates how food would move through it when you eat.

Upper endoscopy

Your provider will insert an endoscope (thin, flexible tube with a camera) into your mouth and down your throat to look for blockages, inflammation or damaged tissue in your upper GI tract. Your provider will sedate you during the procedure. While an endoscopy is more invasive than a fluoroscopy, it shows more detail.

Gastric emptying studies

You’ll need to take a test that measures how well your stomach empties its contents into your small intestine. During a gastric emptying solid study, you eat a meal that contains a safe, radioactive isotope (tracer). We do imaging scans over a few hours, starting with one minute after you eat and again at one, two and four hours. This lets us see how the tracer moves through your digestive tract.

Or we may ask you to swallow a wireless motility capsule called a SmartPill™. The pill contains a tiny electronic device that sends information to an electronic recorder to show how quickly food travels through your digestive system.


Our healthcare providers see patients at convenient locations throughout Northeast Ohio, Florida and London.

Gastroparesis Treatment at Cleveland Clinic

We offer a wide range of gastroparesis treatments at Cleveland Clinic. We’ll personalize your treatments to you, your symptoms and your lifestyle so you can feel better as quickly as possible.

Minimally invasive gastroparesis treatment

We always try to do the least invasive treatment options first rather than moving right to talking about surgery. These could include things like:

  • Diet changes: A registered dietitian works with you to adjust your diet and eating habits. We’ll help you maintain a healthy weight and avoid malnutrition. We may recommend eating frequent, small meals instead of two or three large meals each day. It’s important to make sure that these meals include high-fiber, high-calorie foods that are low in fat. Light activity after a meal, like walking, can also help digestion.
  • Medication: Some medications, like metoclopramide, domperidone, cisapride or erythromycin, can help your stomach work better so its contents move into your small intestine faster. Other medications called antiemetics can ease your nausea and vomiting. If you have gastroparesis and diabetes, insulin can help maintain your blood glucose levels.
  • Injections: We may inject botulinum toxin (Botox®) directly into your pylorus (the valve between your stomach and small intestine). Intrapyloric injections relax the muscle in this valve so your stomach can more easily empty its contents.
  • Feeding tube or intravenous (IV) nutrition therapy: We may insert a tube in your nose or mouth to deliver a nutrient- and calorie-rich liquid directly to your small intestine, bypassing your stomach (enteral nutrition). Sometimes, we deliver nutrients through an IV needle in your arm (parenteral nutrition). These therapies are only for people who can’t get enough calories and nutrients by eating solid food.

Gastroparesis surgery

Gastroparesis surgery may be right for you if your symptoms don’t improve after you change your diet or take medication. At Cleveland Clinic, we specialize in an innovative, minimally invasive procedure called per-oral pyloromyotomy (POP).

During POP, we’ll insert an endoscope into your mouth and move it through your esophagus to your pylorus. We’ll open your pylorus with a small cut so food can better exit your stomach. POP doesn’t require a large incision in your belly, so you can recover faster and with less pain. Some people go home the same day as their procedure.

In addition to POP, we offer a range of other gastroparesis surgeries. Your provider will discuss each procedure’s risks and benefits with you before making a recommendation. Depending on your condition, surgical treatment may include:

Taking the Next Step

When eating makes you so sick that you don’t want to leave the house, it can take a physical and emotional toll on you — and limit your quality of life. Our experts are here to guide and support you through gastroparesis diagnosis and treatment every step of the way. We want you to get back to feeling like yourself again — and enjoy meals and fun times with your favorite people.

Getting an appointment with Cleveland Clinic’s gastroparesis experts is easy. We’re here to help you get the care you need.


Getting an appointment with Cleveland Clinic’s gastroparesis experts is easy. We’re here to help you get the care you need.

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