Dietmar Cordes, PhD, is the Director of the Neuroimaging Group at the Lou Ruvo Center for Brain Health in Las Vegas and the Stacie and Chuck Mathewson endowed chair for brain imaging. His primary research interest is the development of multivariate methods for functional, resting-state, and structural MRI. His group designs advanced tools to obtain a more accurate picture of the working brain to better characterize neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, and cognitive impairment in professional fighters.

The imaging group also develops imaging biomarkers that are dedicated specifically to the early detection of neurological diseases and monitoring effects of potential treatments. Ultimately, the imaging methods that are being developed will assist clinicians in improving the treatment and assessment of their patients.



A Family of Locally Constrained CCA Models for Detecting Activation Patterns in fMRI. Zhuang*, X., Yang*, Z., Curran, T., Byrd, R., Nandy, R., Cordes, D. (2017). NeuroImage, 149:63-84. http://dx.doi.org/10.1016/j.neuroimage.2016.12.081. PMID: 28041980.

A new algebraic method for quantitative proton density mapping using multi-channel coil information. Cordes, D., Yang, Z., Zhuang, X., Sreenivasan, K, Mishra V, Hua, LH. (2017) Medical Image Analysis, 40:154-171. PMID: 28668358.

Olfactory Network Differences in Master Sommeliers: Connectivity Analysis using Granger Causality and Graph Theoretical Approach. Sreenivasan, K., Zhuang, X., Banks, S., Mishra, V., Yang, Z., Gopikrishna, D., Cordes, D. (2017). Brain Connectivity 7:123-136. PMID: 28125912.

Multimodal MRI Signatures of Cognitive Impairment in Active Professional Fighters. Radiology. Mishra, V., Zhuang, X., Sreenivasan, K., Banks, S., Yang, Z., Bernick, C., Cordes, D. (2017). 2017 Jul 25:162403. doi: 10.1148/radiol.2017162403. PMID: 28741982.

Drug Development in Alzheimer’s Disease-The Role of Default Mode Network Assessment in Phase II. Cummings, J., Zhong, K., Cordes, D. (2017). US Neurology, 13(2): 67-69. DOI: https://doi.org/10.17925/USN.2017.13.02.67.

3D spatially-adaptive canonical correlation analysis: Local and global methods. Yang, Z., Zhuang, X., Sreenivasan, K., Mishra V., Curran, T., Byrd, R., Nandy, R., Cordes, D. (2018). NeuroImage, 14;169:240-255. PMID: 29248697.

Investigating structural and perfusion deficits due to repetitive head trauma in active professional fighters. Mishra, V., Zhuang, X., Sreenivasan, K., Banks, S., Yang, Z., Cordes, D., Bernick, C. (2018). NeuroImage Clinical, 17:616-627. PMID: 29234598.

Incorporating Spatial Constraint in Co-activation Pattern Analysis to Explore the Dynamics of Resting-State Networks: An Application to Parkinson’s disease. Zhuang, X., Walsh R., Sreenivasan, K., Yang Z., Mishra, V., Cordes, D. (2018). NeuroImage, 172:64-84. PMID: 29355770.

Advances in fMRI Data Analysis Methods using Empirical Mode Decomposition to Investigate Temporal Changes in Early Parkinson’s Disease. Cordes, D., Zhuang, X., Kaleem, M., Sreenivasan, K., Yang, Z., Mishra, V., Banks, S., Bluett, B., Cummings, J. (2018). Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 4:372-386. PMID: 30175232.

Neuroimaging and neuropsychological assessment of freezing of gait in Parkinson’s disease. Bluett, B., Banks, S., Cordes, D., Bayram, E., Mishra, V., Cummings, J., Litvan, I. (2018). Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 4:387-394. PMID: 30211293.

Default Mode Network Lateralization and Memory in Healthy Aging and Alzheimer’s Disease. Banks, S., Zhuang, X., Bayram, E., Bird, C., Cordes, D., Caldwell, J., Cummings, J. (2018). Journal of Alzheimer’s disease, J Alzheimers Dis. 2018;66(3):1223-1234. PMID: 30412488.

