Emergency icon Important Updates
When a routine blood test turns into a life-changing diagnosis, everything changes.

Finding out you have a rare blood cancer belonging to the group myeloproliferative neoplasms (MPNs) was probably not on your radar when you sat down and rolled up your sleeve for that blood test. Maybe you’ve been having a few symptoms you can’t shake, like feeling really tired all the time, losing weight or having night sweats. Or maybe you felt just fine. And the blood test was part of your regular checkup. But now you’ve been told you have this serious condition. What’s next? 

Not many people get this diagnosis. But if you learn you may be one of them, it’s important to have experienced healthcare providers on your side — ones familiar with these uncommon blood cancers. Cleveland Clinic’s experts are here for you. We diagnose and treat more cases of myeloproliferative neoplasms each year than many providers see in their entire careers. We’re ready to help you manage this rare condition. 

Why Choose Cleveland Clinic for Myeloproliferative Disorder Treatment?

Innovation and Research Icon

Research and innovation:

We’ve published 450+ publications and have a proven track record of discoveries and innovations. Our team leads many industry-sponsored, National Institutes of Health, Department of Defense and Leukemia & Lymphoma Society grants. And we’re part of the National Cancer Institute-funded Myeloproliferative Neoplasms Research Consortium (MPN-RC). Plus, we offer clinical trials and research registries not widely available elsewhere.

comprehensive treatment icon

Comprehensive treatment:

We have one of the world’s largest and most distinguished programs dedicated to treating all forms of myeloproliferative neoplasms. This includes polycythemia vera, myelofibrosis and essential thrombocythemia. We also offer complete care for related conditions such as anemia, thrombosis (blood clots) and acute leukemia. All treatments are tailored to your needs. Meet our team.

Quality and Focus Icon

Quality focus:

We follow the National Comprehensive Cancer Network’s recommendations for diagnosing and treating myeloproliferative neoplasms. Leading cancer experts, including Cleveland Clinic’s experts, review and update these guidelines. Your care is always based on the latest research-based practices. 

collaborative care icon

Collaborative care:

We know that it takes a team to provide the best possible care. Bringing together knowledge and experience from many different academic and clinical fields, our providers work together to offer insightful and innovative treatment options. We also work with your other providers — particularly when you live far from our offices. We’ll communicate with your provider close to home to make sure your care continues smoothly. 

national recognition icon

National recognition:

Cleveland Clinic is a trusted healthcare leader. We're recognized in the U.S. and throughout the world for our expertise and care.

Myeloproliferative Neoplasm Diagnosis at Cleveland Clinic

When you have an MPN, your body makes too many red or white blood cells or platelets — or a combination of them — in your bone marrow (spongy tissue inside your bones). It’s often a chronic (long-term) blood cancer that needs to be managed with regular treatment and follow-up.

There are different kinds of myeloproliferative neoplasms:

You may have a myeloproliferative neoplasm for months or years before symptoms appear. Often, you’ll learn you may have an MPN during routine blood tests or a physical exam. If symptoms do show up, they can be similar to ones from other health conditions. You may have:

  • Abnormally high or low blood counts (number of blood cells).
  • Bleeding problems like nosebleeds or cuts that won’t stop bleeding.
  • Blood clots that aren’t related to another underlying disease.
  • Unexplained fatigue, weight loss, fever, bruising and other lingering symptoms.
  • An enlarged spleen (splenomegaly).
  • An enlarged liver (hepatomegaly).

If your primary care provider suspects you may have a blood condition, they’ll recommend a specialist to confirm a diagnosis and start treatment. At Cleveland Clinic, we use the latest testing to help you get expert, personalized treatment.

What to expect at your first visit

Hearing you may have blood cancer can be stressful. So can a visit to a specialist and waiting for test results. We understand this and do everything we can to ease your fears, make you comfortable and help you understand what’s going on.

That’s why your provider will start your appointment by getting to know you. So they’ll ask you to share your story. Understanding how you’ve been feeling is an important part of making a diagnosis. They’ll want to know:

  • How long have you been feeling this way?
  • What kind of symptoms do you have?
  • Are your symptoms getting worse?
  • Have you had any testing before this visit?
  • Have you been diagnosed with other health conditions?
  • What health conditions do family members have/have family members had?

