Department Breast Services
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Breast Cancer Risk Assessment
  • Breast Diagnostics
  • Breast Health
  • Cancer Center
View all 4 Treatment & Services +

Specialty in Diseases & Conditions

  • Breast Disease
  • Breast Lump
  • Breast Pain
  • Family History of Breast Cancer
  • Gynecomastia
  • Hereditary Cancer Risk Management
  • Nipple Discharge
View all 7 Specialties +


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About Holly Pederson, MD

Holly Pederson, MD, is a Staff Physician and Director of Medical Breast Services in the Breast Center.  She is an Associate Professor at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

After receiving her BA in Biochemistry from the University of California-Santa Barbara where she received the distinction of Phi Beta Kappa, Dr. Pederson earned her medical degree from the University of California-San Francisco School of Medicine where she was recognized in the Alpha Omega Alpha honors society. She completed her internship and residency at the University of California San Francisco Medical Center in Internal Medicine, and in 2008 completed a clinical fellowship in Genomics at Cleveland Clinic.  She directs the Medical Breast Program and is active in clinical research.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Residency - University of California San Francisco Medical Center
Internal Medicine
San Francisco, CA USA

Internship - University of California San Francisco Medical Center
Internal Medicine
San Francisco, CA USA

Medical Education - University of California-San Francisco School of Medicine
San Francisco, CA USA

Undergraduate - University of California-Santa Barbara
Biochemistry/Molecular Biology
Santa Barbara, CA USA

Additional Training

  • Dr. Pederson has a special interest and subspecialty training in hereditary breast cancer.

Professional Highlights

  • Research and Publications: 

    1. Smedira Holly Jane, “Practical Issues in Counseling Healthy Women About Their Breast Cancer Risk and
    Use of Tamoxifen Citrate,” Arch Intern Med 2000;160:3034-3042
    2. Smedira, Patrick, Rybicki and Crowe, “Integrating Medical Breast Specialists into the Traditional Breast
    Center Practice Model: A Review of 11 Years of Experience” Arch Intern Med 2008; 168:2042-2045
    3. Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, Milas K, Pederson H, Remzi B, Orloff MS, Eng C. “A Clinical Scoring System for Selection of Patients For PTEN Mutation Testing is Proposed on the Basis
    Of a Prospective Study of 3042 Probands” The American Journal of Human Genetics  2011: 88, 1-15
    4. Pederson HJ, O'Rourke C, Lyons J, Patrick RJ, Crowe JP Jr, Grobmyer SR. "Time Related Changes in Yield and Harms of Screening Breast MRI" Clin Breast Cancer. 2015 Oct; 15(5): 348-352.  
    5. Pederson HJ, Padia S, May M, Grobmyer S, “Management of Patients at Genetic Risk for Breast Cancer”, Cleveland Clinic Journal of Medicine  2016.  83;(3): 199-206.
    6. McCray D,  Grobmyer S, Pederson H “Impact of Value Based Breast Cancer Care Pathway on Pre-Operative Breast MRI Utilization”  Gland Surgery 2017 Feb; 6(1): 57-63 
    7. Donaldson AR, McCarthy C, Goraya S, Pederson HJ, Sturgis CD, Grobmyer SR, Calhoun BC, “Breast Cancer Risk Associated with Atypical Hyperplasia and Lobular Carcinoma in Situ Initially Diagnosed on Core Needle Biopsy,” Cancer 2018 Feb 1; 124 (3): 459-465.
    8. Pederson HJ, Gopalakrishnan D, Noss R, Yanda C, Eng C, Grobmyer SR, “Impact of Multigene Panel Testing on Surgical Decision Making in Breast Cancer Patients,” . J Am Coll Surg. 2018 Apr, 226(4):560-565.
    9. Pederson HJ, “Breast Cancer Risk Assessment and Treatment:  Current Concepts in Genetics and Genomics,”  Contemporary OB/GYN December 2017.  
    10. Pederson HJ, Hussain N, Noss R, Yanda C, O’Rourke C, Eng C and Grobmyer SR “Impact of an embedded genetic counselor on breast cancer treatment,” Breast Cancer Res Treat. 2018 May;169 (1): 43-46.
    11. Pederson HJ “Who needs breast cancer genetics testing?” OBG Manag. 2018 June; 30;(6) 34-39
    12. Grobmyer SR, Pederson HJ, Valente SA, Al-Hilli A, Radford D, Djohan R, Yetman R, Eng C and Crowe J. “Evolving Indications and Long Term Oncologic Outcomes of Risk Reducing Bilateral Nipple Sparing Mastectomy” BJS Open . 2018 Nov 26;3(2): 169-173.
    13. Pederson HJ. “Clinical care of women with intermediate breast cancer risk” Menopause. 2019 Jul; 26(7): 797-799
    14. Modesitt S, Pederson HJ, Adkins RT. “Practical Cancer Genetics and Genomics in Women’s Health”. Clin Obstet Gynecol. 2019 Jul 11.


