Depression is a common mental health condition that causes a persistent feeling of sadness and changes in how you think, sleep, eat and act. There are several different types. Depression is treatable — usually with talk therapy, medication or both. Seeking medical help as soon as you have symptoms is essential.


What is depression?

Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest in things and activities you once enjoyed. It can also cause difficulty with thinking, memory, eating and sleeping.

It’s normal to feel sad about or grieve over difficult life situations, such as losing your job or a divorce. But depression is different in that it persists practically every day for at least two weeks and involves other symptoms than sadness alone.

There are several types of depressive disorders. Clinical depression, or major depressive disorder, is often just called “depression.” It’s the most severe type of depression.

Without treatment, depression can get worse and last longer. In severe cases, it can lead to self-harm or death by suicide. The good news is that treatments can be very effective in improving symptoms.


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What are the types of depression?

The American Psychiatric Association’s Diagnostic Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) classifies depressive disorders as the following:

  • Clinical depression (major depressive disorder): A diagnosis of major depressive disorder means you’ve felt sad, low or worthless most days for at least two weeks while also having other symptoms such as sleep problems, loss of interest in activities or change in appetite. This is the most severe form of depression and one of the most common forms.
  • Persistent depressive disorder (PDD): Persistent depressive disorder is mild or moderate depression that lasts for at least two years. The symptoms are less severe than major depressive disorder. Healthcare providers used to call PDD dysthymia.
  • Disruptive mood dysregulation disorder (DMDD): DMDD causes chronic, intense irritability and frequent anger outbursts in children. Symptoms usually begin by the age of 10.
  • Premenstrual dysphoric disorder (PMDD): With PMDD, you have premenstrual syndrome (PMS) symptoms along with mood symptoms, such as extreme irritability, anxiety or depression. These symptoms improve within a few days after your period starts, but they can be severe enough to interfere with your life.
  • Depressive disorder due to another medical condition: Many medical conditions can create changes in your body that cause depression. Examples include hypothyroidism, heart disease, Parkinson’s disease and cancer. If you’re able to treat the underlying condition, the depression usually improves as well.

There are also specific forms of major depressive disorder, including:

  • Seasonal affective disorder (seasonal depression): This is a form of major depressive disorder that typically arises during the fall and winter and goes away during the spring and summer.
  • Prenatal depression and postpartum depression: Prenatal depression is depression that happens during pregnancy. Postpartum depression is depression that develops within four weeks of delivering a baby. The DSM refers to these as “major depressive disorder (MDD) with peripartum onset.”
  • Atypical depression: Symptoms of this condition, also known as major depressive disorder with atypical features, vary slightly from “typical” depression. The main difference is a temporary mood improvement in response to positive events (mood reactivity). Other key symptoms include increased appetite and rejection sensitivity.

People with bipolar disorder also experience episodes of depression in addition to manic or hypomanic episodes.

Who does depression affect?

Depression can affect anyone — including children and adults. Women and people assigned female at birth are more likely to have depression than men and people assigned male at birth.

Having certain risk factors makes it more likely that you may develop depression. For example, the following conditions are associated with higher rates of depression:


How common is depression?

Depression is common. Researchers estimate that nearly 7% of adults in the United States have depression every year. More than 16% of U.S. adults — around 1 in 6 people — will experience depression at some point in their lifetime.

However, researchers believe that these estimates are lower than reality, as many people don’t seek medical help for symptoms of depression and don’t receive a diagnosis.

Approximately 4.4% of children in the United States have depression.

Signs and Symptoms

Depression symptoms: deep sadness, low energy, loss of interest, appetite or sleep changes, and more.
Clinical depression is a chronic condition, but it usually occurs in episodes, which can last several weeks or months.

What are the symptoms of depression?

The symptoms of depression can vary slightly depending on the type and can range from mild to severe. In general, symptoms include:

  • Feeling very sad, hopeless or worried. Children and adolescents with depression may be irritable rather than sad.
  • Not enjoying things that used to bring joy.
  • Being easily irritated or frustrated.
  • Eating too much or too little, which may result in weight gain or weight loss.
  • Trouble sleeping (insomnia) or sleeping too much (hypersomnia).
  • Having low energy or fatigue.
  • Having a difficult time concentrating, making decisions or remembering things.
  • Experiencing physical issues like headache, stomachache or sexual dysfunction.
  • Having thoughts of self-harm or suicide.

If you or a loved one are thinking about suicide, dial 988 on your phone to reach the Suicide and Crisis Lifeline. Someone will be available to help you 24/7.



What causes depression?

