Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder in which thrombi (blood clots) form in small blood vessels throughout your body. These blood clots can restrict the flow of oxygen-rich blood to your organs, causing several life-limiting complications. Treatments include plasma therapy, medication and surgery.
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Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder. With TTP, blood clots (thrombi) develop in small blood vessels throughout your body. These thrombi can restrict blood flow to your body’s vital organs, including your brain, kidneys and heart. As a result, serious medical problems can arise.
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The name of this condition provides clues about what’s involved:
TTP is a serious condition that comes on quickly and needs urgent medical care. It can come back after treatment, but when it’s active, the symptoms are usually clear. Sometimes it’s triggered by things like a viral infection, surgery or pregnancy. Without treatment, TTP can be life-threatening.
TTP usually comes on quickly, and while it can come back in some people, the symptoms don’t come and go. They tend to be steady and noticeable. It won’t improve on its own and always needs treatment.
TTP causes blood clots to form in small blood vessels throughout your body. These clots can affect any organ, but your brain is often the first place symptoms show up.
If clots form in your heart, they can cause dangerous heart rhythms or even death. TTP also leads to anemia and low platelet levels (called thrombocytopenia). Some people may have bleeding, but that’s less common.
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Common thrombotic thrombocytopenic purpura symptoms include:
The clots that cause problems with TTP form when you don’t have enough ADAMTS13 enzyme. This enzyme prevents platelets from forming blood clots when you don’t need them. When there’s a deficiency of ADAMTS13, clots form in small blood vessels throughout your body. Red blood cells can break apart when they collide with a clot.
Because so many platelets are used up to form unneeded clots, there aren’t many left over to help with clotting when you actually need it (like when you cut your skin). If your platelet count gets very low, you may bruise more easily or bleed more than usual.
TTP can be:
Experts aren’t sure about what triggers symptoms of thrombotic thrombocytopenic purpura. But some people experience symptom flares associated with:
Thrombotic thrombocytopenic purpura can be life-threatening without treatment. The blood clots can block blood flow, leading to complications like:
Your healthcare provider will perform a physical exam and ask about your symptoms and health history. If your provider suspects TTP, they might need to run tests like:
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In most cases, providers use plasma therapy to treat TTP. Other options include medication.
The most common treatments involve infusions:
Plasma therapy happens in a hospital. Your care team continues treatment until your symptoms improve. This may take days or weeks.
Certain medications can slow or stop anti-ADAMTS13 antibodies from forming. Medications healthcare providers use to treat TTP include:
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In rare cases, your provider may recommend surgical spleen removal (splenectomy). You might need this if you have severe TTP that doesn’t respond to treatment or keeps coming back.
Recovery depends on several factors, including the severity of your condition and the treatment that you receive. Most people who have plasma therapy for TTP will need several days up to a few weeks. Those who have a splenectomy usually need about four to six weeks to recover.
TTP symptoms are usually serious enough to require an emergency room visit. If TTP is suspected, don’t wait for a routine appointment — immediate treatment is critical. Managing acute TTP requires the expertise of hematologists and intensive care specialists.
TTP used to be fatal. But with fast treatment, the death rate is now around 10%. Because relapses can happen, it’s important to stay in close contact with your hematologist after treatment. Regular monitoring of your ADAMTS13 level helps catch changes early. If the level drops before symptoms return, preventive treatment with rituximab can help stop a relapse before it starts.
Without treatment, only 1 out of 10 people with TTP survives. But with proper care, the survival rate goes up to 8 or 9 out of 10 people.
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This is why it’s essential to seek treatment if you’re experiencing symptoms. And it’s important to follow your provider’s guidance about caring for yourself once you’re diagnosed.
With proper treatment, most people with thrombotic thrombocytopenic purpura (TTP) lead normal lives. Your provider will explain how often you’ll need tests to monitor your condition. They’ll let you know if you need regular treatments to reduce your risk of bleeding and clots.
In the meantime, seek treatment immediately if you’re experiencing symptoms of TTP. TTP is a medical emergency. But prompt care can save your life.
When you hear a rare diagnosis like bone marrow failure and cytopenias, you want the best possible care. At Cleveland Clinic we’re experts in these rare conditions.
Last reviewed on 05/05/2025.
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