Department Breast Services
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Acute Care Surgery
  • Advanced Laparoscopic Surgery
  • Advanced Polypectomy
  • Anesthesia For Organ Transplant
  • Anorectal Surgery
  • Breast Cancer Prevention
  • Breast Cancer Risk Assessment
  • Breast Diagnostics
  • Breast Exam
  • Breast Health
  • Breast Pathology
  • Cancer Center
  • Cancer Risk Assessment
  • Cancer Screening
  • Clinical Breast Examination
  • Department of General Surgery
  • High Risk Breast Cancer
  • Mammogram
  • Screening and Testing
  • Self Breast Exam
View all 20 Treatment & Services +

Specialty in Diseases & Conditions

  • Abnormal Breast MRI
  • Abnormal Breast Ultrasound
  • Abnormal Mammogram
  • Adrenal Cancer
  • Adrenal disorders
  • Adrenal Mass
  • Adrenocortical Carcinoma
  • Ascites
  • Atypical Lobular Hyperplasia (ALH)
  • Axillary Mass - Pain/Swelling
  • Benign Breast Disease
  • Bile Leak
  • Breast
  • Breast - Nodules
  • Breast Cancer - High Risk
  • Breast Cancer - Mass, Lump or Swelling
  • Breast Disease
  • Breast Infections
  • Breast Lump
  • Breast Pain
  • Cancer - Prevention
  • Cancer Genomic Medicine
  • Dilated Breast Duct
  • Family Cancer History
  • Family History of Breast Cancer
  • Fibrocystic Breast Changes
  • Gynecomastia
  • Hereditary Cancer Risk Management
  • Hereditary Cancers
  • Lymphadenopathy
  • Lymphedema
  • Mastitis
  • Nipple Discharge
View all 33 Specialties +


Is Cleveland Clinic Part of Your Insurance?

Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan.

View All Plans

About Holly Pederson, MD

Holly Pederson, MD, is a Staff Physician and Director of Medical Breast Services in the Breast Center.  She is an Associate Professor at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

After receiving her BA in Biochemistry from the University of California-Santa Barbara where she received the distinction of Phi Beta Kappa, Dr. Pederson earned her medical degree from the University of California-San Francisco School of Medicine where she was recognized in the Alpha Omega Alpha honors society. She completed her internship and residency at the University of California San Francisco Medical Center in Internal Medicine, and in 2008 completed a clinical fellowship in Genomics at Cleveland Clinic.  She directs the Medical Breast Program and is active in clinical research.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Residency - University of California San Francisco Medical Center
Internal Medicine
San Francisco, CA USA

Internship - University of California San Francisco Medical Center
Internal Medicine
San Francisco, CA USA

Medical Education - University of California-San Francisco School of Medicine
San Francisco, CA USA

Undergraduate - University of California-Santa Barbara
Biochemistry/Molecular Biology
Santa Barbara, CA USA

Additional Training

  • Dr. Pederson has a special interest and subspecialty training in hereditary breast cancer.

Professional Highlights

  • Research and Publications: 

    1. Smedira Holly Jane, “Practical Issues in Counseling Healthy Women About Their Breast Cancer Risk and
    Use of Tamoxifen Citrate,” Arch Intern Med 2000;160:3034-3042
    2. Smedira, Patrick, Rybicki and Crowe, “Integrating Medical Breast Specialists into the Traditional Breast
    Center Practice Model: A Review of 11 Years of Experience” Arch Intern Med 2008; 168:2042-2045
    3. Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, Milas K, Pederson H, Remzi B, Orloff MS, Eng C. “A Clinical Scoring System for Selection of Patients For PTEN Mutation Testing is Proposed on the Basis
    Of a Prospective Study of 3042 Probands” The American Journal of Human Genetics  2011: 88, 1-15
    4. Pederson HJ, O'Rourke C, Lyons J, Patrick RJ, Crowe JP Jr, Grobmyer SR. "Time Related Changes in Yield and Harms of Screening Breast MRI" Clin Breast Cancer. 2015 Oct; 15(5): 348-352.  
    5. Pederson HJ, Padia S, May M, Grobmyer S, “Management of Patients at Genetic Risk for Breast Cancer”, Cleveland Clinic Journal of Medicine  2016.  83;(3): 199-206.
    6. McCray D,  Grobmyer S, Pederson H “Impact of Value Based Breast Cancer Care Pathway on Pre-Operative Breast MRI Utilization”  Gland Surgery 2017 Feb; 6(1): 57-63 
    7. Donaldson AR, McCarthy C, Goraya S, Pederson HJ, Sturgis CD, Grobmyer SR, Calhoun BC, “Breast Cancer Risk Associated with Atypical Hyperplasia and Lobular Carcinoma in Situ Initially Diagnosed on Core Needle Biopsy,” Cancer 2018 Feb 1; 124 (3): 459-465.
    8. Pederson HJ, Gopalakrishnan D, Noss R, Yanda C, Eng C, Grobmyer SR, “Impact of Multigene Panel Testing on Surgical Decision Making in Breast Cancer Patients,” . J Am Coll Surg. 2018 Apr, 226(4):560-565.
    9. Pederson HJ, “Breast Cancer Risk Assessment and Treatment:  Current Concepts in Genetics and Genomics,”  Contemporary OB/GYN December 2017.  
    10. Pederson HJ, Hussain N, Noss R, Yanda C, O’Rourke C, Eng C and Grobmyer SR “Impact of an embedded genetic counselor on breast cancer treatment,” Breast Cancer Res Treat. 2018 May;169 (1): 43-46.
    11. Pederson HJ “Who needs breast cancer genetics testing?” OBG Manag. 2018 June; 30;(6) 34-39
    12. Grobmyer SR, Pederson HJ, Valente SA, Al-Hilli A, Radford D, Djohan R, Yetman R, Eng C and Crowe J. “Evolving Indications and Long Term Oncologic Outcomes of Risk Reducing Bilateral Nipple Sparing Mastectomy” BJS Open . 2018 Nov 26;3(2): 169-173.
    13. Pederson HJ. “Clinical care of women with intermediate breast cancer risk” Menopause. 2019 Jul; 26(7): 797-799
    14. Modesitt S, Pederson HJ, Adkins RT. “Practical Cancer Genetics and Genomics in Women’s Health”. Clin Obstet Gynecol. 2019 Jul 11.