Researchers don’t know the exact cause of depression. They think that several factors contribute to its development, including:

  • Brain chemistry: An imbalance of neurotransmitters, including serotonin and dopamine, contributes to the development of depression.
  • Genetics: If you have a first-degree relative (biological parent or sibling) with depression, you’re about three times as likely to develop the condition as the general population. However, you can have depression without a family history of it.
  • Stressful life events: Difficult experiences, such as the death of a loved one, trauma, divorce, isolation and lack of support, can trigger depression.
  • Medical conditions: Chronic pain and chronic conditions like diabetes can lead to depression.
  • Medication: Some medications can cause depression as a side effect. Substance use, including alcohol, can also cause depression or make it worse.

Diagnosis and Tests

How is depression diagnosed?

Healthcare providers diagnose depression based on a thorough understanding of your symptoms, medical history and mental health history. They may diagnose you with a specific type of depression, such as seasonal affective disorder or postpartum depression, based on the context of your symptoms.

To receive a diagnosis of depression, you must have five depression symptoms every day, nearly all day, for at least two weeks.

Your provider may order medical tests, such as blood tests, to see if any underlying medical conditions are causing your depressive symptoms.

Management and Treatment

How is depression treated?

Depression is one of the most treatable mental health conditions. Approximately 80% to 90% of people with depression who seek treatment eventually respond well to treatment.

Treatment options include:

  • Psychotherapy: Psychotherapy (talk therapy) involves talking with a mental health professional. Your therapist helps you identify and change unhealthy emotions, thoughts and behaviors. There are many types of psychotherapy — cognitive behavioral therapy (CBT) is the most common. Sometimes, brief therapy is all you need. Other people continue therapy for several months or years.
  • Medication: Prescription medicine called antidepressants can help change the brain chemistry that causes depression. There are several different types of antidepressants, and it may take time to figure out the one that’s best for you. Some antidepressants have side effects, which often improve with time. If they don’t, talk to your healthcare provider. A different medication may work better for you.
  • Complementary medicine: This involves treatments you may receive along with traditional Western medicine. People with mild depression or ongoing symptoms can improve their well-being with therapies such as acupuncture, massage, hypnosis and biofeedback.
  • Brain stimulation therapy: Brain stimulation therapy can help people who have severe depression or depression with psychosis. Types of brain stimulation therapy include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS) and vagus nerve stimulation (VNS).

There are also things you can do at home to help improve depression symptoms, including:

  • Getting regular exercise.
  • Getting quality sleep (not too little or too much).
  • Eating a healthy diet.
  • Avoiding alcohol, which is a depressant.
  • Spending time with people you care about.


Can I prevent depression?

You can’t always prevent depression, but you can help reduce your risk by:

  • Maintaining a healthy sleep routine.
  • Managing stress with healthy coping mechanisms.
  • Practicing regular self-care activities such as exercise, meditation and yoga.

If you’ve had depression before, you may be more likely to experience it again. If you have depression symptoms, get help as soon as possible.

Outlook / Prognosis

What is the prognosis of depression?

The prognosis (outlook) of depression varies depending on certain factors, including:

  • Its severity and type.
  • If it’s temporary or long-lasting.
  • If it’s treated or untreated.
  • If you have co-occurring conditions, such as other mood disorders, medical conditions or substance use disorder.

With proper diagnosis and treatment, the vast majority of people with depression live healthy, fulfilling lives. Depression can return after you get treatment, though, so it’s important to seek medical help as soon as symptoms begin again.

Without treatment, depression can:

  • Become worse.
  • Increase your chance of other health conditions, like dementia.
  • Lead to the worsening of existing health conditions, like diabetes or chronic pain.
  • Lead to self-harm or death.

Depression accounts for nearly 40,000 cases of suicide each year in the United States. It’s essential to get medical help as soon as possible if you’re having suicidal thoughts. Call 911 or 988 (the Suicide and Crisis Lifeline) or go to the emergency room.

Living With

When should I see my healthcare provider about depression?

If you have symptoms of depression, see a healthcare provider or mental health professional. They can give you an accurate diagnosis and suggest treatment options.

If you’ve started treatment for depression and it isn’t working or you’re having unpleasant side effects, talk to your provider. They can recommend a different treatment plan.

A note from Cleveland Clinic

Depression is a common condition that affects millions of people every year. Anyone can experience depression — even if there doesn’t seem to be a reason for it. The good news is that depression is treatable. If you have symptoms of depression, talk to your healthcare provider. The sooner you get help, the sooner you can feel better.

Medically Reviewed

Last reviewed on 01/13/2023.

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