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Department Pulmonary Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Specialty in Diseases & Conditions

  • Bronchiolitis Obliterans
  • Connective Tissue Diseases
  • Hypersensitivity Pneumonitis
  • Idiopathic Pulmonary Fibrosis
  • Interstitial Lung Disease (ILD)
  • Lung Dominant Connective Tissue Disease
  • Radiation Fibrosis - Lung
  • Rheumatic Lung Disease
  • Sarcoidosis
View all 9 Specialties +


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About Brian Southern, MD

Dr. Southern is a Staff Physician in the Respiratory Institute and Assistant Professor of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. He has a secondary appointment as an Associate Staff Scientist in the Lerner Research Institute Department of Pathobiology, where his research focus is Idiopathic Pulmonary Fibrosis (IPF). Dr. Southern explores how fibroblasts and myofibroblasts (the scar-producing cells in IPF) interact with lung tissue matrix to propagate fibrosis. He has identified that the molecular motor protein, non-muscle myosin II, is a critical molecule driving fibrosis, and is further characterizing the myosin II pathway in fibroblasts in order to identify novel targets to halt fibrosis in patients with IPF.

In addition to his research activities, Dr. Southern conducts an outpatient clinic where he cares for patients with interstitial lung disease and sarcoidosis, and he is a co-investigator on a number of clinical trials for patients with IPF. He serves as the physician leader for the Cleveland area Pulmonary Fibrosis Support Group. He is also very active in social media (Facebook:; Twitter: @TodayIPF) where he provides the latest research, treatment options, and news for patients with IPF and their families.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Case Western Reserve University - University Hospitals of Cleveland
Pulmonary & Critical Care Medicine
Cleveland, OH USA

Residency - Case Western Reserve University - University Hospitals of Cleveland
Internal Medicine
Cleveland, OH USA

Medical Education - University of Alabama School of Medicine
Birmingham, AL USA

Undergraduate - University of Alabama at Birmingham
Birmingham, AL USA

Professional Highlights

  • Dr. Southern has been invited to present his research findings at local and national meetings, including the American Thoracic Society International Conference, the Keystone Symposium on Fibrosis,and the Society for Clinical Research/Midwestern Section American Federation for Medical Research (CSCR/MWAFMR).  He has been awarded research funding from the National Institutes of Health (NIH), the Parker B Francis Foundation, Genentech, Inc., and the Cleveland Clinic Research Program Committee.  He has served as a grant reviewer for the Department of Defense Congressionally Directed Medical Research Programs (CDMRP), the Foundation for Sarcoidosis Research, and the Cleveland Clinic Research Program Committee. He reviews manuscripts for a number of scientific journals. He also supervises pulmonary fellows in the Interstitial Lung Disease Clinic and on the inpatient pulmonary consult service. Additionally, he serves as a volunteer physician at the Free Medical Clinic of Greater Cleveland. 


  • Internal Medicine - Pulmonary Disease
  • Internal Medicine - Critical Care Medicine

Specialty Interests

Idiopathic Pulmonary Fibrosis, Interstitial Lung Diseases, Sarcoidosis

Awards & Honors

  • 2017 NIH K08 Award
  • 2017 Parker B Francis Fellowship Award (declined)
  • 2017 Parker B Francis Research Opportunity Award
  • 2015 Pulmonary Fibrosis Foundation Summit, Top Ten Abstract
  • 2015 Genentech Idiopathic Pulmonary Fibrosis Junior Faculty Award
  • 2014 Cleveland Clinic Research Program Committees Award
  • 2012 Travel Award, ATS Assembly on Respiratory Cell and Molecular Biology
  • 2009 The Peter Morgan Award, for outstanding leadership as a senior resident


  • American Thoracic Society
  • American Society for Matrix Biology
  • American Association for the Advancement of Science
Research & Publications

Research & Publications

See publications for Brian Southern, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 2/18/2021, Dr. Southern has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

76 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
5 out of 5
Explains 5
Courtesy, Respect & Concern 5
Patient Rating of Doctor 5

21 Patient Comments

Reviewed on Oct 8, 2021

Dr Southern is knowledgeable yet humble and he always allows me to assist in my treatment. He is an excellent Doctor!!

