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Department Breast Services
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Acute Care Surgery
  • Advanced Laparoscopic Surgery
  • Advanced Polypectomy
  • Anesthesia For Organ Transplant
  • Anorectal Surgery
  • Breast Cancer Prevention
  • Breast Cancer Risk Assessment
  • Breast Diagnostics
  • Breast Exam
  • Breast Health
  • Breast Pathology
  • Cancer Center
  • Cancer Risk Assessment
  • Cancer Screening
  • Clinical Breast Examination
  • Department of General Surgery
  • High Risk Breast Cancer
  • Mammogram
  • Screening and Testing
  • Self Breast Exam
View all 20 Treatment & Services +

Specialty in Diseases & Conditions

  • Abnormal Breast MRI
  • Abnormal Breast Ultrasound
  • Abnormal Mammogram
  • Adrenal Cancer
  • Adrenal disorders
  • Adrenal Mass
  • Adrenocortical Carcinoma
  • Ascites
  • Atypical Lobular Hyperplasia (ALH)
  • Axillary Mass - Pain/Swelling
  • Benign Breast Disease
  • Bile Leak
  • Breast
  • Breast - Nodules
  • Breast Cancer - High Risk
  • Breast Cancer - Mass, Lump or Swelling
  • Breast Disease
  • Breast Infections
  • Breast Lump
  • Breast Pain
  • Cancer - Prevention
  • Cancer Genomic Medicine
  • Dilated Breast Duct
  • Family Cancer History
  • Family History of Breast Cancer
  • Fibrocystic Breast Changes
  • Gynecomastia
  • Hereditary Cancer Risk Management
  • Hereditary Cancers
  • Lymphadenopathy
  • Lymphedema
  • Mastitis
  • Nipple Discharge
View all 33 Specialties +


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About Holly Pederson, MD

Holly Pederson, MD, is a Staff Physician and Director of Medical Breast Services in the Breast Center.  She is an Associate Professor at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

After receiving her BA in Biochemistry from the University of California-Santa Barbara where she received the distinction of Phi Beta Kappa, Dr. Pederson earned her medical degree from the University of California-San Francisco School of Medicine where she was recognized in the Alpha Omega Alpha honors society. She completed her internship and residency at the University of California San Francisco Medical Center in Internal Medicine, and in 2008 completed a clinical fellowship in Genomics at Cleveland Clinic.  She directs the Medical Breast Program and is active in clinical research.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Residency - University of California San Francisco Medical Center
Internal Medicine
San Francisco, CA USA

Internship - University of California San Francisco Medical Center
Internal Medicine
San Francisco, CA USA

Medical Education - University of California-San Francisco School of Medicine
San Francisco, CA USA

Undergraduate - University of California-Santa Barbara
Biochemistry/Molecular Biology
Santa Barbara, CA USA

Additional Training

  • Dr. Pederson has a special interest and subspecialty training in hereditary breast cancer.

Professional Highlights

  • Research and Publications: 

