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Your liver works hard. And it usually bounces back from injuries and illness. But sometimes your liver works too hard, and it can’t always recover.

Because this important organ constantly filters toxins out of your blood, when it’s not doing well, neither are you. Advanced liver disease can change your life, leaving you feeling itchy, tired and sick and bracing for the worst.

At Cleveland Clinic, we’re one of the nation’s largest liver transplant programs. We specialize in minimally invasive techniques and offer innovative surgeries like living donor liver transplants. Our knowledgeable team will guide you through the entire transplant process, answering all of your questions and supporting you the whole time.

Why Choose Cleveland Clinic for Liver Transplant Surgery?

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Trusted experts:

We’ve done thousands of liver transplants and have experience that few hospitals can match. Our Liver Transplant Program is one of the largest in the country and uses the latest techniques for high success rates. Meet our team.

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Industry leaders:

Our surgical team pioneered and perfected the use of living donor liver transplants, which increase the chance of getting a lifesaving liver transplant before you’re too sick for surgery. We’re among the first programs in the United States and one of the few hospitals worldwide to do living donor surgery using a minimally invasive (laparoscopic) technique.

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Specialized knowledge:

We have specialists in every aspect of liver disease. We offer care that slows liver disease progression and helps some people avoid a liver transplant. If you do need a transplant, you’ll be treated by some of the world’s top experts.

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Innovation and research:

Our liver transplant team is leading research and developing technologies that improve outcomes and quality of life for transplant patients. We were the first hospital in the nation to use ex vivo liver perfusion (keeping the donated liver warm by circulating blood through it) to extend the life of livers that come from deceased donors — which were once unsafe to use. We’re also researching ways to use transplants to treat certain cancers.

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National recognition:

Cleveland Clinic is a trusted healthcare leader. We're recognized in the U.S. and throughout the world for our expertise and care.

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Virtual visits:

For your convenience, follow-up visits can often be done virtually. All you need is an internet connection, a smartphone, tablet or computer. Virtual visits are an easy and safe alternative to an in-person visit. They can be especially helpful if you don’t live close to Cleveland Clinic.

Liver Transplant Surgery at Cleveland Clinic

No two liver transplants are the same. Our liver disease and transplant experts focus entirely on you and offer support before, during and after surgery.

Meet our team

Our team approach helps you recover and thrive — physically and emotionally. We work together to design a personalized treatment plan based on your unique needs, overall health and long-term goals. Your liver transplant team includes:

  • Liver transplant surgeons.
  • Nurses specially trained in transplant surgery.
  • Hepatologists (liver specialists).
  • Pharmacists.
  • Dietitians.
  • Social workers.

There are three different types of liver transplant surgery options we can choose from:

Living donor liver transplant

In a living donor liver transplant, we give you part of a healthy living person’s organ. Your liver has two lobes, right and left, and each has its own blood flow. Because healthy liver tissue quickly regrows, we can take one of the lobes from your living donor and give it to you, leaving the other lobe in the donor.

Our surgical team pioneered and perfected this technique, which lets you avoid waiting for (maybe) years for a donor liver from someone who’s died. This means you can have surgery in the earlier stages of your disease and get better outcomes. Because the liver you receive is taken from a healthy living donor instead of a deceased donor, the quality of the liver is better.

Your donor could be a relative, friend or even a person you don’t know. Your living donor must be healthy and have a blood type that matches yours. If your blood type doesn’t match with your recipient, you can participate in the Liver Paired Exchange program. This program was started to increase the chance for potential living liver donors who are approved to be liver donors but who can’t donate their liver to their original intended recipient for various reasons. The program involves two incompatible pairs, which become compatible pairs by “swapping.”

You and your donor will have surgery at the same time. Cleveland Clinic is one of the few places — and the most active center in the United States — to offer minimally invasive surgery for living donors.

Minimally invasive laparoscopic donor surgery

At Cleveland Clinic, we use minimally invasive laparoscopic donor surgery (keyhole surgery) instead of traditional (open) surgeries. During open surgery, the surgeon has to make a large incision (cut) in the donor’s belly to remove part of their liver. Doing a minimally invasive procedure means much smaller cuts. Laparoscopic techniques reduce the risk of bleeding, resulting in smaller scars and speeding up the donor’s recovery.

Your surgeon will use a thin, telescopic rod with a camera attached to it (laparoscope) to see inside your abdomen. They’ll make several small incisions (usually up to five) to do this. One is for the camera and the others are for the surgical tools your surgeon will use during the operation.

Patients usually require only half the amount of pain medication and recover twice as fast compared to those who’ve had open surgery.

Your provider will let you know before surgery how long you’ll need to stay in the hospital after your operation.

