Leonard Calabrese, DO
Primary Location
Cleveland Clinic Main Campus
- Appointment:
- 216.444.5632
- Desk:
- 216.444.5258
- Fax:
- 216.636.7604
Additional Locations
Treatment & Services
- Administration of Injectable Medications for Osteoporosis
- Adult Rheumatology
- Bone Density Testing
- Clinical Trials
- Cortisone Injections
- Dual Energy X-Ray Absorptiometry (DXA)
- General Rheumatology
- Hyaluronic Acid (HA)
- Hyaluronic Acid Injections
- Immunoglobulin Infusion
- Immunology
- Immunotherapy
- Infusion Therapy
- Infusions of Biologic Agents on Site
- Joint Aspiration
- Joint Injections
- Joint Preservation Center
- Medical Management of Early Osteoarthritis
- Medication Management
- Musculoskeletal Evaluation
- Musculoskeletal Medicine
- Musculoskeletal Treatment for Joint Pain
- Osteoporosis Diagnosis
- Rheumatoid Arthritis: How to Treat
- Rheumatology
- Therapeutic Injections
- Ultrasound-Guided Procedures
- Viscosupplementation
Specialty in Diseases & Conditions
- Ankylosing Spondylitis
- Antiphospholipid Syndrome
- Arthritis
- Arthritis of the Elbow
- Arthritis of the Hip
- Arthritis of the Knee
- Arthritis of the Shoulder
- Arthritis of the Thumb Base
- Autoimmune Disease
- Autoinflammatory Syndromes
- Behcet's Disease
- Benign Hypermobility Joint Syndrome
- Buerger's Disease
- Bursitis
- Calcification Tendinitis
- Calcinosis
- Central Nervous System Vasculitis
- Chondrocalcinosis (Pseudogout)
- Churg-Strauss Syndrome
- Connective Tissue Diseases
- Connective Tissue Disorders
- Cryoglobulinemia
- Dermatomyositis
- Familial Mediterranean Fever (FMF)
- General Infectious Diseases
- Giant Cell Arteritis
- Gout
- Gout Arthritis
- Granulomatosis with Polyangiitis (Wegener’s)
- Hand Pain
- Hand Problems
- Henoch-Schonlein Purpura
- Hepatitis B
- Hepatitis C
- Hip Disorders
- Hip Pain
- Immunodeficiency
- Immunosuppression
- Iritis
- Joint Pain
- Knee Joint Disorders
- Knee Pain
- Lupus
- Lupus Anticoagulant
- Lupus Nephritis
- Metabolic Bone Disease
- Metabolic Diseases
- Microscopic Polyangiitis (MPA)
- Musculoskeletal Disorders
- Musculoskeletal Impairments
- Musculoskeletal Pain
- Myositis
- Osteoarthritis
- Osteoarthritis of the Hips in the Elderly
- Osteoarthritis of the Knees in the Elderly
- Painful Joints
- Palindromic Rheumatism
- Panuveitis
- Polyarteritis Nodosa
- Polymyalgia Rheumatica
- Polymyositis
- Pseudogout
- Psoriatic Arthritis
- Radiculopathy
- Raynaud's Phenomenon
- Reactive Arthritis
- Relapsing Polychondritis
- Retroperitoneal Fibrosis
- Rheumatoid Arthritis
- Rheumatoid Arthritis and Heart Disease
- Sacroiliitis
- Sarcoidosis
- Scleritis
- Scleroderma
- Shoulder Pain
- Sjogren's Syndrome
- Spondylitis
- Spondyloarthropathy
- Spondylosis
- Steroid-Induced Osteoporosis
- Systemic Autoimmune Diseases
- Systemic Lupus Erythematosus
- Tendinosis
- Tendonitis
- Tenosynovitis
- Trigger Finger
- Vasculitis
Insurance
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View All PlansAbout Leonard Calabrese, DO
Leonard H. Calabrese, DO, heads Cleveland Clinic's Section of Clinical Immunology and manages its Clinical Immunology Clinic. He specializes in diseases of the immune system -- in particular, immunodeficiency diseases, such as human immunodeficiency virus (HIV) and other chronic viral infections, which are the subject of both clinical care and investigation. Dr. Calabrese is also Co-director of the Center for Vasculitis Care and Research and has a particular interest in vascular inflammatory disease of the central nervous system.
A graduate of the Kansas City University of Medicine and Biosciences , Dr. Calabrese performed his internal medicine training at Cleveland Clinic in Ohio, followed by a fellowship in rheumatic and immunologic disease. He has been a staff member in Cleveland Clinic's Department of Rheumatic and Immunologic Diseases since 1980.
