Pyoderma Gangrenosum

Pyoderma gangrenosum is a skin condition linked to certain autoimmune diseases or an earlier skin injury. Medical experts aren’t sure of its causes, and it’s difficult to diagnose because it looks like other diseases. Medications and other treatment options can relieve your symptoms. Pyoderma gangrenosum may result in scarring.


What is pyoderma gangrenosum?

Pyoderma gangrenosum (pie-oh-der-muh gang-rah-no-sum) is a chronic, recurrent skin disorder in which small, discolored bumps or blisters (bullae) appear on your skin that can rapidly grow and join together to become large open sores (ulcers).

The number of ulcers can vary. Mild cases of pyoderma gangrenosum may only have one ulcer, while severe cases may have multiple or many. These ulcers can be painful.

There’s often a link between pyoderma gangrenosum and other systemic diseases.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Who does pyoderma gangrenosum affect?

Pyoderma gangrenosum affects people of all ages, though it’s rare in children. It most commonly affects women between the ages of 20 and 50. You may be more likely to develop pyoderma gangrenosum if you have:

How common is pyoderma gangrenosum?

Pyoderma gangrenosum isn’t common. Approximately 1 in every 100,000 people in the United States has pyoderma gangrenosum.


How does pyoderma gangrenosum affect my body?

Pyoderma gangrenosum causes small, discolored bumps and inflammation on your skin. The bumps may be anywhere on your body, but they commonly appear on your lower extremities (legs, ankles and feet).

The bumps often rapidly open up (erode) your skin and expand to large, painful ulcers.

Is pyoderma gangrenosum life-threatening?

Studies show that up to 70% of people with pyoderma gangrenosum often have more than one illness or disease occurring at the same time (comorbidities). A combination of pyoderma gangrenosum and other systemic diseases — including rheumatoid arthritis, inflammatory bowel disease and blood disorders — may increase the likelihood of death by 30%.


Is pyoderma gangrenosum an autoimmune disease?

Pyoderma gangrenosum may be an autoimmune disease. That means that pyoderma gangrenosum results from your immune system damaging tissue in your own body. For some people, pyoderma gangrenosum will improve after treatment for their other systemic diseases.

Symptoms and Causes

What are the symptoms of pyoderma gangrenosum?

Pyoderma gangrenosum commonly affects your lower extremities. It may also appear on your arms, genitals and neck.

Symptoms of pyoderma gangrenosum include:

  • Small, discolored (red, purple, blue, brown or black), pus-filled blisters that enlarge quickly.
  • Open ulcers with distinct, raised borders.
  • Inflammation and pain around your sores.
  • Fever.
  • Joint pain.

Your ulcers may be large and deep, and they can be very painful.

What causes pyoderma gangrenosum?

Medical experts don’t know exactly what causes pyoderma gangrenosum. More than half of people with pyoderma gangrenosum have other conditions, including rheumatoid arthritis, leukemia, lymphoma, ulcerative colitis and Crohn’s disease.

In addition, pyoderma gangrenosum often develops after an injury to your skin (pathergy), like trauma or surgery. Sometimes, pyoderma gangrenosum appears near a surgical opening (stoma site). This is peristomal pyoderma gangrenosum.

Is pyoderma gangrenosum contagious?

Pyoderma gangrenosum isn’t contagious. You can’t spread pyoderma gangrenosum to another person through skin-to-skin contact.

Diagnosis and Tests

How is pyoderma gangrenosum diagnosed?

Pyoderma gangrenosum can be challenging to diagnose. No single test can confirm a diagnosis, so healthcare providers often order tests to rule out other possible causes of skin problems. These diseases include:

These tests may include:

Management and Treatment

How do you get rid of pyoderma gangrenosum?

There are many possible treatment options for pyoderma gangrenosum.

In mild cases, your healthcare provider may prescribe topical creams or ointments that you apply to your ulcers.

In more severe cases, your healthcare provider may prescribe oral medications that you take by mouth with water. Some studies indicate that newer, more targeted medications (biologic agents) may also help.

Surgically removing (debriding) dead tissue from your ulcers may be helpful in some cases. But it has risks, as injury to your skin can potentially make your pyoderma gangrenosum symptoms worse (pathergy).

Early diagnosis and treatment are important in preventing scars.

What medications or treatments are used to treat pyoderma gangrenosum?

For early or mild cases of pyoderma gangrenosum, your healthcare provider may recommend:

For more severe cases of pyoderma gangrenosum, your healthcare may prescribe the following medications or treatments:

  • Immunosuppressant medications: These medications reduce your immune system’s ability to actively harm your own body. Examples include mycophenolate and cyclosporine.
  • Biologic agents: These medications target specific inflammatory proteins. Examples include infliximab, adalimumab and ustekinumab.
  • Hyperbaric oxygen therapy: This therapy treats wounds and other medical conditions by supplying you with 100% oxygen inside a special chamber. It allows you to absorb greater amounts of oxygen as you breathe, which helps your body tissues heal.
  • Skin graft: Skin grafting is a type of surgery. During this procedure, your healthcare provider takes healthy skin from one part of your body and transplants (moves) it to cover damaged skin on another part of your body.

How do I take care of myself if I have pyoderma gangrenosum?

Trauma, including cuts, punctures and scrapes, can worsen your symptoms. Be careful to avoid any trauma that can cause more ulcers.

