Visceral Hypersensitivity

Overview

What is visceral hypersensitivity syndrome?

Visceral hypersensitivity refers to your experience of pain or discomfort in your visceral organs — the soft, internal organs that live in your chest, abdomen and pelvic cavity. If you have visceral hypersensitivity, your threshold for pain in these organs is lower than normal.

Healthcare providers have been able to measure the visceral pain threshold in certain patients with tests that apply small amounts of internal pressure to some of these organs. Most people don't experience discomfort from these tests, but those with visceral hypersensitivity do. They also may feel discomfort from the normal functioning of the organs that other people wouldn’t notice.

How does visceral sensitivity affect my body?

Your visceral organs include your heart and lungs, your bladder and reproductive organs and the organs in your digestive system. Visceral hypersensitivity (VH) can make the normal functioning of one or several of these organs feel uncomfortable. Many people with visceral hypersensitivity are also diagnosed with functional disorders, especially gastrointestinal ones.

Functional disorders cause pain and discomfort in the internal organs in response to normal amounts of internal pressure from gas, fluids or solids moving through. Healthcare providers believe that visceral sensitivity plays a role in how these functional disorders develop (their etiology).

Is visceral hypersensitivity the same as IBS?

No, but it's often involved in IBS, and people who have IBS are the ones most commonly evaluated for visceral hypersensitivity. About 40% of people with IBS are diagnosed with VH. Healthcare providers believe that visceral hypersensitivity may result from and/or contribute to chronic IBS symptoms. It's also involved in other functional disorders, but most of the research on visceral hypersensitivity is related to IBS.

How common is this condition?

Visceral hypersensitivity is a relatively new diagnosis. We don’t know yet exactly how common it is. We do know that functional disorders are common. IBS alone affects at least 20% of the population, and up to 40% of people with IBS have visceral hypersensitivity. Considering how many other functional disorders may involve visceral hypersensitivity, it’s easy to estimate that VH affects at least 10% of the population.

Who does visceral hypersensitivity affect?

Visceral hypersensitivity usually accompanies another functional disorder. However, not everyone with a functional disorder appears to have visceral hypersensitivity. It also has a significant overlap with stress-related mood disorders. And there is some evidence that it may run in families. VH is twice as common in people assigned female at birth as it is in those assigned male at birth.

You may be more likely to have visceral hypersensitivity if you have:

Symptoms and Causes

What does visceral hypersensitivity feel like?

In language, the word “visceral” implies a deep-down, intuitive feeling, as in “a visceral reaction." It's also closely associated with your gut, as in a “gut feeling." Visceral pain has these qualities.

It can be diffuse, or not as precisely located as somatic pain from an injury, even when it is intense. It commonly affects the gut, causing symptoms of abdominal pain, nausea and indigestion, even when the source of the pain is located elsewhere. It also may feel closely tied to your emotional or mental state. Pain in the visceral organs can both trigger and be triggered by mental/emotional distress.

What are visceral symptoms?

People with visceral hypersensitivity tend to feel chronic discomfort in their chest, tummy or lower organs. Chronic pain is defined as lasting consistently for more than three months. It may come and go, or it may be triggered by certain bodily functions, such as a full bladder or swallowing food. The organs affected may include your:

Visceral pain can be diffused or difficult to localize, and it can sometimes radiate somewhere else. This can make it tricky to pin down and diagnose. One telltale feature of visceral pain is that it may produce strong autonomic responses from your body, such as:

  • Pallor.
  • Sweating.
  • Whole-body motor responses.
  • Changes in body temperature.
  • Changes in blood pressure.
  • Changes in heart rate.

People with VH may also have other symptoms of functional gastrointestinal disorders. These disorders exhibit the same symptoms as inflammatory diseases, such as GERD, peptic ulcer disease and inflammatory bowel disease. The only difference is that with functional disorders, healthcare providers can’t detect any organic cause for them — no ulcers, no acid reflux, and no chronic inflammation.

Typical symptoms of functional GI disorders include:

Healthcare providers have also noted some less typical symptoms reported by people with IBS that may be related to visceral hypersensitivity. For example:

  • Pain response to a light touch on your abdomen.
  • Burning sensations referred to different parts of your body.
  • Hypersensitivity to cold.
  • Pain referred to your upper and lower extremities.

These symptoms suggest that, beyond simply physical irritants, the nervous system is involved.

What causes visceral hypersensitivity?

