Department Pulmonary Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Specialty in Diseases & Conditions

  • Bronchiolitis Obliterans
  • Connective Tissue Diseases
  • Hypersensitivity Pneumonitis
  • Idiopathic Pulmonary Fibrosis
  • Interstitial Lung Disease (ILD)
  • Lung Dominant Connective Tissue Disease
  • Radiation Fibrosis - Lung
  • Rheumatic Lung Disease
  • Sarcoidosis
View all 9 Specialties +


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About Brian Southern, MD

Dr. Southern is a Staff Physician in the Respiratory Institute and Assistant Professor of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. He has a secondary appointment as an Associate Staff Scientist in the Lerner Research Institute Department of Pathobiology, where his research focus is Idiopathic Pulmonary Fibrosis (IPF). Dr. Southern explores how fibroblasts and myofibroblasts (the scar-producing cells in IPF) interact with lung tissue matrix to propagate fibrosis. He has identified that the molecular motor protein, non-muscle myosin II, is a critical molecule driving fibrosis, and is further characterizing the myosin II pathway in fibroblasts in order to identify novel targets to halt fibrosis in patients with IPF.

In addition to his research activities, Dr. Southern conducts an outpatient clinic where he cares for patients with interstitial lung disease and sarcoidosis, and he is a co-investigator on a number of clinical trials for patients with IPF. He serves as the physician leader for the Cleveland area Pulmonary Fibrosis Support Group. He is also very active in social media (Facebook:; Twitter: @TodayIPF) where he provides the latest research, treatment options, and news for patients with IPF and their families.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Case Western Reserve University - University Hospitals of Cleveland
Pulmonary & Critical Care Medicine
Cleveland, OH USA

Residency - Case Western Reserve University - University Hospitals of Cleveland
Internal Medicine
Cleveland, OH USA

Medical Education - University of Alabama School of Medicine
Birmingham, AL USA

Undergraduate - University of Alabama at Birmingham
Birmingham, AL USA

Professional Highlights

  • Dr. Southern has been invited to present his research findings at local and national meetings, including the American Thoracic Society International Conference, the Keystone Symposium on Fibrosis,and the Society for Clinical Research/Midwestern Section American Federation for Medical Research (CSCR/MWAFMR).  He has been awarded research funding from the National Institutes of Health (NIH), the Parker B Francis Foundation, Genentech, Inc., and the Cleveland Clinic Research Program Committee.  He has served as a grant reviewer for the Department of Defense Congressionally Directed Medical Research Programs (CDMRP), the Foundation for Sarcoidosis Research, and the Cleveland Clinic Research Program Committee. He reviews manuscripts for a number of scientific journals. He also supervises pulmonary fellows in the Interstitial Lung Disease Clinic and on the inpatient pulmonary consult service. Additionally, he serves as a volunteer physician at the Free Medical Clinic of Greater Cleveland. 


  • Internal Medicine - Pulmonary Disease
  • Internal Medicine - Critical Care Medicine

Specialty Interests

Idiopathic Pulmonary Fibrosis, Interstitial Lung Diseases, Sarcoidosis

Awards & Honors

  • 2017 NIH K08 Award
  • 2017 Parker B Francis Fellowship Award (declined)
  • 2017 Parker B Francis Research Opportunity Award
  • 2015 Pulmonary Fibrosis Foundation Summit, Top Ten Abstract
  • 2015 Genentech Idiopathic Pulmonary Fibrosis Junior Faculty Award
  • 2014 Cleveland Clinic Research Program Committees Award
  • 2012 Travel Award, ATS Assembly on Respiratory Cell and Molecular Biology
  • 2009 The Peter Morgan Award, for outstanding leadership as a senior resident


  • American Thoracic Society
  • American Society for Matrix Biology
  • American Association for the Advancement of Science
Research & Publications

Research & Publications

See publications for Brian Southern, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 2/24/2020, Dr. Southern has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

67 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
5 out of 5
Explains 5
Courtesy, Respect & Concern 5
Patient Rating of Doctor 5

32 Patient Comments

Reviewed on Aug 7, 2020

I thought very highly of the staff and Dr. Southern. My doctor down here has never had a case of what I had and did not want to give me any details, so I worried about it all from February. Dr. Southern answered all questions and was very informative. He took his time with me. I am very appreciative.

