Ocular Oncology Surgery

Uveal Melanoma

The mean incidence of uveal melanoma in the United States is 5.1 per million, with most cases (97.8%) occurring in the white population. Increasingly, uveal melanoma patients are being treated by radiation.

Several outcome measures can be considered when assessing treatment benefits of plaque radiation therapy for uveal melanoma. These include tumor specific mortality, local tumor control, globe salvage rate, and vision preservation. The recurrence rates following brachytherapy with plaque radiation therapy range from 10% to 15% in published studies in the United States. Because the outcomes of interest are likely to occur after the first year following primary therapy, Cole Eye Institute recently conducted a comprehensive 10-year outcomes study,¹ which showed that recurrence was uncommon, with a 5-year estimated recurrence rate of 6.6%.

Uveal Melanoma Surgeries (N = 447)

2018 – 2022

During the past 5 years, an average of 90 uveal melanoma surgeries have been performed annually at Cleveland Clinic.

Medium-sized choroidal melanoma located in the nasal quadrant of the left eye, which was treated with Iodine-125 episcleral plaque brachytherapy.

Note tumor regression and mild chorioretinal atrophy along the margins of the tumor. Note absence of radiation retinopathy and optic neuropathy.

  1. Bellerive C, Aziz HA, Bena J, Wilkinson A, Suh JH, Plesec T, Singh AD. Local failure after episcleral brachytherapy for posterior uveal melanoma: patterns, risk factors, and management. Am J Ophthalmol. 2017 May;177:9-16.