Lung Volume Reduction Program

Improvement in Lung Function and Exertional Capacity

Patients who underwent LVR surgery at Cleveland Clinic between 2004 and 2022 showed improvement in lung function, as measured by forced exhaled volume in 1 second, and exertional capacity, as measured by 6-minute walk test distance.

Improvement in Lung Function

2004 – 2022

FEV₁ = forced exhaled volume in 1 second

Improvement in Exertional Capacity

2004 – 2022

Probability of Survival After LVR Surgery

2004 – 2022

When compared with the NETT cohort,¹ the Cleveland Clinic cohort achieved similar probability of survival at 1, 3, and 5 years postoperatively.

LVR = lung volume reduction

ᵃNETT cohort data for upper lobe predominant, low exercise capacity patients


  1. Naunheim KS, Wood DE, Mohsenifar Z, Sternberg AL, Criner GJ, DeCamp MM, Deschamps CC, Martinez FJ, Sciurba FC, Tonascia J, Fishman AP; National Emphysema Treatment Trial Research Group. Long-term follow-up of patients receiving lung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group. Ann Thorac Surg. 2006 Aug; 82(2):431-443.