Reviewed on Jun 19, 2020

The scheduler was very respectful of my need to see Dr. Southern and got me in, in a timely manner.

Reviewed on Jun 19, 2020

Dr. Southern showed extreme empathy for my problem. I thought he went above and beyond in trying to figure out my problem and a way to correct it.

Reviewed on May 22, 2020

Dr. Southern was very concerned about my symptoms and he listened to my concerns about them before he made a decision about a course of care.

Reviewed on May 15, 2020

Dr Brian is an awesome doc

Reviewed on May 15, 2020

love Brian Southern such an awesome doctor

Reviewed on Mar 20, 2020

Great Doctor / Great Person Very Blessed to have Doctor Southern treating me

Reviewed on Feb 27, 2020

Dr. Southern is absolutely wonderful. I feel I'm well cared for because he's watching over things. He does a great job explaining things-pathophysiology, to medications.

Reviewed on Feb 27, 2020

Dr Southern is a good soul & I'm so very grateful he's one of my doctors. I have complete faith in him.

Reviewed on Feb 26, 2020

Dr Southern is a top notch doctor in every respect

Reviewed on Feb 14, 2020

the whole visit was efficient with all care givers and Dr. Southern doing a great job.

Reviewed on Feb 7, 2020

Care provider was very easy to understand and took the time needed for all my questions. I really felt good about having him help with my care.

Reviewed on Feb 7, 2020

I had a very good experience with Dr. Southern. As usual he was caring and straight forward with me on my medical situation.

Reviewed on Feb 7, 2020

Dr. Southern was an excellent doctor. I wish the world had more like him who really cared.

Reviewed on Jan 28, 2020

Dr. Southern is AMAZING! He is very attentive to problems and concerns. He never appears rushed and truly cares about his patients which is why we drive over an hour to see him.

Reviewed on Jan 17, 2020

Dr. Littlejohn is where my issues lie. I am compiling a further communication to discuss her poor bedside manner.

Reviewed on Jan 10, 2020

Doc Southern is all round excellent

Reviewed on Jan 10, 2020

Dr Southern was awesome, he spent a great deal of time with us talking with us and explaining things

Reviewed on Jan 10, 2020

Dr Southern was very good talking about my issues and treatment

Reviewed on Dec 30, 2019

He has been the best provider I've seen at Cleveland Clinic & I'm so grateful for his care.

Reviewed on Dec 30, 2019

Very thorough, comprehensive visit with Dr. Southern.

Reviewed on Dec 20, 2019

dr southern is a very very caring and conscientious man who is always there for us when we have questions and concerns! he is awesome!!

Reviewed on Dec 20, 2019

dr southern is very very easy to talk with and truly cares for his patients!

Reviewed on Dec 20, 2019

dr southern reached out to our neurologist during our visit to ensure we had a very complete visit!! we were so happy and satisfied with his efforts!

Reviewed on Nov 27, 2019

Dr. Southern was very kind and explained the condition as well as how we were going to treat it. I am so glad we found him.

Reviewed on Nov 7, 2019

Dr. Southern and everyone there are the best.

Reviewed on Nov 7, 2019

I have been pleased with Dr Southern's care and concern

Reviewed on Nov 7, 2019

Dr Southern is a top notch professional I have the utmost respect for Dr Southern and his abilities and feel like my care is in the best place it can be

Reviewed on Oct 18, 2019

love Dr Brian and the lady who registered me

Reviewed on Sep 27, 2019

Dr. Southern's staff was very efficient in the procedures and the Dr. was very informative, thorough and personable.

Reviewed on Sep 20, 2019

Very thorough appointment. Met with Doctor Southern for well over an hour.

Reviewed on Sep 20, 2019

He is excellent in every professional way! This man is a superb doctor who is professional.friendly and who explains everything he is very well taught and trained.

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