Nonalcoholic Steatohepatitis

Overview

What is nonalcoholic steatohepatitis (NASH)?

Steatohepatitis is an advanced stage of nonalcoholic fatty liver disease (NAFLD). If you have fatty liver disease, your body has begun storing excess fat in your liver. This doesn’t always cause problems for people. But when it does, it’s called steatohepatitis.

“Hepatitis” means inflammation of the liver, and “steato” means from fat. Chronic inflammation of the liver can damage your organ, causing scarring of the tissues. If scarring progresses, it can lead to cirrhosis and eventually, liver failure.

Liver disease is frequently associated with chronic alcohol use. But if you have nonalcoholic fatty liver disease (NAFLD), you have this condition in spite of low alcohol use. Researchers aren’t sure why this occurs, but high levels of fats in the blood are a common factor.

Nonalcoholic steatohepatitis (NASH) is the advanced stage of nonalcoholic fatty liver disease. It means that your condition is causing inflammation and damaging your liver — again, in spite of low alcohol use.

How common is this condition?

Nonalcoholic fatty liver disease is common. Researchers estimate that up to 25% of adults in the U.S. have NAFLD, but only 20% of those with NAFLD have NASH.

What are some risk factors for the development of NAFLD and NASH?

Healthcare providers don’t know why some people with NAFLD develop NASH and some don’t. They don’t entirely know why people get nonalcoholic fatty liver disease. Some people seem to get it for no apparent reason. There may be a genetic factor.

However, NAFLD and NASH are more common in people who have certain conditions associated with high blood lipid levels. Studies suggest that 30% to 60% of people with Type 2 diabetes have NAFLD. Up to 75% of people who are overweight and up to 90% of people with class III obesity have NAFLD.

Is nonalcoholic steatohepatitis life-threatening?

NASH in itself isn’t necessarily life-threatening, but the presence of NASH with other risk factors such as older age and diabetes may increase the risk of progression to end-stage liver disease, which is a terminal condition.

Liver disease progresses slowly. Not everyone with steatohepatitis will progress to cirrhosis, which is late-stage, severe liver disease. However, liver disease can progress without noticeable symptoms. It’s possible to have a severe condition before you become aware of it.

In addition to having an increased risk for liver-related illness, people with NASH also tend to have a higher risk of suffering from a heart attack or stroke due to the presence of other comorbidities (when there are two or more medical conditions present) such as diabetes, high blood pressure and coronary artery disease.

Is nonalcoholic steatohepatitis reversible?

If you have mild-to-moderate liver damage, you can still stop it from progressing and even reverse some of the damage with healthy lifestyle changes. As steatohepatitis progresses, however, and more liver tissue turns to scar tissue, the liver begins to lose blood supply. This causes irreversible cell death.

Symptoms and Causes

What causes nonalcoholic steatohepatitis?

It’s not alcohol, but what is it? Researchers suspect it has something to do with fat levels in your blood, although not every case seems to fit this profile. Still, there’s a definite pattern of related risk factors leading to NASH.

Common risk factors include:

Additional risk factors include:

What are the symptoms of nonalcoholic steatohepatitis?

In earlier stages, many people don’t have any symptoms.

The most common symptoms of moderate NASH are:

More advanced stages may begin to resemble the symptoms of cirrhosis. You may notice:

What are the possible complications of nonalcoholic steatohepatitis?

The primary risk of NASH is progressive fibrosis leading to cirrhosis of the liver. This occurs in 5% to 12% of people with NASH.

Cirrhosis is associated with an increased risk of liver cancer. Most people with liver cancer have cirrhosis. NAFLD and NASH are also both associated with an increased risk of cardiovascular disease and Type 2 diabetes. It works both ways: having these conditions makes you more likely to have nonalcoholic steatohepatitis, and vice versa.

Diagnosis and Tests

How is nonalcoholic steatohepatitis diagnosed?

Your healthcare provider will begin by examining you for signs of liver disease. They’ll ask you about your health conditions and lifestyle, including alcohol consumption. If they suspect NAFLD or NASH, they’ll proceed to test for it in a few different ways.

Blood tests

By taking a sample of your blood to the lab, healthcare providers can test it to help identify liver damage.

  • Liver function tests check for evidence of liver inflammation, such as elevated liver enzymes and other metrics.
  • Fibrosis assessment tests can help healthcare providers estimate the level of scarring, or fibrosis.
  • A lipid panel measures levels of fats in your blood.
  • Other tests can help rule out other possible causes of hepatitis.

