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Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Administration of Injectable Medications for Osteoporosis
  • Adult Rheumatology
  • Bone Density Testing
  • Clinical Trials
  • Cortisone Injections
  • Dual Energy X-Ray Absorptiometry (DXA)
  • General Rheumatology
  • General Rheumatology Including Lupus
  • Hyaluronic Acid (HA)
  • Hyaluronic Acid Injections
  • Immunoglobulin Infusion
  • Immunology
  • Immunology of Infectious Diseases
  • Immunotherapy
  • Infusion Therapy
  • Infusions of Biologic Agents on Site
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation Center
  • Medical Management of Early Osteoarthritis
  • Medication Management
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Musculoskeletal Treatment for Joint Pain
  • Osteoporosis Diagnosis
  • Rheumatoid Arthritis: How to Treat
  • Rheumatology
  • Therapeutic Injections
  • Ultrasound-Guided Procedures
  • Viscosupplementation
View all 30 Treatment & Services +

Specialty in Diseases & Conditions

  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis of the Hip
  • Arthritis of the Knee
  • Arthritis of the Shoulder
  • Arthritis of the Thumb Base
  • Autoimmune Disease
  • Autoinflammatory Syndromes
  • Behcet's Disease
  • Benign Hypermobility Joint Syndrome
  • Buerger's Disease
  • Bursitis
  • Calcification Tendinitis
  • Calcinosis
  • Central Nervous System Vasculitis
  • Chondrocalcinosis (Pseudo Gout)
  • Churg-Strauss Syndrome
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryoglobulinemia
  • Dermatomyositis
  • Elbow Arthritis
  • Familial Mediterranean Fever (FMF)
  • General Infectious Diseases
  • Giant Cell Arteritis
  • Gout
  • Gout Arthritis
  • Granulomatosis with Polyangiitis (Wegener’s)
  • Hand Pain
  • Hand Problems
  • Henoch-Schonlein Purpura
  • Hepatitis B
  • Hepatitis C
  • Hip Disorders
  • Hip Pain
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Iritis
  • Joint Pain
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Lupus Anticoagulant
  • Lupus Nephritis
  • Metabolic Bone Disease
  • Metabolic Diseases
  • Microscopic Polyangiitis (MPA)
  • Musculoskeletal Disorders
  • Musculoskeletal Impairments
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis
  • Osteoarthritis of the Hips in the Elderly
  • Osteoarthritis of the Knees in the Elderly
  • Painful Joints
  • Palindromic Rheumatism
  • Panuveitis
  • Polyarteritis Nodosa
  • Polymyalgia Rheumatica
  • Polymyositis
  • Pseudogout
  • Psoriatic Arthritis
  • Radiculopathy
  • Raynaud's Phenomenon
  • Reactive Arthritis
  • Relapsing Polychondritis
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Rheumatoid Arthritis and Heart Disease
  • Sacroiliitis
  • Sarcoidosis
  • Scleritis
  • Scleroderma
  • Shoulder Pain
  • Sjogren's Syndrome
  • Spondylitis
  • Spondyloarthropathy
  • Spondylosis
  • Steroid-Induced Osteoporosis
  • Systemic Autoimmune Diseases
  • Systemic Lupus
  • Systemic Lupus Erythematosus
  • Tendinosis
  • Tendonitis
  • Tenosynovitis
  • Trigger Finger
  • Vasculitis
View all 90 Specialties +
Insurance

Insurance

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Biography

About Leonard Calabrese, DO

Leonard H. Calabrese, DO, heads Cleveland Clinic's Section of Clinical Immunology and manages its Clinical Immunology Clinic. He specializes in diseases of the immune system -- in particular, immunodeficiency diseases, such as human immunodeficiency virus (HIV) and other chronic viral infections, which are the subject of both clinical care and investigation. Dr. Calabrese is also Co-director of the Center for Vasculitis Care and Research and has a particular interest in vascular inflammatory disease of the central nervous system.

A graduate of the Kansas City University of Medicine and Biosciences , Dr. Calabrese performed his internal medicine training at Cleveland Clinic in Ohio, followed by a fellowship in rheumatic and immunologic disease. He has been a staff member in Cleveland Clinic's Department of Rheumatic and Immunologic Diseases since 1980.

Recipient of numerous awards and honors, Dr. Calabrese has received an honorary Doctorate of Humane Letters from the Kansas City University of Medicine and Biosciences, the Phillips Medal of Public Service from the Ohio University College of Osteopathic Medicine, the Bruce Hubbard Stewart Award for humanitarianism and Leonard Tow Humanitarianism in Medicine award from the Arnold P Goldman MD Foundation. He holds the R.J. Fasenmeyer Chair of Clinical Immunology and is the director of the RJ Fasenmyer Center for Clinical Immunology. When he was awarded the Theodore F. Classen, DO Chair in Osteopathic Research and Education in 2008 he became the first dual-chair holder in Cleveland Clinic history.