Researchers are still working to understand exactly how visceral hypersensitivity develops. They speculate that the neurological response to pain may become overly sensitized by either severe or repeated exposure to physical, mental and/or emotional stress. Researchers have found several factors that may combine to lead to this response to pain. Some of these factors include:

  • Genes. Certain people may be genetically predisposed to develop hypersensitive responses that are biased toward enhanced pain perception.
  • Early life trauma. Early childhood is a crucial period for the development of the brain circuitry that regulates stress and pain perception. Early life trauma is one factor that could change the way this circuitry develops, especially if there is already a genetic predisposition toward hypersensitivity. This could include mental/emotional trauma or a significant illness, infection or injury in childhood.
  • Psychological disorders. Some of the same mechanics that predispose toward pain disorders can also predispose toward psychological disorders such as anxiety and depression. By the same token, people with psychological disorders are more frequently activating their pain and stress circuitry, driving it toward sensitization.
  • Social stress factors. Adult life has many common stress factors, but with adequate social support and physical resilience, most people can weather them. Some adults are more vulnerable, however, because of the many factors listed above. Without adequate coping mechanisms, some develop chronic pain syndromes.
  • Leaky gut syndrome. Several organic causes, as well as chronic stress, may cause chronic low-grade inflammation in the gut. This can erode the protective lining in your GI tract. One theory is that this may allow inflammatory agents to permeate the gut barrier and activate the central nervous system.
  • Bad gut microbiome. The balance of bacteria that live in your gut can affect your visceral pain sensitivity. Gut bacteria communicate with the central nervous system about how your gut is doing. Though it’s unclear why, overgrowth of the wrong kind, or eradication of beneficial bacteria by antibiotics, is associated with visceral hypersensitivity.

When your nervous system has already been primed for a hyper-reactive pain response, visceral pain may begin either at the site of the organ or in the brain as a pathophysiologic response to stress. Healthcare providers have noted that visceral hypersensitivity often develops following a specific event. For example, an injury or infection or severe stress may have caused acute pain and inflammation in one of your organs. But after the emergency passed, your nerves continued to interpret normal sensations as pain and send those pain signals to your brain.

These nerves send pain signals to the part of your brain that registers pain, which signals to your brain regions that process the emotional part of the pain. An emotional response is part of your body’s way of teaching you to avoid whatever injured you. But this neural pathway also works in the reverse, where stress and emotions can enhance the perception of physical pain or irritation in the visceral organs. With visceral hypersensitivity, physical pain and emotional stress can constantly reinforce each other. Your brain responds to both with stress hormones, which make symptoms worse.

How does visceral sensitivity contribute to functional gastrointestinal disorders such as IBS?

Your digestive system has its own nervous system, the enteric nervous system, which extends throughout the gastrointestinal tract. This is sometimes referred to as your “second brain” or the “brain in your gut." The enteric nervous system has nerve endings in every layer of the digestive organs. These nerve endings are activated by all kinds of things: digestive contents, bacteria and bacterial byproducts, stretch and distension, inflammation and chemical stress signals.

These nerves communicate discomfort to your brain, but they also signal your body to respond to the perceived threat in various ways: slowing or accelerating the digestive processes, purging out infectious agents and so on. If these nerves become chronically overexcited, they may perpetually trigger these kinds of responses, leading to symptoms of illness. Alternatively, VH may simply cause you to interpret normal gastrointestinal function as painful.

Diagnosis and Tests

How is visceral hypersensitivity diagnosed?

Although a variety of tests are used to diagnose VH in clinical studies, they aren’t normally given to patients seeking medical care. Visceral hypersensitivity is more often diagnosed the way other functional disorders are: by observing your symptoms and ruling out any structural causes for them. You’ll give a complete medical history and receive a complete exam before any standard tests are ordered. If these come back negative, you may be diagnosed with VH.

Management and Treatment

What treatment is available for visceral hypersensitivity?

Researchers are still investigating new ways of targeting visceral hypersensitivity. Currently, treatment usually involves a combination of pharmaceutical and mind/body therapies. Since this condition equally involves your physical organs and your brain, approaching it from both sides is more pragmatic and has a better chance of long-term success.

Medications

Medications for VH are targeted to calm your nervous system. Typical pain medications don’t work for this type of pain. Heavy pain blockers like narcotics and opioids are not recommended because their side effects can make things worse. Instead, healthcare providers typically prescribe the same medications they would for psychological mood disorders such as anxiety and depression, only in much lower doses.

This isn't because they are presuming that you have mood disorders. Some people with VH do, but some don’t. If psychological symptoms are enhancing your pain threshold, these medications will help raise that threshold. But they also help numb the pain signals from the nerves themselves. Treating the pain itself can help reduce stress hormones and put your body and brain in a better place to benefit from mind/body therapies.

Antidepressants include:

  • Tricyclic antidepressants.
  • Selective serotonin reuptake inhibitors (SSRIs).
  • Selective noradrenaline and serotonin inhibitors (SNRI).

Other medications that may help with nerve pain include:

  • Histamine H1 receptor antagonists.
  • Anti-epileptic drugs.

