Statins

Overview

What are statins?

Statins (HMG CoA reductase inhibitors) are prescription medicines that people take to bring their cholesterol down to normal levels. Some statins can decrease your LDL (bad) cholesterol by 50% or more. Different brands of statins are on the market, as well as generic statins, which cost less.

Statins are tablets or capsules that you swallow whole once a day. The label on your medicine bottle will tell you if you need to take your statin at a certain time of day and if you need to take it with food.

Types of statin drugs

• Atorvastatin.
• Fluvastatin.
• Lovastatin (Mevacor® or Altoprev™).
• Pitavastatin (Livalo® or Zypitamag®).
• Pravastatin.
• Rosuvastatin (Crestor® or Ezallor Sprinkle®).
• Simvastatin (Flolipid® or Zocor®).

Sometimes, statins are put together with another medicine in one pill, such as:

• Simvastatin with ezetimibe or niacin.
• Atorvastatin with ezetimibe or amlodipine.
• Lovastatin with niacin.

What do statins do?

Statins decrease your LDL (low-density lipoprotein) or bad cholesterol and may increase your HDL (high-density lipoprotein) or good cholesterol. LDL is bad because it builds up inside your arteries. HDL is good because it brings cholesterol to your liver, which gets it out of your body.

How do statins work?

Statins get in the way when your liver is trying to make cholesterol. Like a good basketball player who doesn’t let an opponent get the ball, statins don’t let your liver have an enzyme it needs to create cholesterol. Your body makes 75% of your cholesterol, so helping it make less can make a big difference. The rest of your body’s cholesterol is from what you’re eating.

Statins also help your liver get rid of more cholesterol.

Why do I have high cholesterol if I eat healthy foods?

You can get genes from your parents that tell your body to make more cholesterol than you need or not to absorb the cholesterol it needs.

Who needs to take statins?

Your healthcare provider will look at your individual situation when deciding if you should take a statin. Having diabetes, high blood pressure or high cholesterol and using tobacco products are all risk factors for getting heart disease. Your provider will also consider your age, sex and race when deciding if you need a statin.

Providers prescribe statins for people who:

• Have high cholesterol (LDL above 190 mg/dL) that exercise and diet changes couldn’t reduce.
• Had a stroke, heart attack or peripheral artery disease.
• Have diabetes and an LDL of at least 70 mg/dL and are 40 to 75 years old.
• Have an LDL of at least 70 mg/dL and a high risk of getting heart disease and are 40 to 75 years old.

Why are statins used?

Statins bring down your cholesterol level to make you less likely to have a heart attack or stroke. Your body uses cholesterol when it makes vitamin D, hormones and the acid you use to digest food. But if you have too much cholesterol in your blood, it can collect inside your arteries. This creates obstacles that make it harder for your blood to get through your blood vessels.

If cholesterol keeps building up in your arteries, it can do more than just make them narrow. The plaque (obstacles) in your blood vessels can become unstable and break open, leading to a heart attack.

How common are statins?

Statins are the most common drug class of prescriptions in America. More than 40 million adults take them.