It’s also important to keep your wounds clean to prevent infection. Carefully wash your wounds with clean running water and soap. Then, carefully cover it with a nonadhesive bandage to prevent dirt or bacteria from entering the site. Ideally, your dermatologist will give you more in-depth instructions concerning how to keep your pyoderma gangrenosum clean and dressed.

If you have a prescribed topical medication, wash your wound with clean running water and soap. Apply the medication to your wound, and then cover it with a nonadhesive bandage.

For more severe ulcers, your healthcare provider may recommend covering them in a hydrocolloid bandage (dressing). These bandages protect your ulcers from further irritation or infection. After two to three days, they’ll “melt” into your skin.

How long does it take pyoderma gangrenosum to heal?

Pyoderma gangrenosum is difficult to treat. Even with proper treatment, it may take weeks or even months to heal.


How can I prevent pyoderma gangrenosum?

Medical experts aren’t sure exactly what causes pyoderma gangrenosum, so there may be no way to prevent it.

Pyoderma gangrenosum can advance quickly and leave permanent scars. If you have any risk factors associated with pyoderma gangrenosum, such as leukemia or inflammatory bowel disease, be sure to let your healthcare provider know right away if you develop any skin problems. Ask your healthcare provider to refer a dermatologist or another specialist with experience in treating pyoderma gangrenosum.

Outlook / Prognosis

What can I expect if I have pyoderma gangrenosum?

Pyoderma gangrenosum is difficult to diagnose, so it’s important to have realistic expectations. You may need to see several specialists and undergo many tests to rule out other conditions. This may delay proper treatment.

You may feel overwhelmed, stressed or depressed as you and your healthcare provider work to diagnose pyoderma gangrenosum and develop a treatment plan. Ask your healthcare provider for any tips or suggestions on keeping yourself as comfortable as possible during this time.

After a pyoderma gangrenosum diagnosis, it may take up to several months to heal. You may wish to seek out pyoderma gangrenosum support groups. They allow you to share your experiences and learn new ways to manage your symptoms.

The outlook for people with pyoderma gangrenosum depends on the severity. Severe forms of pyoderma gangrenosum, along with the presence of comorbidities, can result in severe pain, scarring and death.

If you have pyoderma gangrenosum, it’s important to discuss your diagnosis with any healthcare provider who’s considering a procedure that may damage your skin, such as surgery. They must consider if the procedure’s benefits outweigh the risks of triggering pyoderma gangrenosum. If you must have the procedure, they’ll need to closely supervise you to prevent any new ulcers from developing.

Living With

When should I see my healthcare provider?

Contact your healthcare provider if:

  • You have inflammatory bowel disease, arthritis or a blood disorder and you start developing blisters or ulcers that grow quickly.
  • Your wounds look infected (red, purple, gray or white skin; irritation or swelling).
  • You develop new symptoms.
  • You develop severe side effects after taking medications.

What questions should I ask my healthcare provider?

  • How can you tell that I have pyoderma gangrenosum?
  • If I don’t have pyoderma gangrenosum, what other skin condition might I have?
  • What tests will you conduct?
  • What medications or treatments do you recommend?
  • Is there a cream or medication that you can prescribe?
  • What’s the complete list of side effects for the medications and treatments?
  • What else should I do to improve my symptoms?
  • Should I see a dermatologist, plastic surgeon, gastroenterologist, immunologist or another specialist?

Additional Common Questions

What’s the difference between ecthyma gangrenosum and pyoderma gangrenosum?

Ecthyma gangrenosum is a rare skin infection typically caused by Pseudomonas bacteraemia found in water and soil. Ecthyma gangrenosum causes lesions that can kill surrounding tissue (necrosis). It most commonly affects people with a weak or damaged immune system (immunocompromised).

Like ecthyma gangrenosum, pyoderma gangrenosum also causes skin lesions. Medical experts aren’t sure what causes pyoderma gangrenosum. Autoimmune diseases may cause pyoderma gangrenosum, but pyoderma gangrenosum doesn’t primarily affect those who are immunocompromised.

Are there different types of pyoderma gangrenosum ulcers?

There are four types of pyoderma gangrenosum ulcers:

  • Classic pyoderma gangrenosum: Painful ulcers that typically affect your legs.
  • Atypical or bullous pyoderma gangrenosum: Blisters that typically appear on your hands. This type often appears in those who have leukemia.
  • Pustular pyoderma gangrenosum: Pus-filled blisters (pustules) that appear on your arms and legs. This type often appears in those who have inflammatory bowel disease.
  • Vegetative pyoderma gangrenosum: Ulcers that aren’t painful.

A note from Cleveland Clinic

Pyoderma gangrenosum causes small bumps on your skin that can quickly develop into large ulcers. This condition can be difficult to diagnose, and even after a diagnosis, it may take some time for your symptoms to heal. You’ll also have to be careful to avoid any trauma that may cause new ulcers to develop. Severe pyoderma gangrenosum or the presence of comorbidities along with pyoderma gangrenosum may affect your life expectancy. If you have an autoimmune disease and start developing sores that grow quickly, contact your healthcare provider right away.

Medically Reviewed

Last reviewed by a Cleveland Clinic medical professional on 05/13/2022.

Learn more about our editorial process.

Appointments 216.444.5725