Overview

Overview

Ophthalmic Research

Cleveland Clinic Cole Eye Institute is at the forefront of innovative basic, clinical and translational research on the physiology of vision and the pathological conditions that lead to vision loss. The department of ophthalmic research is currently chaired by Bela Anand-Apte, MBBS, PhD. 

The faculty in the department are involved in multi-disciplinary and highly collaborative approaches using both basic science and clinical investigation, which serves as the basis for exploring and evaluating treatment strategies to slow and prevent vision loss. Disorders currently being investigated include retinitis pigmentosa, macular degeneration (both inherited and age-related forms), diabetic retinopathy, retinopathy of prematurity, ciliopathies, glaucoma, uveal melanoma, ambylopia and corneal disorders such as infections, wound healing and repair. There is a concentrated focus on innovative strategies to improve imaging modalities for the eye as diagnostic as well as intra-operative tools. Stem cell approaches for therapeutics are also being investigated.

One of the many strengths of the department of ophthalmology is the close interaction between basic science researchers and clinicians who are committed to achieving a common goal of preventing vision loss. This cohesive community of investigators fosters innovation through collaboration and allows the movement of ideas from both bench to bedside and bedside to bench.

Research Labs

Research Labs

Cole Eye Institute Research Labs

Angiogenesis Lab

Director: Bela Anand-Apte, MD, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.445.9739 | Lab: 216.445.1992
Email:anandab@ccf.org

Research and Publications

Laboratory Goals

  • Understanding the basic molecular mechanisms of angiogenesis with a special focus on Tissue Inhibitors of Metalloproteinases (TIMPs)
  • Examination of the physiological and pathological pathways that regulate retinal vascular leakage
  • Download full lab details and projects

Corneal Disease Diagnosis & Treatment Lab

Director: William Dupps, MD, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.444.8396
Email:duppsw@ccf.org

Research and Publications

Laboratory Goals

  • Simulation-based diagnosis and treatment of corneal disease
  • Computational modeling
  • Elasticity imaging and corneal biomechanics

Corneal Wound Healing, Diseases & Ocular Surface Lab

Director: Steven E. Wilson, MD
Cleveland Clinic
Office: 216.444.5887 | Lab: 216.444.3871
Email: wilsons4@ccf.org

Research and Publications

Laboratory Goals

  • Identify and characterize the growth factor-receptor systems through which the functions of corneal, immune, and other cells of the anterior segment of the eye are controlled during development, homeostasis, and wound healing.
  • Understand at the molecular and cellular level, the factors that lead to corneal opacity, and its resolution, after injury, surgery or infection
  • Explore the mechanism of epithelial basement membrane regeneration after injury and the importance of the corneal epithelial basement membrane in modulating epithelial-stromal interactions in the cornea, including development of myofibroblasts associated with corneal stromal opacity.
  • Download full lab details and projects

Regeneration/Cell Therapy Lab

Director: Alex Yuan, MD, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.444.0079
Email: yuana@ccf.org

Research and Publications

Laboratory Goals

Innate Immunity Lab

Director: K.P. Connie Tam, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.445.7936 | Laboratory: 216.445.7519
Email: tamk@ccf.org

Research and Publications

Laboratory Goals

Neurovascular Development Lab

Director: Sujata Rao, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.636.3156 | Fax: 216.445.3670
Email: raos7@ccf.org

Research and Publications

Laboratory Goals

Visual Electrophysiology Lab

Director: Neal S. Peachey, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.445.1942 | Lab: 216.445.1941
Email: peachen@ccf.org

Research and Publications

Laboratory Projects

Proteomics Lab

Director: John W. Crabb, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.445.0425 | Laboratory: 216.445-0424
Email: crabbj@ccf.org

Research and Publications

Laboratory Projects

Genetics Lab

Director: Stephanie A. Hagstrom, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.445.4133 | Laboratory: 216.444.5663
Email: hagstrs@ccf.org

Research and Publications

Projects

  • The function of TULP1 in photoreceptor cells of the retina
  • Pharmacogenetics of neovascular age-related macular degeneration
  • Genetic analysis of inherited retinal diseases
  • Download full lab details

Retinal Cell Biology Lab

Director: Brian D. Perkins, PhD
Cole Eye Institute, Cleveland Clinic
Office: 216.444.9683 | Fax: 216.445.3670
Email: perkinb2@ccf.org

Research and Publications

Laboratory Goals

  • Develop zebrafish models that mimic photoreceptor degeneration in childhood diseases like Joubert Syndrome, Bardet-Biedl Syndrome, and Usher Syndrome.
  • Download full lab details and projects