  • Internal Medicine

Specialty Interests

Family history of breast cancer and Breast cancer risk assessment and prevention, Breast diagnostics, Benign breast disease, Breast cancer genetics and High risk management, Hereditary cancer risk management

Innovations & Patents

  • Dr. Pederson helped to create the Medical Breast Program at Cleveland Clinic in 1997, and now offers a subspecialty  Hereditary High Risk Clinic for patients with identified genetic mutations predisposing to breast cancer, family members of mutation carriers or patients from families with a strong family history of breast cancer. 


  • American Society of Clinical Oncology
  • American Society of Breast Surgeons
  • Case Comprehensive Cancer Center - Cancer Genetics Program 
Research & Publications

Research & Publications

See publications for Holly Pederson, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 1/10/2019, Dr. Pederson has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Pederson receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Myriad Genetics, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

304 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 4.9
Knows Medical History 5
Time Spent with Patient 4.8
Patient Rating of Doctor 4.9

47 Patient Comments

Reviewed on Sep 18, 2019

physician is wonderful as always at every visit I have had with her. very caring and listens to my concerns, easy to talk to

Reviewed on Sep 18, 2019

Dr. and Nurse very personable.

Reviewed on Sep 11, 2019

I have already recommended Dr. Pederson to some of my friends.

Reviewed on Sep 4, 2019

She is one of the best doctors I have ever had. As I went through challenges in my health, she was always there with expertise, kindness, caring and made me feel I was in the best hands. And she continues to be a great advocate. And I am happy she has seen my daughter as well.

Reviewed on Aug 30, 2019

Dr Holly and Erika were very helpful. They informed us of risks, tests, procedures, and possible results. Clearly both are well educated and do an excellent job of explaining and putting patients at ease

Reviewed on Aug 5, 2019

Dr. Peterson is always very professional.

Reviewed on Aug 5, 2019

Dr Peterson is very skilled and professional..Shows care for her patients.

Reviewed on Jul 31, 2019

Dr. Pedorson is a very empathetic, caring and knowledgeable physician. She is prepared and informed when she arrives in the exam room to speak with you (she has actually read my medical record).

Reviewed on Jul 25, 2019

felt confident that the plan of action the doctor suggested was reasonable..comforting

Reviewed on Jul 25, 2019

I was very please with the care and kindness of the Doctor. I make the trip of 4 hours each way and will continue to do so to see Dr. Pederson. She made me feel comfortable and was able to explain everything very well to me

Reviewed on Jul 25, 2019

Dr Pederson is the absolute best. I left another hospital system for her and am so glad I did.

Reviewed on Jul 18, 2019

she follows up on my problems even if they are not related to her specialty. if she hears about it, she wants to make sure it's been taken care (even if by other providers). she is amazing.

Reviewed on Jul 10, 2019

Dr. Pederson is very easy to talk to and very informative.

Reviewed on Jul 10, 2019

I can't imagine going to another facility. From Barbara at the front desk, to Mary Ann Rubin (Nurse), Paulette( Breast imaging) and Dr. Pederson I feel very lucky to have such amazing care at the Breast Center.

Reviewed on Jun 27, 2019

With Dr. Grobmeyer leaving, I was given option of other physicians. I prefer a male and was a bit disappointed that of 5 listed, all were female. Thank you. Dr. Pederson did a thorough job

Reviewed on Jun 27, 2019

Dr Pederson's NP was superb: professional and courteous. Excellent at explaining procedures and addressing my concerns.

Reviewed on Jun 26, 2019

I have been with *Dr. Pederson for well over 5 yrs. She is an excellent physician and I feel very fortunate to even her as my breast doctor!!

Reviewed on Jun 20, 2019

Holly Pederson is an exceptional doctor in every way! She is knowledgeable, professional, and extremely caring.

Reviewed on Jun 19, 2019

Dr. Pederson is a great provider; however, I think she is overbooked at the Main Campus. I didn't have this trouble at the Beachwood facility.

Reviewed on Jun 5, 2019

Dr. Pederson has always shown compassion and concern at all my visits.

Reviewed on Jun 4, 2019

Dr. Pederson is amazing. She always answers every question, and educates me with everything relevant from her research. I truly feel she knows me personally even though I only see her twice a year. She is friendly, informative and I am so thankful for her care.