Mind/body therapies

Medications can help treat your symptoms, but they don’t treat the underlying condition. That’s what mind/body therapies try to do. Taking advantage of neuroplasticity — the ability of your nervous system and brain to learn new patterns — these therapies attempt to stop nerve pain from initiating in the first place. Recommended therapies include:

  • Cognitive behavioral therapy. This is a long-term, systematic way of retraining your nervous system’s response to sensation from the “top down” — that is, from the level of the mind.
  • Hypnotherapy. The power of suggestion in a hypnotic state may help to calm nervous pain response.
  • Biofeedback. This therapy method uses equipment to measure your physical responses to pain and draw your attention to those responses. Then you can work on changing them.

Complimentary medicine

These recommendations have not been thoroughly tested but have shown promise for helping to treat visceral hypersensitivity.

  • Probiotics. Following the theory that an imbalanced gut microbiome may contribute to visceral hypersensitivity, probiotics and prebiotics may help symptoms.
  • Acupuncture. Acupuncture has been shown effective in treating chronic pain in some people.
  • Psychotherapy. If it’s indicated, psychotherapy for related anxiety and depression may help relieve mental/emotional stress and affect your pain perception.

Outlook / Prognosis

Can visceral hypersensitivity be cured?

We don’t know. There have been inspiring reports of certain therapies significantly improving the condition for certain people. But this likely depends on many factors, including the original cause of their symptoms and how many other contributing factors are affecting their hypersensitivity. The good news is that research is ongoing and many promising avenues are being explored for targeting visceral hypersensitivity.

Living With

Can diet help with my visceral hypersensitivity symptoms?

Diet is often recommended to help with IBS symptoms. If your visceral sensitivity occurs in your GI tract, diet may help by reducing the discomfort associated with poor digestion.

Digestion is not necessarily a component of visceral hypersensitivity. However, if you do have intolerances to certain foods, they could cause chronic low-grade inflammation, eroding your gut barrier, and over-feeding bad gut bacteria that feed on the carbohydrates that you can’t digest. All of these effects have been suggested as contributing causes of visceral hypersensitivity. In this case, the following diets might help:

  • Elimination diet. This is a temporary diet to identify food intolerances. It removes common trigger foods and then adds them gradually back in as you watch your symptoms.
  • Low FODMAP diet. This is a specific elimination diet that targets the carbohydrates that most commonly cause digestive distress. If you have bacterial overgrowth, the low FODMAP diet will help reduce it by starving them of the carbohydrates they depend on.
  • Probiotic foods. If a bad gut microbiome is contributing to your troubles, probiotics may help. One of the best ways to get your daily probiotics is through probiotic foods, such as yogurt and cottage cheese, sauerkraut and miso soup.

A note from Cleveland Clinic

Visceral hypersensitivity is a complex problem, and treating it requires a holistic approach. Healthcare providers increasingly recognize the importance of the gut-brain connection. Researchers are working to better understand the ways that our brains, organs and nervous systems communicate with each other, and how this might go wrong.

One thing’s for sure: Visceral pain isn’t “all in your head." But it is a little bit. That makes it trickier to target than a mechanical problem, but it also gives you some power. By activating the power of your brain, you can work to change your own neural pathways to reduce pain.

Last reviewed by a Cleveland Clinic medical professional on 05/11/2022.

References

  • Zhou Q, Verne GN. New insights into visceral hypersensitivity—clinical implications in IBS. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437337/) Nat Rev Gastroenterol Hepatol. 2011;8(6):349-355. Accessed 11/4/2021.
  • Farzaei MH, Bahramsoltani R, Abdollahi M, Rahimi R. The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056566/) J Neurogastroenterol Motil. 2016;22(4):558-574. Accessed 11/4/2021.
  • Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. (https://www.gastrojournal.org/article/0016-5085(94%2990086-8/pdf?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F) Gastroenterology. 1994;107(1):271-293. Accessed 11/4/2021.
  • Zhou Q, Verne GN. New insights into visceral hypersensitivity—clinical implications in IBS. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437337/) Nat Rev Gastroenterol Hepatol. 2011;8(6):349-355. Accessed 11/4/2021.
  • Pusceddu, M.M., Gareau, M.G. Visceral pain: gut microbiota, a new hope?. (https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0476-7#citeas) _J Biomed Sci._2018;25:73. Accessed 11/24/2021.
  • Greenwood-Van Meerveld B, Johnson A C. Stress-Induced Chronic Visceral Pain of Gastrointestinal Origin. (https://www.frontiersin.org/articles/10.3389/fnsys.2017.00086/full) _Frontiers in Systems Neuroscience. _2017;11:86. Accessed 11/4/2021.
  • Sikandar S, Dickenson AH. Visceral pain: the ins and outs, the ups and downs. Curr Opin Support Palliat Care. 2012;6(1):17-26. Accessed 11/4/2021.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy