Factor V Leiden thrombophilia is a genetic condition that makes your blood more likely to clot when it shouldn’t. You may develop clots in your legs (deep vein thrombosis) or your lungs (pulmonary embolism). Prompt treatment is lifesaving. Avoid tobacco use, excessive alcohol and estrogen-based therapies to lower your risk of these complications.
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Factor V Leiden thrombophilia is an inherited blood clotting disorder. This means you’re born with a gene change that makes your blood more likely to clot when it shouldn’t. You have a higher risk than those without this condition of developing:
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
Having this condition doesn’t automatically mean you’ll develop DVT or PE. In fact, the vast majority of people (9 out of 10) never develop abnormal blood clots. But the disorder raises your risk compared to people without the disorder.
The prevalence of factor V Leiden varies by ethnicity. In general, it’s more common among people who are white in the U.S. and Europe.
In the U.S., this disorder affects:
Around 1 in 5 people who develop a blood clot in their veins have the factor V Leiden variant.
This condition’s name is pronounced “FAK-ter five LYE-den.” The “V” stands for the number five in Roman numerals.
The gene change itself doesn’t cause any symptoms. It’s possible to have this disorder and never even know it. But you may develop symptoms if a blood clot forms.
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If you have symptoms of DVT or a PE, call 911 or your local emergency number. Or ask someone to drive you to the nearest emergency room.
Symptoms of deep vein thrombosis include:
Symptoms of a pulmonary embolism include:
A gene variant causes factor V Leiden. “Coagulation factor V” is the name of a protein that helps your blood clot when needed, like after an injury. Your F5 gene tells your body how to make this protein.
Most people are born with two normal copies of the F5 gene. But if you inherit an abnormal copy, you have the factor V Leiden variant (sometimes called a mutation). “Leiden” is the city in the Netherlands where researchers discovered this gene variant.
The factor V Leiden variant tells your body to make a protein that has one small change in its structure. This change makes the protein resist other proteins (protein C and protein S) that stop excessive clotting. Without this check, factor V can make your blood clot when it shouldn’t.
Yes. You inherit this condition from one or both of your biological parents. Factor V Leiden follows an autosomal dominant inheritance pattern. That means only one of your parents has to pass the gene variant on to you for you to inherit it.
Most people with factor V Leiden inherit just one abnormal gene copy (heterozygous). Rarely, you can inherit two abnormal gene copies — one from each parent (homozygous).
You’re more likely to develop a blood clot if you:
Talk to your healthcare provider about your risk for developing blood clots and what precautions you should take.
If you have factor V Leiden thrombophilia, you may experience:
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Blood tests (including genetic testing) can show if you have factor V Leiden thrombophilia. Your healthcare provider may suggest testing for the condition if:
It’s a lifelong condition. There’s no cure or treatment for the gene variant itself. Instead, treatment involves breaking up any blood clots that form and lowering your risk of future clots. Your provider may recommend:
How long you need to take blood thinners depends on your risk of blood clots coming back. Some people only need to take them for a few months. Others need them long term. Your provider will explain the best treatment plan for you.
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Visit your provider for a yearly checkup. If you’ve been diagnosed with DVT or a PE, you’ll have frequent follow-up appointments so your provider can check treatment progress. If you’re taking warfarin, you’ll need routine blood testing (prothrombin time test) to check how well your medication is working.
It’s also important to talk to your provider:
Factor V Leiden doesn’t affect life expectancy in most people. Even if you develop a blood clot, prompt treatment can prevent a fatal outcome. It’s important to talk to your provider about any concerns you have related to life expectancy or future complications.
Your healthcare provider will tailor advice to your needs. In general, you should avoid:
These are two different genetic conditions. Both conditions involve changes to the F5 gene. With factor V Leiden, the change makes your blood clot too easily. But with factor V deficiency, the change stops your blood from clotting when it should.
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Factor V deficiency is a rare bleeding disorder that affects about 1 in 1,000,000 people. It can involve recurrent nosebleeds, heavy menstrual bleeding and prolonged bleeding after surgery.
If you or a loved one has factor V Leiden thrombophilia, you might worry about what the future will bring. It may ease your mind to know that most people with this disorder never have a blood clot. But if you do develop clots, there are treatments that can help. Following your provider’s guidance can help you find and manage problems early before they interrupt the flow of your life.
Blood clotting disorders can be genetic (inherited) or acquired. Cleveland Clinic’s experts diagnose and treat these disorders to lower your risk of complications.
Last reviewed on 05/07/2025.
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