Dr. Calabrese is a member of many professional societies, including the American Association of Immunology, Clinical Immunology Society and the International AIDS Society and the American Osler Society. He is a fellow of the American College of Rheumatology, American College of Physicians and the American College of Sports Medicine.

Dr. Calabrese has lectured nationally and internationally on the subjects of HIV, immunology and rheumatology and is the author of more than 300 published peer-reviewed articles, book chapters and reviews.

Education & Professional Highlights

Education & Professional Highlights

Appointed
1980

Education & Fellowships

Fellowship - Cleveland Clinic
Immunologic Disease
Cleveland, OH USA
1980

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA
1978

Internship - Cleveland Clinic
Internal Medicine
Cleveland, OH USA
1976

Medical Education - Kansas City University of Medicine and Biosciences University of Health Sciences
Kansas City, MO USA
1975

Undergraduate - John Carroll University
University Heights, OH USA
1971

Professional Highlights

  • R.J. Fasenmeyer Chair of Clinical Immunology
  • Theodore F. Classen, DO Chair in Osteopathic Research and Education

Certifications

  • Internal Medicine
  • Internal Medicine - Rheumatology

Specialty Interests

Vasculitis, HIV/AIDS, Rhematic aspects of viral infections Vasculitis, HIV/AIDS, Hepatitis C

Awards & Honors

  • Honorary Doctorate of Humane Letters, Kansas City University of Medicine and Biosciences
  • Bruce Hubbard Stewart Award for humanitarianism
  • Phillips Medal of Public Service, Ohio University

Memberships

  • American College of Physicians
  • American College of Rheumatology
  • American Osler Society
  • Clinical Immunology Society
Research & Publications

Research & Publications

See publications for Leonard Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 8/24/2023, Dr. Calabrese has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Calabrese receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Johnson & Johnson
  • Sanofi Pasteur Inc.
  • AstraZeneca
  • GlaxoSmithKline plc.
  • AbbVie, Inc.
  • Galvani Bioelectronics Limited
  • Amgen, Inc.
  • UCB, SA

Donation of Financial Interest. Dr. Calabrese has consulted for, received compensation for serving as a fiduciary from, or received royalties from the following companies but instructed them to donate all compensation to not-for-profit causes or to the Cleveland Clinic to support research and education:

  • Bristol-Myers Squibb

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

44 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
5 out of 5
Explains 4.9
Courtesy, Respect & Concern 5
Patient Rating of Doctor 5

11 Patient Comments

Reviewed on Jun 15, 2023

Probably the best doctors appointment I have ever had

Reviewed on May 23, 2023

During the time I've been a patient at CC, Dr Calabrese is the only person that has ever expressed an Interest In and appreciation for me as a human being beyond being a sick person and a subset of symptoms.

Reviewed on May 23, 2023

Dr. Calabrese->exceptional clinician w/excellent diagnostic skill and clear compassionate communication skill

Reviewed on May 9, 2023

Betsy Kirchner is an outstanding caregiver! Professional, thoughtful, knowledgeable and kind, Betsy is a huge asset to this practice. Were I to leave Cleveland I would fly back just to continue my care with her and Dr. Calabrese!

Reviewed on May 9, 2023

Dr Calabrese contacted me after I was originally scheduled with a PA. My diagnosis required a higher level of care. He and Betsy are aware of all patients scheduled in their department and make sure they are provided with appropriate level of care.

Reviewed on May 9, 2023

Dr Calabrese listened to every symptom concern with empathy and understanding of my 12 year journey. He clearly explained plan of care moving forward and the reasons for the decisions. He also did a thorough physical exam. Majority of doctors today will never have a patient put on a gown and do a complete review of systems. We talked about how the mind,body and spiritual connection provides a sense of well being with chronic lifelong complex health issues.I was provided additional educational resources to attend from home. Most importantly, at the end of appointment he asked again if we covered everything I came to see him for. Amazing. He is making a global impact in the fields of rheumatology, immunology and chronic pain.

Reviewed on Apr 25, 2023

Doc was great as he always is.

Reviewed on Feb 14, 2023

Dr. Calabrese goes above and beyond for his patients. He really cares

Reviewed on Feb 7, 2023

I have been seeing Dr. Calabrese for years, and he is the best doctor who has tried to come up with a solution for my condition. I can't ask for a better doctor.

Reviewed on Nov 22, 2022

Dr.Calabreze and Rn Betsy, are the best.

Reviewed on Nov 15, 2022

Dr Len spent an hour with me evaluating my symptoms. The Best!

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