Department Pulmonary Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Specialty in Diseases & Conditions

  • Bronchiolitis Obliterans
  • Connective Tissue Diseases
  • Hypersensitivity Pneumonitis
  • Idiopathic Pulmonary Fibrosis
  • Interstitial Lung Disease (ILD)
  • Lung Dominant Connective Tissue Disease
  • Radiation Fibrosis - Lung
  • Rheumatic Lung Disease
  • Sarcoidosis
View all 9 Specialties +


Is Cleveland Clinic Part of Your Insurance?

Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan.

View All Plans

About Brian Southern, MD

Dr. Southern is a Staff Physician in the Respiratory Institute and Assistant Professor of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. He has a secondary appointment as an Associate Staff Scientist in the Lerner Research Institute Department of Pathobiology, where his research focus is Idiopathic Pulmonary Fibrosis (IPF). Dr. Southern explores how fibroblasts and myofibroblasts (the scar-producing cells in IPF) interact with lung tissue matrix to propagate fibrosis. He has identified that the molecular motor protein, non-muscle myosin II, is a critical molecule driving fibrosis, and is further characterizing the myosin II pathway in fibroblasts in order to identify novel targets to halt fibrosis in patients with IPF.

In addition to his research activities, Dr. Southern conducts an outpatient clinic where he cares for patients with interstitial lung disease and sarcoidosis, and he is a co-investigator on a number of clinical trials for patients with IPF. He serves as the physician leader for the Cleveland area Pulmonary Fibrosis Support Group. He is also very active in social media (Facebook:; Twitter: @TodayIPF) where he provides the latest research, treatment options, and news for patients with IPF and their families.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Case Western Reserve University - University Hospitals of Cleveland
Pulmonary & Critical Care Medicine
Cleveland, OH USA

Residency - Case Western Reserve University - University Hospitals of Cleveland
Internal Medicine
Cleveland, OH USA

Medical Education - University of Alabama School of Medicine
Birmingham, AL USA

Undergraduate - University of Alabama at Birmingham
Birmingham, AL USA

Professional Highlights

  • Dr. Southern has been invited to present his research findings at local and national meetings, including the American Thoracic Society International Conference, the Keystone Symposium on Fibrosis,and the Society for Clinical Research/Midwestern Section American Federation for Medical Research (CSCR/MWAFMR).  He has been awarded research funding from the National Institutes of Health (NIH), the Parker B Francis Foundation, Genentech, Inc., and the Cleveland Clinic Research Program Committee.  He has served as a grant reviewer for the Department of Defense Congressionally Directed Medical Research Programs (CDMRP), the Foundation for Sarcoidosis Research, and the Cleveland Clinic Research Program Committee. He reviews manuscripts for a number of scientific journals. He also supervises pulmonary fellows in the Interstitial Lung Disease Clinic and on the inpatient pulmonary consult service. Additionally, he serves as a volunteer physician at the Free Medical Clinic of Greater Cleveland. 


  • Internal Medicine
  • Internal Medicine - Pulmonary Disease
  • Internal Medicine - Critical Care Medicine

Specialty Interests

Idiopathic Pulmonary Fibrosis, Interstitial Lung Diseases, Sarcoidosis

Awards & Honors

  • 2017 NIH K08 Award
  • 2017 Parker B Francis Fellowship Award (declined)
  • 2017 Parker B Francis Research Opportunity Award
  • 2015 Pulmonary Fibrosis Foundation Summit, Top Ten Abstract
  • 2015 Genentech Idiopathic Pulmonary Fibrosis Junior Faculty Award
  • 2014 Cleveland Clinic Research Program Committees Award
  • 2012 Travel Award, ATS Assembly on Respiratory Cell and Molecular Biology
  • 2009 The Peter Morgan Award, for outstanding leadership as a senior resident


  • American Thoracic Society
  • American Society for Matrix Biology
  • American Association for the Advancement of Science
Research & Publications

Research & Publications

See publications for Brian Southern, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 1/23/2019, Dr. Southern has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

77 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
5 out of 5
Explains 5
Listens 5
Courtesy, Respect & Concern 5
Knows Medical History 5
Time Spent with Patient 5
Patient Rating of Doctor 5

23 Patient Comments

Reviewed on Jul 26, 2019

I was VERY PLEASED by the way Doctor Southern and his assistants conducted the appointment and the real interest he took in my medical situation. This was very Positive and encouraging experience for me.