    1. Smedira Holly Jane, “Practical Issues in Counseling Healthy Women About Their Breast Cancer Risk and
    Use of Tamoxifen Citrate,” Arch Intern Med 2000;160:3034-3042
    2. Smedira, Patrick, Rybicki and Crowe, “Integrating Medical Breast Specialists into the Traditional Breast
    Center Practice Model: A Review of 11 Years of Experience” Arch Intern Med 2008; 168:2042-2045
    3. Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, Milas K, Pederson H, Remzi B, Orloff MS, Eng C. “A Clinical Scoring System for Selection of Patients For PTEN Mutation Testing is Proposed on the Basis
    Of a Prospective Study of 3042 Probands” The American Journal of Human Genetics  2011: 88, 1-15
    4. Pederson HJ, O'Rourke C, Lyons J, Patrick RJ, Crowe JP Jr, Grobmyer SR. "Time Related Changes in Yield and Harms of Screening Breast MRI" Clin Breast Cancer. 2015 Oct; 15(5): 348-352.  
    5. Pederson HJ, Padia S, May M, Grobmyer S, “Management of Patients at Genetic Risk for Breast Cancer”, Cleveland Clinic Journal of Medicine  2016.  83;(3): 199-206.
    6. McCray D,  Grobmyer S, Pederson H “Impact of Value Based Breast Cancer Care Pathway on Pre-Operative Breast MRI Utilization”  Gland Surgery 2017 Feb; 6(1): 57-63 
    7. Donaldson AR, McCarthy C, Goraya S, Pederson HJ, Sturgis CD, Grobmyer SR, Calhoun BC, “Breast Cancer Risk Associated with Atypical Hyperplasia and Lobular Carcinoma in Situ Initially Diagnosed on Core Needle Biopsy,” Cancer 2018 Feb 1; 124 (3): 459-465.
    8. Pederson HJ, Gopalakrishnan D, Noss R, Yanda C, Eng C, Grobmyer SR, “Impact of Multigene Panel Testing on Surgical Decision Making in Breast Cancer Patients,” . J Am Coll Surg. 2018 Apr, 226(4):560-565.
    9. Pederson HJ, “Breast Cancer Risk Assessment and Treatment:  Current Concepts in Genetics and Genomics,”  Contemporary OB/GYN December 2017.  
    10. Pederson HJ, Hussain N, Noss R, Yanda C, O’Rourke C, Eng C and Grobmyer SR “Impact of an embedded genetic counselor on breast cancer treatment,” Breast Cancer Res Treat. 2018 May;169 (1): 43-46.
    11. Pederson HJ “Who needs breast cancer genetics testing?” OBG Manag. 2018 June; 30;(6) 34-39
    12. Grobmyer SR, Pederson HJ, Valente SA, Al-Hilli A, Radford D, Djohan R, Yetman R, Eng C and Crowe J. “Evolving Indications and Long Term Oncologic Outcomes of Risk Reducing Bilateral Nipple Sparing Mastectomy” BJS Open . 2018 Nov 26;3(2): 169-173.
    13. Pederson HJ. “Clinical care of women with intermediate breast cancer risk” Menopause. 2019 Jul; 26(7): 797-799
    14. Modesitt S, Pederson HJ, Adkins RT. “Practical Cancer Genetics and Genomics in Women’s Health”. Clin Obstet Gynecol. 2019 Jul 11.


  • Internal Medicine

Specialty Interests

Family history of breast cancer and Breast cancer risk assessment and prevention, Breast diagnostics, Benign breast disease, Breast cancer genetics and High risk management, Hereditary cancer risk management

Innovations & Patents

  • Dr. Pederson helped to create the Medical Breast Program at Cleveland Clinic in 1997, and now offers a subspecialty  Hereditary High Risk Clinic for patients with identified genetic mutations predisposing to breast cancer, family members of mutation carriers or patients from families with a strong family history of breast cancer. 


  • American Society of Clinical Oncology
  • American Society of Breast Surgeons
  • Case Comprehensive Cancer Center - Cancer Genetics Program 
Research & Publications

Research & Publications

See publications for Holly Pederson, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 11/14/2021, Dr. Pederson has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Pederson receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Myriad Genetics, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

202 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

35 Patient Comments

Reviewed on Oct 20, 2021

Dr. Pederson is by far the best doctor I've ever dealt with. She is so kind and caring, along with being highly knowledgeable. She makes me feel comfortable and safe.

Reviewed on Oct 20, 2021

Provider was excellent on the phone call visit. Video visit was unsuccessful.

Reviewed on Oct 8, 2021

Dr. Pederson is excellent

Reviewed on Oct 4, 2021

Both the doctor and her NP were amazing. They took their time to examine and gather information for best next steps. I appreciated their amazing bed side manner.

Reviewed on Aug 26, 2021

Dr. Pederson is simply the best. I'm a provider myself and she is hands down the best provider I've ever seen. She is so knowledgeable yet down to earth, presents data but explains things so well. I really feel so lucky to have her.

Reviewed on Aug 26, 2021

I have the highest regard for Dr. Pederson. I felt that I was slightly rushed toward the end of the appointment but my guess is that she had another appointment right after mine.

Reviewed on Aug 25, 2021

Dr. Pederson is the epitome of a health care professional, caring and personal and truly invested in people's well being! Even through the video appointment, the service did not disappoint!