  • Internal Medicine

Specialty Interests

Family history of breast cancer and Breast cancer risk assessment and prevention, Breast diagnostics, Benign breast disease, Breast cancer genetics and High risk management, Hereditary cancer risk management

Innovations & Patents

  • Dr. Pederson helped to create the Medical Breast Program at Cleveland Clinic in 1997, and now offers a subspecialty  Hereditary High Risk Clinic for patients with identified genetic mutations predisposing to breast cancer, family members of mutation carriers or patients from families with a strong family history of breast cancer. 


  • American Society of Clinical Oncology
  • American Society of Breast Surgeons
  • Case Comprehensive Cancer Center - Cancer Genetics Program 
Research & Publications

Research & Publications

See publications for Holly Pederson, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 10/5/2020, Dr. Pederson has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

190 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.8

57 Patient Comments

Reviewed on Sep 23, 2020

I had a great experience with Dr. Pederson. She really cares and wants to follow my progress.

Reviewed on Sep 16, 2020

Dr.Holly Pederson is a thorough , compasionate person. She eased my mind and worked on a plan that would continue to keep me healthy. She needs to be CLONED!

Reviewed on Sep 15, 2020

Dr. Pederson is amazing!

Reviewed on Sep 12, 2020

Dr. Pederson even met with me on a Saturday because she knew I'd be visiting with my daughter in Cleveland on Friday after my appointment and I wasn't sure when I'd get home.

Reviewed on Sep 12, 2020

Dr. Pederson is awesome!

Reviewed on Sep 2, 2020

Dr. Pedeson was very knowledgable and answered my questions as well as addressed my concerns

Reviewed on Aug 26, 2020

Scheduling an appointment with Dr. Pederson was extremely easy and the appointment itself went extremely well!

Reviewed on Aug 26, 2020

Dr. Pederson was extremely caring and handled the appointment with care. She was able to answer all of my questions.

Reviewed on Aug 20, 2020

we discuss in detail my treatment, options and risks with my condition. I believe she saved my life by investigating further, and not just going by what the original test results showed. I have recommended Dr. Pederson to many women that I care about.

Reviewed on Aug 13, 2020

Excellent demeanor--a doctor, but also a real person. Perfect combo.

Reviewed on Aug 6, 2020

Access is limited due to high demand for the excellent Dr. Pederson

Reviewed on Aug 6, 2020

Dr. Pederson is an excellent clinician, very knowledgeable, and always addresses my concerns or questions. She is a fantastic provider, and I'll continue to choose to receive care from her as long as she is practicing.

Reviewed on Aug 6, 2020

Wish I didn't have to go to the main campus since I live in Akron. But I will travel anywhere to see Dr. Pederson!

Reviewed on Aug 5, 2020

Dr Pederson is always amazing.

Reviewed on Jul 24, 2020

Dr. Pederson and her staff are amazing. i am so grateful for her attentiveness to my care and approachability. She is really fantastic and I appreciate her knowledge and transparency.

Reviewed on Jul 24, 2020

my sister and I both see Dr.Pederson and we love her. She is a great physician and we feel reassured being high risk that she follows pur care so well.

Reviewed on Jul 22, 2020

I am very grateful for the compassionate care provided by Dr. Pederson. She always works with me to organize a clear plan for my long term preventative care. Dr. Pederson also takes the time to provide feedback regarding my test results and recommendations for my care moving forward. Thank you for providing excellent care.

Reviewed on Jul 22, 2020

I feel like my doctor is genuinely concerned about my wellbeing and my health

Reviewed on Jul 22, 2020

Dr. Pederson is the best. Even though she is a breast specialist, I always feel like she cares about me as a whole person.

Reviewed on Jun 25, 2020

Dr. Holly Pederson is very pleasant talking to me, explained my diagnosis very well and I understand everything what she said. Looking forward to my next appointment in March, 2021.