Reviewed on Sep 24, 2021

I felt valued as a patient by Dr Southern returning after leaving for the day.

Reviewed on Sep 10, 2021

Dr. Southern was wonderful! He had no problem with me doing FaceTime with my son during the consultation. We liked the way he explained the progression of Sjorgren's in my lungs while showing us the CT. He spent a great deal of time with us and answered our questions.

Reviewed on Jul 30, 2021

Dr Southern and his staff are excellant

Reviewed on Jul 9, 2021

Dr. Southern shared his expertise in a way I wish all medical providers did. He obviously cared about me and my health. He was kind, efficient and demonstrated a depth of unique knowledge that was so helpful. I appreciate his detail oriented description of my past and current disease state. Personally showing me and my wife several CT scans of my lungs and describing what we were seeing in each scan. He described in detail the mechanism of the disease process at the most refined level so we could understand the mechanics of things that are occurring and creating problems. Thank you so much for this.

Reviewed on May 7, 2021

there is not a physician better than Dr. Brian Southern. He shows the utmost care and compassion, never makes you feel rushed, and is meticulous in the care he provides. I live an hour away and traveling that distance is ever a burden because of the outstanding care he provides.

Reviewed on Apr 30, 2021

Dr Southern put.myind at ease and answered all my questions to my satisfaction

Reviewed on Apr 23, 2021

Dr Southern is so knowledgeable, caring, and he really takes his time answering questions and explaining things. He saved my life 3 years ago when I had been misdiagnosed by 2 other institutions. I thank God every day for putting him in my path.

Reviewed on Apr 16, 2021

Dr. Southern was fantastic with a great bedside manner.

Reviewed on Apr 16, 2021

My husband and I have, and continue, to recommend Dr. Southern for his sincere concern for my well-being, his knowledge and in how his confidence helps us feel my health plan is headed in the right direction.

Reviewed on Apr 9, 2021

love dr Brian treats me like family

Reviewed on Apr 2, 2021

Love Dr. Southern very kind and respectful. Great Dr.

Reviewed on Mar 26, 2021

Dr. Southern has always been an amazingly caring provider. My concerns have always been addressed. I have always felt understood and that is rare in the medical world. The single reason I come to the Cleveland Clinic.

Reviewed on Mar 5, 2021

Dr Southern is and has always been the type of doctor one wishes for all their medical needs. He not only addresses my medical condition but explain the PFT test results in a way I can understand them. He talks TO me not at me and shares my concerns. His medication recommendations have been very helpful. Great experience with him and always look forward to my visits.

Reviewed on Mar 5, 2021

Dr. Southern has been comprehensive with the treatment options available and he has been extremely attentive to my circumstances.

Reviewed on Feb 26, 2021

I think Dr Southern is that amazing doctor. He was very compassionate and listen very well. I am very happy he is taking care of me.

Reviewed on Feb 26, 2021

Dr Southern and his staff are first rate

Reviewed on Jan 15, 2021

Excellent personal attention by all particularly Dr. southern

Reviewed on Dec 4, 2020

I felt like I was very informed by the doctor.

Reviewed on Nov 27, 2020

Dr. Brian Southern was assigned to me as a patient of Cleveland Clinic and I have been so fortunate in that act. Dr. Southern has made communicating with him so easy. He has always responded to my questions quickly.

Reviewed on Nov 27, 2020

Dr. Southern is a blessing to me and my family. His knowledge of my lung disease and care he shows me is unmatched to other doctors I have dealt with. I am grateful to Dr. Southern for his knowledge and compassion.

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