Your provider will also do a physical exam to check your overall health. And they’ll look for signs of a myeloproliferative neoplasm. They’ll also order tests to help them rule out other conditions and confirm a diagnosis.

Testing for myeloproliferative neoplasms

There are many tests we can do to help us make a correct diagnosis. We check your blood, do genetic testing and see how well your organs are working. All of this can help us better understand what’s going on in your body. You may have one or all of these tests, including:

Second opinions for myeloproliferative neoplasms

A blood cancer diagnosis can be a real shock. You might feel anxious, worried and overwhelmed. But it’s also important you feel confident you have a care team that listens to your concerns, answers your questions and gives you the best possible care and treatment results. That’s why we encourage second opinions. 

We have a team dedicated to diagnosing and treating rare blood cancers like myeloproliferative neoplasms. These providers take the time to answer questions, explain treatment options and offer their expertise. And because we know that cancer doesn’t wait, we try to schedule your appointment as soon as possible. A second opinion can give you peace of mind knowing that you’re in the most capable, compassionate hands. 

Meet Our Myeloproliferative Neoplasms Team

We know that a blood cancer diagnosis can affect you in many ways — physically, mentally and emotionally. When you come to Cleveland Clinic, you’ll benefit from our team-based approach to care. 

This means you’ll have all the providers you need, from different specialties, planning and managing your care based on your needs. This team stays with you throughout your journey. Our hematologists lead this team, which could also include:


We work as one team — providing expert care at convenient locations throughout Northeast Ohio. Depending on the severity of your Myeloproliferative Neoplasm, you may be able to see a provider close to home or you may need to come to our main campus for more complex care.

Myeloproliferative Neoplasm Treatment at Cleveland Clinic

We explore all options when we plan your treatment for a myeloproliferative neoplasm. We want to offer you the best chance for a long, healthy life.

Treatment for myeloproliferative neoplasms focuses on relieving symptoms, slowing disease progression and reducing your risk for complications like acute myeloid leukemia.

For all types of myeloproliferative neoplasms, the only known cure is allogeneic stem cell transplantation. But not everyone can go through this process. There are other ways to manage these conditions if a stem cell transplant isn’t an option. We make sure you understand all treatment options for your type of MPN.

We can use different treatments to reduce the number of blood cells, provide symptom relief and avoid complications. Depending on the type of MPN, your treatment may include:

Living With Myeloproliferative Neoplasms

While some myeloproliferative neoplasms can be cured and go away, others may be chronic or come back after treatment (recur). You’ll have regular check-ups with your care team and frequent testing to keep an eye on your health, and to manage or prevent symptoms — and see if your MPN recurs. If it does, we can start treatment right away. 

Having blood cancer can be stressful. And we’re here to help you manage that stress. There are many ways to do that — personalized eating and exercise plans, support groups or psychotherapy, to name a few. You can get the care you need for the whole you when you need it.

Taking the Next Step

No one plans on hearing, "You have blood cancer." But when you do, you don’t have to go through this journey on your own. Cleveland Clinic’s team of dedicated rare blood cancer healthcare providers and other specialists are here to guide you through each step. They work together (and with you) to find the best treatments and compassionate support so you can thrive as you move forward. 

Getting an appointment with Cleveland Clinic myeloproliferative neoplasm experts is easy. We’ll help you get care.


Getting an appointment with Cleveland Clinic myeloproliferative neoplasm experts is easy. We’ll help you get care.

Manage your Cleveland Clinic account. Find billing information and financial assistance, plus FAQs.

Billing & Insurance

Manage your Cleveland Clinic account. Find billing information and financial assistance, plus FAQs.

Securely access your personal health information at any time, day or night.


Securely access your personal health information at any time, day or night.

Woman with a shaved head due to chemotherapy treatment is hopeful following remission.


Learning you have cancer can be stressful, shocking and challenging. From the moment you get the news, you're a survivor. As you face the challenges that go along with cancer treatment and recovery — physical and emotional — we’ll be right there with you.

At Cleveland Clinic, survivorship care is one part of your journey. We offer a wide range of services, resources, clinics and support groups to help with any physical, emotional, financial and spiritual needs you might have related to your cancer diagnosis. Lending a helping hand along the way, we want you to not only survive, but thrive on this journey and beyond.

Health Library
Back to Top