Reviewed on Jul 19, 2019

wonderful doctor

Reviewed on Jul 11, 2019

Dr. Southern is a wonderful doctor. Brilliant, caring and kind. we are so grateful to him.

Reviewed on Jun 28, 2019

Dr. Southern thoroughly explained my condition and answered all of my questions patiently.

Reviewed on May 31, 2019

Dr. Southern and staff could not have been more attentive to my current and future health needs moving forward.

Reviewed on May 31, 2019

very impressed with Dr. Southern, very kind, takes his time and very informative.

Reviewed on May 24, 2019

Dr Southern is a very good doctor the best

Reviewed on May 24, 2019

took over an hour to see doctor

Reviewed on May 24, 2019

Dr. Southern was amazing with getting back to me very quickly. He also set my appointment to see him and have my testing done all on the same day. I got my results very quickly. I could not have had better care. He is a great Doctor.

Reviewed on Apr 26, 2019

very good experience. I found Dr. Southern and his staff to be experts in their field and because of this I believe the Cleveland Clinic is the best place for me to receive my care.

Reviewed on Apr 26, 2019

I can not say enough good things about Dr. Southern, he listens, is compassionate and knowledgeable about my situation.

Reviewed on Feb 22, 2019

Dr Southern is always very kind!

Reviewed on Jan 25, 2019

Dr. Southern is courteous. He listens well and spends ample time to discuss all concerns.

Reviewed on Jan 18, 2019

Excellent. Physician was obviously a leader in his field, but was also willing to accept and follow up on an article that I had found that he also saw value in. Many physicians would not accept suggestions like this from patients, especially new patients.

Reviewed on Jan 18, 2019

Dr. Southern is a very caring and thoughtful physician. He really listens to his patients. He has been able to diagnose and treat my conditions when no other physicians could. I am very grateful for his expertise! He's a wonderful physician !!

Reviewed on Jan 4, 2019

The Dr. went over everything in detail and explained everything in a way I could understand what he was talking about. He made me feel like I was the only patient he had.

Reviewed on Dec 7, 2018

he speaks to me as if he encourages my input. This man is a superior doctor with knowledge ,skills and a manner which shows his superiority. God bless him!

Reviewed on Nov 2, 2018

Dr Sourthern couldn't have been better. Ihad just been diagnosed with a fatal disease,believe it or not despite there being no cure ,I felt much better talking to this knowledgeable & kind man.

Reviewed on Nov 2, 2018

talked with doctor

Reviewed on Oct 26, 2018

Doctor Southern goes above and beyond for my mother.. this makes things much more reassuring for her and my family to have her in his care. He is kind, compassionate, and extremely intelligent, and answers questions promptly. I would highly recommend him!

Reviewed on Oct 19, 2018

Dr. Southern is great. He quickly puts his patients at ease, and they quickly come to trust him. He is patient and listens carefully. He is knowledgeable and resourceful.

Reviewed on Oct 5, 2018

Dr. Southern was great! He was very thorough and listened intently as I expected xpressed my concerns. He found problems other doctors had missed. I feel fortunate to have the benefit of his expertise. I left his office feeling hopeful and confident in my care for the first time in a long time.

Reviewed on Sep 14, 2018

felt very comfortable talking to doctor

Related Videos Featuring Brian Southern, MD

Related Videos Featuring Brian Southern, MD

Back to Top