Asthma Center

Asthma Control in Patients Receiving Advanced Therapies for Severe Asthma With Eosinophilia

Approximately 10% of patients with asthma have severe asthma, defined by the need for high-dose inhaled steroids or oral steroids, either to maintain control or despite which asthma control is still not achieved. ¹ In this group, even with optimal therapy, patients experience ongoing symptoms and have higher healthcare utilization. Therapies for severe asthma have significantly advanced in recent years. The Asthma Center uses a personalized approach based on the type of asthma (often referred to as asthma phenotype or endotype). Individuals with or without allergies may have a form of asthma called eosinophilic asthma, which results in significant symptoms and often requires high doses of medications, including even oral steroids.

To monitor patients closely for therapeutic response to biologics, the Asthma Center providers enroll patients in a registry. The center has > 300 patients enrolled in the registry for various biologics.²⁻⁸

In 2022, a greater number of severe asthmatics were treated with mepolizumab in our practice. The use of mepolizumab was associated with improvement of asthma control and decrease in the use of oral steroids.


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Improvement in ACT Scores for Patients with Severe Eosinophilic Asthma Treated With Mepolizumab


ACT = Asthma Control Test

In the cohort of 136 patients with severe asthma who were treated with mepolizumab, the median ACT score significantly improved at follow-up (P=0.0002 from 0 to 3 months and P=0.0125 from 0 to 6 months).

Percent of Patients Requiring Chronic Oral Steroid Administration While Receiving Mepolizumab (N = 136)


Utilization of oral corticosteroids for treating severe asthma is a source of morbidity from side effects and additional health risks. Asthma Center analysis demonstrates that patients’ need for oral steroids significantly decreased with therapy (P < 0.001).

These outcomes data demonstrate that comprehensive evaluation and multidisciplinary management of patients presenting to the Asthma Center improve asthma control even in the most severe cases. Rigorous monitoring and adjustments of therapies are needed as patients improve or require alternative advanced therapies available.⁹⁻¹⁰


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