Recipient of numerous awards and honors, Dr. Calabrese has received an honorary Doctorate of Humane Letters from the Kansas City University of Medicine and Biosciences, the Phillips Medal of Public Service from the Ohio University College of Osteopathic Medicine, the Bruce Hubbard Stewart Award for humanitarianism and Leonard Tow Humanitarianism in Medicine award from the Arnold P Goldman MD Foundation. He holds the R.J. Fasenmeyer Chair of Clinical Immunology and is the director of the RJ Fasenmyer Center for Clinical Immunology. When he was awarded the Theodore F. Classen, DO Chair in Osteopathic Research and Education in 2008 he became the first dual-chair holder in Cleveland Clinic history.
Dr. Calabrese is a member of many professional societies, including the American Association of Immunology, Clinical Immunology Society and the International AIDS Society and the American Osler Society. He is a fellow of the American College of Rheumatology, American College of Physicians and the American College of Sports Medicine.
Dr. Calabrese has lectured nationally and internationally on the subjects of HIV, immunology and rheumatology and is the author of more than 300 published peer-reviewed articles, book chapters and reviews.
Education & Professional Highlights
Appointed
1980
Education & Fellowships
Fellowship - Cleveland Clinic
Immunologic Disease
Cleveland,
OH
1980
Residency - Cleveland Clinic
Internal Medicine
Cleveland,
OH
1978
Internship - Cleveland Clinic
Internal Medicine
Cleveland,
OH
1976
Medical Education - Kansas City University of Medicine and Biosciences University of Health Sciences College of Osteopat
Kansas City,
MO
1975
Undergraduate - John Carroll University
University Heights,
OH
1971
Professional Highlights
- R.J. Fasenmeyer Chair of Clinical Immunology
- Theodore F. Classen, DO Chair in Osteopathic Research and Education
Certifications
- Internal Medicine
- Internal Medicine - Rheumatology
Specialty Interests
Vasculitis, HIV/AIDS, Rhematic aspects of viral infections Vasculitis, HIV/AIDS, Hepatitis C
Awards & Honors
- Honorary Doctorate of Humane Letters, Kansas City University of Medicine and Biosciences
- Bruce Hubbard Stewart Award for humanitarianism
- Phillips Medal of Public Service, Ohio University
Memberships
- American College of Physicians
- American College of Rheumatology
- American Osler Society
- Clinical Immunology Society
Research & Publications
See publications for Leonard Calabrese, DO.
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)
Industry Relationships
Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.
To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.
As of 8/2/2024, Dr. Calabrese has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.
Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.
* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.
39 Patient Satisfaction Reviews
The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.
| Overall | Star Ratings | |
|---|---|---|
| Explains | 4.9 | |
| Courtesy, Respect & Concern | 4.9 | |
| Patient Rating of Doctor | 4.9 |
11 Patient Comments
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Reviewed on Apr 1, 2025
Dr. Leonard Calabrese is an exceptional physician and person.
Reviewed on Apr 1, 2025
I do love seeing Dr. Calabrese in person, but I enjoy the flexibility of the telemedicine as I live in Erie, PA.
Reviewed on Dec 31, 2024
Dr. Calabrese is simply tremendous. I appreciate him and trust him completely with my care.
Reviewed on Dec 31, 2024
Dr. Calabrese listens and gives very thoughtful responses. He is encouraging.
Reviewed on Oct 2, 2024
Dr calabrese was thorough with a professional yet personal demeanor
Reviewed on Oct 1, 2024
I am always, always, pleased with Dr. Calabrese and his level of care. I never feel he "poo poos" me. He listens and provides research-based input.
Reviewed on Jul 23, 2024
Dr. Calabrese always makes me feel comfortable with my treatment and options (which is why I opt to pay out of pocket for the visit because he's no longer in my network).
Reviewed on Jul 9, 2024
My appointments and visits are always handled in a first-rate manner with Dr Calabrese's Office.
Reviewed on May 28, 2024
Dr Calabrese is a phenomenal physician. He is an expert is his field, yet compassionate to his patients, he truly cares. The very best!
Reviewed on May 7, 2024
Excellent care, knowledgable, caring, explained things, took time, personable. Have seen doctor for 25 years, excellent relationship
Reviewed on Apr 16, 2024
I am very grateful to be a patient of Dr. Calabrese & Nurse Betsy! They are always very kind and caring. They answer all of my questions and explain things in terms I can understand.