Neural Correlates of Distinct Cognitive Phenotypes in Early Parkinson’s Disease. Bayram, E., Bluett, B., Zhuang, X., Cordes, D, LaBelle, D.R., Banks, S.J. (2019). Journal of the Neurological Sciences, 399:22-29. PMID: 30743154.

Altered functional connectivity and network topology correlate with symptom severity and disease duration in very early-stage, drug-naïve Parkinson's Disease. Sreenivasan, K., Mishra, V., Bird, C., Zhuang, X., Yang, Z., Cordes, D., Walsh, R.R. (2019). Parkinsonism and Related Disorders, https://doi.org/10.1016/j.parkreldis.2019.02.001. PMID: 30772280.

Robust motion regression of resting-state data using a convolutional neural network model. Yang, Z., Zhuang, X., Sreenivasan, K., Mishra, V., Cordes, D. (2019). Frontiers in Neuroscience, https://doi.org/10.3389/fnins.2019.00169. PMID: 31057348.

Multivariate Second Level Analysis in fMRI with Canonical Correlation Analysis. Zhuang, X., Yang, Z., Curran, T., Nandy, R., Cordes, D. (2019). NeuroImage, 194:25-41. PMID: 30894332.

Influence of Analytic Technique on Comparing Diffusion-Derived Measurements in Early Stage Parkinson’s Disease. Mishra, V., Zhuang, X., Sreenivasan, K., Yang, Z., C., Cordes, D., Walsh. R.R. (2019). Heliyon, 5(4): e01481. doi: 10.1016/j.heliyon.2019.e0148. PMID: 31008407.

Performing Sparse Regularization and Dimension Reduction Simultaneously in Multimodal Data Fusion. Yang, Z., Zhuang, X., Bird, C., Sreenivasan, K., Mishra, V., Banks, S., Cordes, D. (2019). Frontiers in Neuroscience, https://doi.org/10.3389/fnins.2019.00642. PMID: 31333396.

Understanding white matter structural connectivity differences between cognitively impaired and nonimpaired active professional fighters. Mishra, V., Sreenivasan, Zhuang X., Yang, Z., Cordes, D., Banks S.J., Bernick, C. (2019). Hum Brain Mapp. 2019 Aug 12. doi: 10.1002/hbm.24761. PMID: 31403734.

Sex moderates amyloid and apolipoprotein E4 effects on default mode network connectivity at rest. Caldwell, J.Z.K., Zhuang, X., Leavitt, M.K., Banks, S.J., Cummings, J.L., Cordes, D. 2019. Frontiers in Neuroscience, Front Neurol. 2019 Aug 20;10:900. doi: 10.3389/fneur.2019.00900. PMID: 31481928.

Unique white matter structural connectivity in early stage, drug naïve Parkinson’s disease. Mishra VR, Sreenivasan KR, Yang Z, Zhuang X, Cordes D, Mari Z, Litvan I, Fernandez H, Eidelberg D, Ritter A, Cummings JL, Walsh RR. Neurology. 2019 July 30; In-Press.

Empirical Mode Decomposition and Energy-Period Characteristics of Brain Networks in Group fMRI Resting-State Data. Cordes, D., Kaleem, M., Yang, Z., Zhuang, X., Curran, T., Sreenivasan, K, Mishra, V., Nandy, R. (2019). Human Brain Mapping, under review.

DNNdenoise: An automated and robust deep neural network for denoising task-based fMRI data. Yang, Z., Zhuang, X., Sreenivasan, K., Mishra, V., Curran, T., Cordes, D. (2019). Medical Image Analysis, provisionally accepted pending revision.

Sensitivity of Classifying Cognitively Impaired and Nonimpaired Active Professional Fighters Using Topological Brain Disruptions in Large- Scale Cortical Networks. In revision. Mishra V, Zhuang X, Sreenivasan K, Yang Z, Banks S, Cordes D, and Bernick C.

Members & Collaborations

Members & Collaborations

Cleveland Clinic Affiliations

  • Dietmar Cordes, PhD
  • Virendra Mishra, PhD
  • Karthik Sreenivasan, MS - Imaging Scientist
  • Zhengshi Yang, MS - Imaging Scientist
  • Xiaowei Zhuang, MS - Imaging Scientist