Locations:

TNF (Tumor Necrosis Factor) Inhibitors

TNF (tumor necrosis factor) inhibitors are medications that suppress inflammation within your immune system. They treat rheumatic diseases like inflammatory arthritis and inflammatory bowel disease.

What Are TNF Inhibitors?

TNF inhibitors (anti-TNF) are medications that treat autoinflammatory and autoimmune diseases. These drugs inhibit — block the action of — a type of protein in your body called tumor necrosis factor (TNF) alpha. TNF alphas play an important role in generating chronic inflammation in certain immune system disorders. TNF alpha inhibitors work to stop the process that produces the inflammation.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

What conditions can TNF inhibitors treat?

The U.S. Food and Drug Administration (FDA) has approved the use of TNF alpha inhibitors to treat:

Inflammatory arthritis

Inflammatory skin conditions

Inflammatory bowel disease

Eye inflammation

Healthcare providers may also prescribe anti-TNF treatment to treat other conditions when they believe it might be helpful. This is called off-label drug use. Some of the off-label uses of TNF blockers include:

Which drugs are TNF inhibitors?

TNF inhibitors currently approved by the U.S. Food and Drug Administration (FDA) include:

The FDA has also recently approved several biosimilar drugs for infliximab (Remicade) and adalimumab (Humira). These are similar alternatives that mimic the original drug (like generics for biologic drugs).

Biosimilars for infliximab (Remicade) include:

  • Inflectra® (infliximab-dyyb)
  • Renflexis® (infliximab-abda)
  • Avsola® (infliximab-axxq)

Biosimilars for adalimumab (Humira®) include:

Advertisement

  • Amjevita® (adalimumab-atto)
  • Cyltezo® (adalimumab-adbm)
  • Hyrimoz® (adalimumab-adaz)
  • Hadlima® (adalimumab-bwwd)
  • Abrilada® (adalimumab-afzb)
  • Hulio® (adalimumab-fkjp)
  • Yusimry® (adalimumab-aqvh)
  • Idacio® (adalimumab-aacf)
  • Yuflyma® (adalimumab-aaty)
  • Simlandi® (adalimumab-ryvk)

Biosimilars for other TNF inhibitors are also in progress.

What type of drug is an anti-TNF?

TNF inhibitors are biologic DMARDs (disease-modifying anti-rheumatic drugs). DMARDs treat rheumatic diseases by reducing chronic inflammation in your tissues. Biologics are medications derived from biological organisms. Biologic DMARDs are a relatively new class of drugs. They’re more effective than traditional DMARDs, but also more difficult — and therefore more expensive — to produce.

Anti-TNF biosimilars are also biologics. They’re just slightly different formulas. Biologics, by nature, can’t be reproduced exactly. But biosimilars are produced in a similar way, and they’re not significantly different. They’re equally effective and often less expensive to produce. This may, in theory, translate into consumer savings. However, many factors affect drug pricing and what consumers pay for drugs.

How do TNF blockers work?

TNF is a type of cytokine, a protein that acts as a chemical messenger in your immune system. When TNF binds to receptors on your cells, it sends a signal to activate inflammatory processes. There are two types of TNF: alpha and beta. Both types of TNF are involved in inflammation, but anti-TNF therapy targets TNF alpha, specifically. It blocks TNF alpha from binding to its receptors.

How do you take a TNF inhibitor?

Tumor necrosis factor (TNF) inhibitors are injection medications. They need to go straight to your bloodstream to work. Many people take TNF inhibitors by self-injection. A small needle delivers a small dose just under your skin. You may take it weekly, biweekly or monthly. Or you may take your TNF blocker by IV (through a vein) at your healthcare provider’s office. You’ll sit for an infusion every month or two.

Risks / Benefits

What are the advantages of tumor necrosis factor inhibitors?

TNF inhibitors have revolutionized the treatment of rheumatic diseases by effectively stopping inflammation before it starts. They’re especially helpful when these diseases cause different kinds of inflammatory symptoms in different parts of your body. They’re safe for long-term use, even when pregnant or breastfeeding. There are also some side benefits to using them long-term, including:

  • Reduced severity of COVID-19 infection
  • Reduced rate of osteoporosis from inflammatory arthritis
  • Reduced risk of cardiovascular disease and heart attack

What are the disadvantages of tumor necrosis factor alpha inhibitors?

TNF alpha inhibitors don’t always work for everyone. Some people’s immune systems reject the treatment, creating antibodies that target and remove it. This can also happen after many years of use, making the treatment less effective or ineffective over time. When they do work, TNF alpha inhibitors suppress your immune system. This weakens your defenses against infectious diseases.

Advertisement

Other potential side effects include:

  • Skin reactions at the injection site
  • Rare allergic reactions

Recovery and Outlook

What can I expect after starting treatment with a TNF inhibitor?

Most people say their symptoms start to improve after the first few doses. Some people need a few months of treatment before they can tell their TNF blocker is working. And for a few people, it might not ever work. If this happens to you, your healthcare provider might suggest a different TNF inhibitor. Or they might suggest a different type of biologic DMARD — one that targets a different type of cytokine.

Will I always need to take TNF inhibitors?

Most of the conditions TNF inhibitors treat are lifelong. So, you’ll need some form of medical care for life, whether that means medication or simply monitoring. In the past, stopping treatment wouldn’t have been a realistic goal. But if your symptoms disappear completely, after several years, you may be able to start tapering off your TNF inhibitor. Your provider will monitor what happens when you do.

A note from Cleveland Clinic

TNF alpha inhibitors have made a real difference for people living with rheumatic diseases. Today, these medications are often the first line of treatment your rheumatologist will suggest. For some people, they work so well that symptoms seem to disappear. But no treatment is a silver bullet for everyone. If they aren’t the answer for you, your provider will offer another option.

Advertisement

Medically Reviewed

Last reviewed on 07/02/2025.

Learn more about the Health Library and our editorial process.

Ad
Appointments 216.444.2606