Reviewed on Jun 24, 2020

Dr. Pedersen is the best!

Reviewed on Jun 24, 2020

Dr. Pederson is amazing. So glad she is my doctor.

Reviewed on Jun 23, 2020

Dr Holly Pederson is always prompt, kind, and interested in what I have to say .

Reviewed on Jun 22, 2020

I loved Dr. Pederson. She was so informative and kind.

Reviewed on Jun 22, 2020

Waited over 45 minutes before Dr. Peterson arrived in examining room.

Reviewed on Jun 19, 2020

dr. holly pederson is an outstanding physician.

Reviewed on Jun 18, 2020

Dr. P is clear, kind, and reassuring. I appreciate how thorough and careful she is with my care, given that I have a genetic mutation.

Reviewed on Jun 17, 2020

followers dr Petersen from beachwood. she is awesome

Reviewed on May 27, 2020

office kept me informed with doctors schedule....which i appreciated

Reviewed on May 27, 2020

very pleased of the doctors asking of both my daughters appointments and the fact she will see them both and take things from the beginning for them.

Reviewed on May 27, 2020

Love Dr Keller

Reviewed on May 21, 2020

Glad I waited to see Dr Pederson very thorough and pleasant knowlegdeable

Reviewed on May 1, 2020

Dr. Pederson listened to my concerns and answered all questions thoroughly.

Reviewed on Apr 30, 2020

I was very impressed with Dr Pederson and her knowledge of my concerns.

Reviewed on Apr 1, 2020

Dr. Pederson is the best. She truly listens and cares about her patients and their well-being. She made sure all my concerns were addressed before I left the office that day.

Reviewed on Feb 26, 2020

Dr. Pederson takes the time to look at my healthcare wholistically and not just within her specialty. In fact, she noticed something in my family history and suggested a referral where a genetic diagnosis was discovered! She is also quick to reply to MyChart messages. I'm so grateful to have her on my healthcare team.

Reviewed on Feb 6, 2020

Dr. Pedersen was very kind and knowledgeable. enjoyed meeting her. Made me feel cared for and safe.

Reviewed on Feb 5, 2020

Dr Petersen is amazing. The staff at the desks are friendly and accommodating.

Reviewed on Feb 5, 2020

I love Dr Petersen. She tells me my risks. Is kind, thorough, and listens.

Reviewed on Feb 3, 2020

everyone was respectful and kind. dr Pederson was very thorough and explained everything in detail. it was my first appointment with her and she had reviewed my history in detail.

Reviewed on Jan 28, 2020

The office staff and Dr. Pederson are fantastic!

Reviewed on Jan 27, 2020

Dr Pederson treats me as if I were a member of her family. She listens, has patience and I feel at peace with her.

Reviewed on Jan 3, 2020

Waited in the room for the physician for 40 minutes. Once the physician entered the room, felt a little rushed to process the information and formulate questions to ask.

Reviewed on Dec 20, 2019

absolutely love my doctor.

Reviewed on Dec 20, 2019

Dr H. Pederson was very caring and answered all of my questions. Dr. H explained all my concerns I hadand had a great bedside manor. AWESOME!!!

Reviewed on Dec 12, 2019

Doctor was awesome.

Reviewed on Nov 27, 2019

Dr Pedersen is extremely competent, caring. Very impressed!

Reviewed on Nov 22, 2019

dr Pederson is my moms breast doctor. when I had an issue I was referred to her. she spent a lot of time with me, answered all of my questions and will continue to follow up with me. she is great!

Reviewed on Nov 19, 2019

Dr. Pederson is an excellent doctor! she always listens to me and helps with any questions or concerns. I fully trust her for my care and I?m so thankful to have her as my specialist!

Reviewed on Nov 4, 2019

Dr. Holly Pederson is the absolute best. She is so genuine and truly caring and a total expert in her field. I will miss having her as my doctor. She advised me at my last appointment that is transitioning into moving to Canada and will not be seeing patients much more after Jan 2020. She is a very rare find in a doctor.

Reviewed on Oct 30, 2019

Once Dr. Pederson arrived, everything went well. I was disappointed to learn she will be spending 6 months in Canada and she recommended I see a certified nurse practitioner in the Beachwood office next year.

Reviewed on Oct 30, 2019

I liked Dr. Pederson and am disappointed that I have to see someone else next year. I cannot recommend the new person until I have an appointment with her.

Reviewed on Oct 30, 2019

Dr. Pedersen is always super and an expert in her field - feel very fortunate to have access to a doc like her.

Reviewed on Oct 29, 2019

Dr. Pederson is an exceptional physician who demonstrates respect and empathy in every interaction. She is highly skilled and knowledgeable and she fully understands what it means to involve the patient in the decision making process.

Reviewed on Oct 29, 2019

dr. Peterson is wonderful and caring !!! but waiting 110 minutes is too long!!!

Reviewed on Oct 28, 2019

I liked Dr Peterson very much

Reviewed on Oct 21, 2019

Love Dr. Pederson! A pleasant and informative visit.

Related Videos Featuring Holly Pederson, MD

Related Videos Featuring Holly Pederson, MD

Back to Top