Unlike 50 years ago, the chances of surviving a childhood cancer today are better than ever. While most survivors enjoy good health after their cure, some develop "late effects," which are chronic medical conditions or emotional difficulties that appear years after treatment.

The High-Five Cancer Survivor’s Clinic at Cleveland Clinic Children's is a long-term follow-up clinic for children and adults who have reached the point of five years from a diagnosis of pediatric cancer and who have been off therapy for at least three years.

Working together, hand in hand, our specially trained physicians, nurses and providers care for our childhood cancer survivor patients.  We work with an interdisciplinary team across specialties to provide individualized care tailored specifically for our survivors. In addition, we work with our patients' primary care physicians to make them aware of issues that may need close monitoring.

Who We Treat

Who We Treat

The High-Five Cancer Survivor’s Clinic team also counsels childhood cancer patients who are in the process of undergoing cancer therapy, as well as their families, to educate them about late effects and the importance of post-therapy follow-up care. In addition, we also work with those who have been treated for non-cancer diseases with chemotherapy, radiation therapy or stem cell transplant.

We help ensure survivor success by identifying and managing late effects in survivors. The professionals within the clinic help patients move forward confidently with their lives, armed with the information they need to preserve their health.

What We Look For

What We Look For

Late effects can be a result of surgery, chemotherapy, radiation and blood and marrow or stem cell transplants. The effects vary depending upon the type of cancer or noncancerous disease, the course of treatment and quite possibly the age of the child during treatment, among other things. Some examples of late effects are:

  • Secondary cancers
  • Infertility
  • Early menopause
  • Osteoporosis
  • Heart damage, including premature coronary artery disease
  • Neuropsychological effects, such as learning disabilities
  • Psychosocial issues like decreased self-esteem and stress
  • Pulmonary toxicity
  • Hormonal and growth disorders
  • Genitourinary problems
  • Gastrointestinal effects


The High-Five Cancer Survivor’s Clinic professionals can help with all these issues. By working together, hand in hand, we are able to meet the unique needs of our childhood cancer survivor patients and their families.

  • Seth Rotz, MD, Medical Director
  • Jennifer Weaver, RN
  • Taylor Buss, MSW, LSW
  • Erin Feldman, MSSA, LSW

Subspecialist Partners


High Risk Breast Center




Additional Partners


Genetic Counseling

  • Rebekah Moore MS, CGC, LGC


  • Gwen Barron, RD, LD
  • Sara Bewley, MS, RD, CSP, LD

We can also help provide the following resources:

  • Occupational or physical therapy
  • Vocational Rehab
  • Education Resources
    • IEP
    • 504 Plan


Open Trials

ALTE11C1. Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas.

ALTE1631. Web-based Exercise Study for Children and Adolescents with Acute Lymphoblastic Leukemia

ALTE07C1. Neuropsychological and Behavioral Testing in Younger Patients With Cancer.

ALTE16C1. Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma.

Previous Publications

Long-term systolic function in children and young adults after hematopoietic stem cell transplant. Rotz SJ, Dandoy CE, Taylor MD, Jodele S, Jefferies JL, Lane A, El-Bietar JA, Powell AW, Davies SM, Ryan TD. Bone Marrow Transplant. 2017 Jul 17. doi: 10.1038/bmt.2017.162. [Epub ahead of print] PMID:28714947

Cardiotoxicity and cardiomyopathy in children and young adult survivors of hematopoietic stem cell transplant. Rotz SJ, Ryan TD, Hlavaty J, George SA, El-Bietar J, Dandoy CE. Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26600. Epub 2017 Apr 28. Review. PMID:28453909

The injured heart: early cardiac effects of hematopoietic stem cell transplantation in children and young adults. Rotz SJ, Ryan TD, Jodele S, Jefferies JL, Lane A, Pate A, Hirsch R, Hlavaty J, Levesque AE, Taylor MD, Cash M, Myers KC, El-Bietar JA, Davies SM, Dandoy CE. Bone Marrow Transplant. 2017 Aug;52(8):1171-1179. doi: 10.1038/bmt.2017.62. Epub 2017 Apr 10

Pulmonary hypertension associated with bronchiolitis obliterans after hematopoietic stem cell transplantation. Pate A, Rotz S, Warren M, Hirsch R, Cash M, Myers KC, El-Bietar J, Nelson A, Wallace G, Filipovich AH, Bleesing J, Chima RS, Davies SM, Jodele S, Dandoy CE. Bone Marrow Transplant. 2016 Feb;51(2):310-2. doi: 10.1038/bmt.2015.248. Epub 2015 Oct 19. No abstract available. PMID:26479977

Cerebral vascular abnormalities in pediatric patients with sickle cell disease after hematopoietic cell transplant. Bodas P, Rotz S. J Pediatr Hematol Oncol. 2014 Apr;36(3):190-3. doi: 10.1097/MPH.0000000000000089. Review. PMID:24327127

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If you or your child is a survivor of childhood cancer, treated anywhere, and would like to make an appointment, call 216.444.1216.