Overview

Overview

The Cleveland Alzheimer’s Disease Research Center (CADRC) is a collaborative effort of physicians and investigators from Case Western Reserve University (CWRU), the Cleveland Clinic Foundation (CCF), Cleveland Ohio and Las Vegas, Nevada sites, the Metro Health System (MHS), University Hospitals (UH), and the Louis Stokes Cleveland VA Medical Center (LSVA), to establish a National Institute on Aging (NIA) funded Alzheimer’s disease research center. The purpose of the CADRC is to improve our understanding of why Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRD) vary from person to person. The CADRC advances research into AD/ADRD to improve the lives of those affected by these devastating disease.

The CADRC is made-up of eight “Cores”. Potential participants are recruited through the Outreach, Recruitment, and Engagement Core managed by Dr. Martha Sajatovic. Participants undergo study procedures conducted by the Clinical Core under the supervision of Dr. Alan Lerner. Dr. Lynn Bekris is responsible for the processing and retention of biospecimens through the Biomarker Core. Data is securely stored and analyzed by the Data Management and Statistical Core led by Dr. Jonathan Haines. Dr. Mark Cohen and Dr. Brian Appleby facilitate brain donation and autopsy procedures through the Neuropathology Core. Under the guidance of Dr. Andrew Pieper, the Translational Therapeutics Core will use information gathered from the CADRC to study new therapies for dementia. Dr. Xiongwei Zhu, leader of the Research Education Component, will develop a professional education program in collaboration with the CADRC to train novice investigators in the field of dementia research. Dr. James Leverenz, the CADRC Principal Investigator, will lead the Administrative Core which holds the responsibility of building and maintaining the structure of the CADRC.

Contact Information:

James Leverenz, MD
leverej@ccf.org

Funding Sources:

NIH 1P30AG062428-01, Cleveland Alzheimer’s Disease Research Center, Leverenz (PI) 07/01/2019-06/30/2021

Members and Collaborations

Members and Collaborations

Cleveland Clinic Affiliations

External Relationships and Collaborations

  • Alan Lerner, MD
  • Brian Appleby, MD
  • Paula Ogrocki, PhD
  • Karin Mente, MD
  • Sherry Ball, PhD
  • Jonathan Haines, PhD
  • Mark Cohen, MD
  • Martha Sajatovic, MD
  • Xiongwei Zhu, PhD
  • Ignazio Cali, PhD
  • Wenzhang Wang, PhD
  • Andrew Pieper, MD, PhD