Superior vena cava syndrome is when something presses on or blocks a big vein in your chest, disrupting blood flow. Lung cancer and certain implanted medical devices are the most common causes. Early signs include swelling and bulging veins in your upper body. Providers treat this condition with procedures, medications and (rarely) surgery.
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Superior vena cava syndrome — also known as SVC syndrome or SVCS — is a group of symptoms that occur when blood can’t flow normally through a large vein in your chest. This vein, called your superior vena cava, delivers blood from your upper body to your heart. But certain things — like tumors or blood clots — can press on or block this vein.
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When this happens, blood backs up in your superior vena cava. Sometimes, blood can reroute through nearby veins — like cars that detour around a traffic jam. This detour allows some blood to reach your heart. But a sudden or severe blockage can greatly disrupt blood flow and cause life-threatening symptoms.
There are two types of superior vena cava syndrome. The difference is what causes your symptoms:
SVC syndrome signs and symptoms include:
These symptoms might get worse when you lie flat on your back.
Cancer is a major cause of superior vena cava syndrome. Specific types of cancer that can cause it include:
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Benign causes include:
Most benign cases of superior vena cava syndrome occur as complications from an implanted medical device. For example, wires or catheters can irritate your vein. This can lead to inflammation, scarring and blood clot formation. Devices that can cause SVCS include:
It’s important to know that most people with these devices never get SVC syndrome. But the risk can vary based on the device type and how long it’s in the vessel.
Healthcare providers diagnose SVC syndrome by doing a physical exam and running some tests. Imaging tests can show if blood is flowing normally through your superior vena cava or detouring around a blockage.
Tests you may need include:
Treatment depends on the cause of SVCS and the severity of your symptoms. Possible treatments for SVC syndrome include:
These treatments can help improve blood flow to your heart. You may need more than one treatment. Your provider will explain which treatments are best for you and the benefits and risks.
Call your provider if you have symptoms of SVC syndrome. They’ll make sure you get the care you need.
You’ll likely need follow-up appointments with your provider after treatment. Follow the schedule your provider gives you. These visits are important and allow your provider to check the health of your blood vessels.
Call 911 or your local emergency number if you have these symptoms of severe or possibly life-threatening superior vena cava syndrome:
These symptoms can occur if there’s swelling of your brain or airways, or your major organs aren’t getting enough blood. You need immediate medical care.
Prognosis (outlook) with superior vena cava syndrome varies widely, depending on its cause and severity. In some cases, treating the underlying problem can cure SVC syndrome. Rarely, SVC syndrome is fatal.
Your healthcare provider can give you the most accurate sense of what you can expect. The condition that caused your SVC syndrome may affect your life expectancy. People with benign SVC syndrome typically live longer than those with malignant forms.
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Superior vena cava syndrome can cause a lot of stress. Maybe you’re already living with a cancer diagnosis, and these new symptoms are making you worry about your prognosis. Or maybe a medical device that’s giving you lifesaving treatment is suddenly causing these issues.
Whatever your situation, your healthcare provider is prepared to take care of you. They’ll explain what’s causing your symptoms and offer treatments that can help. Ask them any questions that come to mind. Make sure you understand what treatment will involve and when you should return for follow-up visits.
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Last reviewed on 04/24/2025.
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