Deceased donor liver transplant

Liver transplants from donors who’ve died make up the majority of these surgeries. All liver transplant candidates will join the national waiting list to get matched with a donor’s liver.

A lot of factors come into play to find the right match for you — things like how sick you are, your body size and your blood type.

This means you could wait a few days, months or even several years for a new liver match. And joining the list doesn’t guarantee you’ll get a deceased donor liver — although the sicker you are, the faster you can move higher up on the list. Your provider will talk with you about how the list works and what to expect.

If and when a matching liver becomes available, things will move fast. You’ll need to come in right away. When you get there, you’ll get some standard health screenings and meet with your surgeon and anesthesiologist to start preparing for surgery.

Ex vivo liver perfusion

Cleveland Clinic was the first hospital in the U.S. to transplant a human liver using ex vivo liver perfusion. You might be thinking “what is that and how is it different?” This is a groundbreaking new technology that lets our surgeons extend the life of livers that weren’t safe to use in the past. How does this work? We use a machine to pump blood through the donated organ — keeping it warm. Using this technique increases the number of organs available for transplant surgery. This shortens the waiting time for patients and saves more lives.

Pediatric Liver Transplant Surgery at Cleveland Clinic

Adults aren’t the only ones who might need a liver transplant. Some kids also do, and Cleveland Clinic Children's is here to help them and their families during this stressful time.

We have one of the most experienced pediatric liver transplant teams in the country, with certified pediatric transplant hepatologists and surgeons at the ready. Your child will have the same team of providers from the time of referral and beyond.

During the first visit, you and your child will meet with their whole team. We’ll go over all the treatment options and what to expect throughout this journey. Your child will have a physical exam and some bloodwork done so our team can get a better idea of their overall health and how far their liver disease has progressed.

Pediatric liver transplant surgery requires special skill sets to make it successful because children aren’t small adults. Your child will receive a smaller portion of a liver from a live or deceased donor or a whole liver from a deceased donor of a matching size.

Pediatric transplant pharmacists, dietitians, psychologists and social workers are also part of your child’s care team. Throughout the whole process, we’re there to support you and your child — treating the whole person, not just the liver.


Our healthcare providers see patients at convenient locations throughout Northeast Ohio and Florida.

Liver Transplant Recovery and Support at Cleveland Clinic

Typically, you’ll be in intensive care for a few days while your providers keep an eye out for any complications. After leaving intensive care, you’ll typically stay another one to three weeks in the hospital to continue your recovery.

Your provider will talk with you about how long you’ll need to stay in the hospital and in the area after your transplant. This depends on how sick you were before your transplant and if you’re having any problems after the operation.

The promising news is that when discharged, most patients walk out our doors and eventually return to their daily activities — often in three months to less than a year. If you need more medical support, you may stay in a rehabilitation facility before going home to help get your strength back. But our care doesn’t stop when you leave. We’re here to support you throughout your entire journey, from your first visit — and beyond.

When you go home, you’ll follow up with your providers often, in-person or through virtual visits, and get regular blood tests. You’ll also take medications to help you recover and prevent your body from rejecting your new liver. You’ll need to take some of these medications for the rest of your life. You’ll work with a post-transplant coordinator who’ll keep in touch with you and look at your lab work, help you with appointments and more.

Mental, emotional and spiritual support

If you feel like you need to talk to someone about how you’re feeling emotionally at any point during your transplant journey, we can also connect you with mental health counselors, social workers or a spiritual advisor. We also have American Liver Foundation and TRIO (Transplant Recipient International Organization) support groups.

Traveling for liver transplant surgery

Traveling for liver transplant surgery can put a whole other level of stress on the process. We understand that. If you’re coming to us from another city, state or even another country, we’re here to help make things as easy and convenient as possible for you. We can give you recommendations on where to stay, where to eat and shop, and how to get to and from the airport or just find your way around any of our hospitals.

If you’re an international patient, our experienced and compassionate Global Patient Services (GPS) team will help you navigate the Cleveland Clinic health system. They’ll connect you with the healthcare providers you need, help make appointments, provide language translation services and coordinate follow-up care when it’s time to go home.

Taking the Next Step

Preparing to get a liver transplant can be overwhelming — and life-changing. But you don’t have to go through it alone. Our experienced team of healthcare providers is here to help answer your questions and create a personalized treatment plan for you. We’ll help you find the right donor liver and get you on the road to recovery so you can enjoy life again. We know it’s a long journey. That’s why we’ll provide compassionate care and support every step of the way.

Scheduling an appointment with Cleveland Clinic’s liver transplant experts is easy. We’ll help you get the care you need.


Scheduling an appointment with Cleveland Clinic’s liver transplant experts is easy. We’ll help you get the care you need.

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