Head & Neck Institute Outcomes
Head and Neck Surgery and Oncology
Identifying an Oligometastatic Phenotype in HPV-Associated Oropharyngeal Squamous Cell Carcinoma: Implications for Clinical Trial Design
2001-2018
Patients with human papillomavirus (HPV) associated squamous cell carcinoma of the oropharynx (SCC-OP) have improved overall survival after distant metastasis compared to HPV negative patients. These patients may be appropriate candidates for enrollment on clinical trials evaluating the efficacy of metastasis-directed therapy. This study seeks to identify prognostic factors associated with overall survival after distant metastasis, which could serve as enrollment criteria for such trials.
Overall Survival After Distant Metastasis for Patients with Oropharyngeal Squamous Cell Carcinoma (N = 621)
2001-2018
Overall Survival After Distant Metastasis Stratified by Smoking History (N = 82)
2001-2018
Overall Survival After Distant Metastasis Stratified by Lesion Number (N = 82)
2001-2018
Among patients with newly diagnosed metastatic HPV-associated SCC-OP, lesion number and smoking status were associated with significantly prolonged overall survival. These factors should be incorporated into the design of clinical trials investigating the utility of MDT, with or without systemic therapy, in this population.
