Overview
The Huntington’s disease Center of Excellence (HD COE) research team has a dedicated focus on clinical care, research, and innovation. The uniqueness of our Center is that it was developed from the ground up as a multidisciplinary center for HD care and treatment. Therefore, integrated and seamless medical management, neuropsychiatric support, and PT/OT/speech interventions are at the heart of our approach. Our HD COE has dedicated movement disorder research coordinators, psychiatrists, neurosurgeons, neuropsychologists, and the support of basic scientists at the Cleveland Clinic Lerner Research Institute for faster project start-up and better overall compliance and communication during clinical trials.
We are a distinctive center in which the clinical and research operations are merged. All physicians participate in research and work together in developing ideas and proposals and recruiting for clinical trials. Our HD COE has participated in numerous clinical trials focusing on predicting the onset and progression of pre-manifest and manifest Huntington disease. As an example, we were one of the nationally-recognized centers that participated in functional MRI imaging for HD in the PREDICT clinical trial. We were also part of the large CREST-E multicenter trial that evaluated the safety, tolerability, and efficacy of creatine in HD. The aims of our Center are 1) the development of biomarkers for the progression of Huntington disease and to understand their relationship to disease progression; 2) the prediction of pre-manifest Huntington's disease by using clinical and imaging measures; and 3) merging information from neuroimaging data, serial clinical information, and genetic information to predict accurately the onset of disease and the efficacy of novel drug intervention on disease progression.
Cleveland Clinic has been a certified site for Huntington's disease study group (consortium of academic research institutions). We currently are enrolling patients for a study called ENROLL-HD, which is the world's largest observational study for Huntington's disease families.
Contact Information
Adam Margolius, MD
margola@ccf.org