Imaging tests

Your healthcare provider will want to look at your liver for signs of inflammation, swelling and scarring. They may use:

  • Abdominal ultrasound, a noninvasive test that produces images using sonography (sound waves).
  • CT scan, a more intensive but more accurate imaging test that produces 3D X-rays.

Liver stiffness tests

These are modified imaging tests that help measure the level of stiffness and fibrosis in your liver.

  • FibroScan® is a specialized kind of ultrasound machine that can measure liver scar tissue and fat.
  • Magnetic resonance elastography (MRE) combines ultrasound and MRI imaging to create a visual map of liver fibrosis.

Liver biopsy

To confirm nonalcoholic steatohepatitis, the gold standard test is the liver biopsy. A biopsy may not be necessary if other tests show evidence of NASH, but it can help determine the extent of your condition.

Your healthcare provider will collect a small sample of your liver tissue by inserting a needle through your abdomen into your liver. By analyzing the tissue, they’ll be able to tell how much fat and how much fibrosis your liver has.

Management and Treatment

How is nonalcoholic steatohepatitis treated?

Unfortunately, at this time, there aren’t any medications available that can reverse the disease process. The cornerstone of management of NASH is weight loss through diet and lifestyle modification.

Guidelines include:

  • Losing weight. Losing 3% to 5% of your body weight has been shown to reduce fat levels in your liver. Losing between 5% and 10% of your body weight will help reduce inflammation as well. Your healthcare provider can help you create a plan to lose weight at a healthy pace.
  • Controlling your blood sugar. If you have diabetes, it’s especially important to monitor your blood sugar and take medications as directed. But it’s important for everyone with NASH to avoid sugar spikes from high-glycemic foods, such as sweetened products and white starches.
  • Maintaining a healthy diet. A balanced, heart-healthy diet is low in saturated fats and rich in monosaturated fats, such as those found in plants and seafood. It also includes plenty of fresh produce and whole grains. The Mediterranean diet is a good example.
  • Regularly exercising. This will help you manage your weight as well as stress, which can affect liver health. Aim for 30 minutes of moderate exercise at least three times a week.

Home remedies include:

  • Coffee. Some studies also suggest that drinking coffee daily can help prevent liver fibrosis due to nonalcoholic steatohepatitis. You have to tolerate caffeine well, though — researchers say it takes more than two cups per day to work, and decaf doesn’t count.

Prevention

How can I reduce my risk of nonalcoholic steatohepatitis?

Control your blood lipid levels by maintaining a healthy weight, reducing cholesterol in your diet and controlling your blood sugar. Get a little exercise most days. Avoid carcinogens such as tobacco smoke.

Outlook / Prognosis

Is nonalcoholic steatohepatitis curable?

Lifestyle changes can absolutely reduce or eliminate the inflammation associated with steatohepatitis. Inflammation is what triggers fibrosis and progressive liver damage — it’s what separates those with nonalcoholic steatohepatitis from those who live without problems from nonalcoholic fatty liver disease. Existing scar tissue can’t be revived, but most people have plenty of liver left to save.

A note from Cleveland Clinic

If you’re not much of a drinker, it might never occur to you to worry about your liver. But if you have any of the common risk factors for nonalcoholic steatohepatitis, such as obesity, diabetes or metabolic syndrome, consider this one to watch. NASH can progress without symptoms for many years. While there isn’t medical treatment, practical lifestyle changes can put your health back into your own hands.

Last reviewed by a Cleveland Clinic medical professional on 05/03/2022.

References

  • American Liver Foundation. Nonalcoholic Steatohepatitis (NASH) Information Center. (https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/nonalcoholic-steatohepatitis-information-center/) Accessed 5/3/2022.
  • American Liver Foundation. The Progression of Liver Disease. (https://liverfoundation.org/for-patients/about-the-liver/the-progression-of-liver-disease/#fibrosis-scarring) Accessed 5/3/2022.
  • National Institute of Diabetes and Digestive and Kidney Diseases. Definition & Facts of NAFLD & NASH. (https://www.niddk.nih.gov/health-information/liver-disease/nafld-nash/definition-facts) Accessed 5/3/2022.
  • National Institutes of Health. Nonalcoholic steatohepatitis. (https://rarediseases.info.nih.gov/diseases/6430/nonalcoholic-steatohepatitis) Accessed 5/3/2022.

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