Reviewed on Aug 10, 2021

Dr Holly Pederson was off her game with me, my issues and medication

Reviewed on Jul 29, 2021

Dr. Holly Pederson is always professional, compassionate, easy to discuss concerns and questions with, and friendly. I value her expertise!

Reviewed on Jul 28, 2021

Dr Pederson spent over ten minutes on the phone with me. She took time to listen to my concerns and to explain her thought process for my treatment in detail. She is an exceptional doctor.

Reviewed on Jul 22, 2021

My Doctor is always kind and respectful. She always shows great concern and explains everything thoroughly. I always feel confident in my care with her.

Reviewed on Jul 22, 2021

Excellent experience. Dr. P. Is the BEST. She explains everything fully and answers questions and is very knowledgeable and provides excellent care and direction and follow-up.

Reviewed on Jul 21, 2021

Excellent Doctor ! Love her

Reviewed on Jul 21, 2021

Great doctor, staff was extremely friendly

Reviewed on Jul 21, 2021

Doctor spent quality time explaining everything to me.

Reviewed on Jul 21, 2021

Dr. Pederson is a wonderful doctor who is both intelligent, friendly, communicates well, listens and responds with kindness and compassion. She's just fantastic all around.

Reviewed on Jun 24, 2021

Dr Pederson is outstanding!

Reviewed on Jun 23, 2021

excellent experience with the doctors

Reviewed on Jun 21, 2021

I love Dr. Pederson. She is thorough and kind. Her staff is helpful and friendly.

Reviewed on Jun 16, 2021

Dr. Pederson is always so very kind.

Reviewed on May 25, 2021

Dr. Peterson has very limited access, as a provider she is great, but would not make the recommendation as she does not have access for both new and follow-up patients

Reviewed on May 20, 2021

Love the doctor but I feel like I rushed my appointment by not asking a lot of questions because the doctor was two hours behind. I live in Erie and I need to get home. I do really like the doctor. She was great

Reviewed on May 19, 2021

I feel very Blessed that Dr Peterson came so highly recommend to me (I now see why) I feel I was in the best hands possible.

Reviewed on May 18, 2021

Helpful, respectful and Dr Pederson is very thorough and you know she is giving expertise assessment and direction.

Reviewed on Apr 7, 2021

I love love love Dr. Pederson. I live out of state and cannot visit her in person but the video visits have made it possible for us to connect and discuss my concerns.

Reviewed on Apr 7, 2021

I sought out Dr. Pederson for her knowledge on the use of the medical prevention of breast cancer in BRCA patients. But she's actually given me more than just technical type of knowledge. She helps me explore the issues surrounding this hereditary diagnosis beyond just prescribing medication.

Reviewed on Mar 30, 2021

Dr. Pederson always goes above and beyond. She comes into the exam room well prepared with knowledge of my medical history. She provides outstanding care.

Reviewed on Mar 23, 2021

dr Pederson is the best doctor I have ever had. she is very knowledgeable and shares her knowledge with me. She always reads up on my history and takes all the time I need with my visit and answering my questions.

Reviewed on Mar 2, 2021

Dr. Pederson listens as much as she speaks...and she remembers who you are. There is respect for me as an individual and a genuine feeling on my end that she cares.

Reviewed on Feb 23, 2021

this provider could have easily referred me to my pcp but has kept me throughout and the care is superior

Reviewed on Feb 23, 2021

Very happy I got to see the doctor I wanted

Reviewed on Jan 27, 2021

Both Dr. Pederson and her PA were very professional and polite. They were very thorough and answered all of my questions.

Reviewed on Jan 25, 2021

I'm so happy & grateful to have such a kind, competent & compassionate Dr. She listens to me & following her suggestions has really helped me. Also, Jody at the desk rocks!

Reviewed on Jan 7, 2021

Dr. Pederson is one of the most knowledgeable and caring physicians. She makes me feel comfortable, answers questions, and is very trustworthy. Dr. Pederson is definitely a top-notch physician who I would highly recommend to others.

Reviewed on Jan 7, 2021

Dr. Pederson is a very caring, knowledgeable, and trustworthy physician. She cares about her patients and their concerns. Dr. Pederson is top-notch and I would definitely recommend her to others.

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