What do you do when your treatment plan doesn’t seem to work?
Sometimes, mental health conditions don’t respond to the first treatments. You might notice small improvements, but not enough to feel like yourself again. Or maybe nothing has changed at all. If standard care isn’t helping, it may be time for a new plan.
Cleveland Clinic’s Psychiatric Treatment-Resistance Program (PTRP) brings together the latest treatment options for conditions that haven’t improved with initial therapies. Our expert team understands how discouraging it can feel when treatments don’t bring relief, and they’re committed to helping you find solutions that offer results, hope and a new way forward.
Our PTRP team offers transcranial magnetic stimulation (TMS), intranasal esketamine, intravenous ketamine, electroconvulsive therapy (ECT), stellate ganglion block (SGB), vagus nerve stimulation (VNS) and more. We’ll explain each approach and develop a personalized treatment plan through one coordinated program. Meet our team.
Our experts work closely together to provide coordinated, personalized care. As part of your treatment, you may see specialists in psychiatry, neurology, neurosurgery, nursing, pharmacy, primary care and social work.
At Cleveland Clinic, every aspect of your treatment is tailored to your needs and delivered in a private, respectful and compassionate environment.
Treatment-resistant mental health conditions are a major focus of our research. We’re dedicated to expanding treatment options and exploring new therapies for people whose treatment hasn’t responded to standard care. Ask your care team whether you qualify for a clinical trial offering new therapies before they’re widely available.
While many of our treatments require in-person visits, we do offer virtual options for some follow-ups or quick check-ins. Your provider can tell you if a virtual visit will work for any of your appointments. Please note that if you are coming to us from out of state, you’ll need to have your initial appointment in person.
Cleveland Clinic is a trusted healthcare leader. We’re recognized in the U.S. and throughout the world for our expertise and care.
When we say a mental health condition is “treatment-resistant,” it means your symptoms haven’t improved after trying at least two standard treatments. At that point, you may benefit from a different approach beyond psychotherapy or oral medications like antidepressants.
“Treatment-resistant” doesn’t mean your condition is untreatable. It may simply mean you need a different care plan. Our team has years of experience treating treatment-resistant mental health conditions, including:
If you haven’t felt the progress you’ve hoped for, it’s important to take the next step. Our PTRP team is here to help you understand why first-line treatments may not have worked and build a plan for what to try next.
A thorough evaluation is the first step toward feeling better. During your visit, our team will ask about your health and personal and family medical history. They’ll also review past treatments, like medications and therapy, and go over new treatment options and your goals for care.
They may also order tests, including but not limited to:
When you choose Cleveland Clinic for treatment-resistant mental healthcare, you can count on a team of experts working together to plan and manage your therapy. Your PTRP team may include:
Our healthcare providers see patients at convenient locations throughout Ohio.
After your evaluation, we’ll use what we’ve learned about your health, medical history and test results to create a tailored treatment plan. Your care team will review each recommendation with you, explaining what to expect and how it may help. Our goal is to find an approach that works best for you and supports your path forward. Your care plan may include:
Neuromodulation, also called brain stimulation, uses small magnetic or electrical pulses to help restore your brain’s normal patterns of activity. They can also ease symptoms that haven’t gotten better with other therapies. There are several types, including:
Sometimes, we’ll work with your referring provider to supplement your care with additional medications. We may also recommend one of our intensive mental health programs for added support or suggest considering a clinical trial for your condition.
You don’t have to settle for treatments that aren’t working. Our PTRP team can help you explore next-level therapies and personalized care plans for treatment-resistant mental health conditions. We’ll coordinate your care into a clear plan designed to help you take control of your mental health and move forward with confidence.
To get started, your provider must submit a referral using the link below. PTRP doesn’t accept self-referrals.
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