Reviewed on May 10, 2019

I'm very satisfied with my visit to Dr Pederson.From the receptionist until seeing her all the staff was amazing!!Dr Pederson is just very nice and knowledgeable.I'm very happy that I saw her as a Dr.I appreciate all her advises!!

Reviewed on May 10, 2019

I already have recommended Dr Pederson!!! I'm very happy that I went to see her. I'm more in peace and ready to go and have done what she recommended me.She's very professional, kind and very knowledgeable.I'm very satisfied with my visit.

Reviewed on May 8, 2019

Dr Pederson and her staff exceed my expectations every time.

Reviewed on Apr 29, 2019

Dr. Pederson is a wonderful, caring person. She is very knowledgeable, professional, kind. You can tell she is a genuine person who cares about what she does

Reviewed on Apr 15, 2019

Dr. Pederson contacted my primary care physician about an issue and really appreciated her proactive action.

Reviewed on Apr 3, 2019

I am always excited to see Dr. Peterson! She is very professional and caring with me. She is upbeat and always makes me feel like I am the only patient she has. When I have had to email her with questions she always answers right away. I know if any problems should arise in the future with my breast issue I will be in good hands.

Reviewed on Mar 13, 2019

Dr.Pederson and her staff are so kind and caring. I feel very confident in their care.

Reviewed on Mar 6, 2019

Dr. Peterson goes above and beyond every time and you know she is really listening and invested in you as a patient. I have been seeing her for years and can't speak highly enough of her!

Reviewed on Feb 22, 2019

Dr. Pederson is simply amazing. She is kind, down to earth and genuinely cares!

Reviewed on Feb 22, 2019

I didn't appreciate that the doctor said nothing and showed no concern for the wait I had to see her.

Reviewed on Feb 22, 2019

once in the exam room I had to wait 40 minutes to see the doctor

Reviewed on Feb 21, 2019

Excellent and very knowledgeable physician. Dr. Pederson answered all my questions and made me feel very comfortable. Dr. Pederson is definitely top-notch in her specialty. The Cleveland Clinic is very fortunate to have her on their staff. I would highly recommend her to my family and friends.

Reviewed on Feb 21, 2019

Dr. Pederson has a great staff. Annette is very friendly and helpful.

Reviewed on Feb 20, 2019

Dr. Pederson is empathetic, supportive, kind and includes the patient is all decision making.

Reviewed on Feb 13, 2019

Thank you so much for Dr. Pederson . She's wonderful. She never makes you feel rushed and takes time to answer all questions.

Reviewed on Jan 30, 2019

She listened to my concerns and when the doctor came in she was fully aware without me repeating myself

Reviewed on Jan 22, 2019

I was having a very bad day and Dr. Pedersen and Sue were both very compassionate and kind to me during my appointment and I was very grateful.

Reviewed on Jan 17, 2019

Dr Pederson is,a very personable person. This is very much needed especially in her field

Reviewed on Jan 15, 2019

Dr. Pederson is always up to date on latest research. Always involves me in decision making & respects my decisions. I have recommended her to many people.

Reviewed on Jan 11, 2019

Dr. Pederson was amazing, it was a very pleasant experience. She was concerns, compassionate and took the time to listen. I have told several people about her and I am amazed at how many people are familiar with her and all have glowing things to say about her.

Reviewed on Dec 26, 2018

I consider Dr. Pederson to be the best in her field and I feel so lucky to be her patient. Breast cancer runs in my family and her expertise has put my mind at ease.

Reviewed on Nov 28, 2018

I have been a patient of the Cleveland Clinic with mixed results. There are some amazing doctors on your staff and Dr. Pederson is definitely one of them. She makes me feel like a person and not a number in your system. She listens well, makes me feel cared for, and answers all of my questions. She also educates me on my health and provides advice that I trust. I am so grateful to be her patient. She is a wonderful doctor and I hope that she is as valued by her employers as much as she is valued by her patients.

Reviewed on Nov 26, 2018

I will miss Dr. Pederson as she moves into another position. she's an outstanding provider of health care and makes me feel safe and cared about. that's a lot in this day of shorter medical visits.

Reviewed on Nov 23, 2018

Dr. Penderson is so compassionate and knowledgeable. I felt at ease with her.

Reviewed on Nov 21, 2018

I was very happy with Dr Pederson and look forward to continuing my care with her. I was impressed with how well she knew my medical history as this was the first time I've met her. I feel I am in the best hands possible and am very thankful for that.

Reviewed on Nov 5, 2018

Dr. Pederson is a knowledgeable and professional healthcare providers.

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