Antiplatelet drugs prevent platelets from sticking together and decrease your body’s ability to form blood clots. These medications are used to treat, and may help prevent, heart attack and stroke. Aspirin is the most commonly used antiplatelet drug. The main risk associated with antiplatelet therapy is excessive bleeding.
Antiplatelet drugs are medications that prevent blood clots from forming. They work by stopping your platelets from sticking together. Antiplatelet drugs are used to avoid blood clots, which can cause heart attacks and strokes.
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Antiplatelets prevent your platelets from clumping together to form a clot.
Blood is made up mostly of:
When your body has an injury, platelets stick or clump together to make a clot. Clots are your body’s natural way of stopping bleeding. For example, when you have a deep cut on your skin, a clot will eventually form to slow and then stop bleeding.
Both anticoagulants and antiplatelets reduce or prevent clotting. But they work in different ways.
Antiplatelets interfere with the process of platelets binding together. Anticoagulants, also called blood thinners, interfere with proteins in your blood that are involved with clotting.
Examples of anticoagulants include heparin, warfarin, apixaban (Eliquis®) and rivaroxaban (Xarelto®).
Blood clots are an important and natural way your body protects itself. But blood clots in your bloodstream can cause heart attack and stroke. This is more common in people with certain medical conditions, such as:
The most commonly used antiplatelet is aspirin, but other kinds include:
Most antiplatelet drugs are pills that you swallow (oral), but some are given intravenously (injected into a vein).
You can take oral antiplatelet medications with or without food. If they upset your stomach, try taking them with food.
If you miss a dose, take it as soon as you remember. But don’t take two doses close together, and never take a double dose.
It’s essential to take antiplatelets exactly as prescribed. Never stop taking the medication (including aspirin) without talking to your healthcare team.
Antiplatelet drugs are sometimes used to prevent blood clots, heart attacks and strokes, but are primarily used to prevent the recurrence of blood clots after a heart attack or stroke. They can also help relieve symptoms such as chest pain, poor circulation and shortness of breath.
The main risk with antiplatelet drugs is excessive bleeding. The drugs prevent all clots, including ones your body may need. For example, if you have internal bleeding or a wound on your skin, it may bleed so much that it becomes dangerous.
Before you start antiplatelet therapy, talk to your healthcare team about this risk. For example, discuss safety at home so you’re less likely to fall or cut yourself. Carefully review any other medical conditions that can cause bleeding.
If you take too many antiplatelet pills, it can be life-threatening. Never take more than what your healthcare provider prescribed.
Common side effects of antiplatelet therapy include:
Some side effects can be signs of serious problems. If you have any of the following symptoms, contact your healthcare provider:
Antiplatelet drugs can interact with other medications. Make sure your healthcare providers know about all the medications you take, including:
If you have questions about antiplatelet drug interactions, talk to your healthcare team, including your pharmacist.
Most antiplatelet drugs are long-term medications. Never stop taking antiplatelet medication or change the dose without talking to your healthcare provider.
Your healthcare provider may tell you to stop taking antiplatelet drugs temporarily before dental procedures or surgery. You also may have to stop taking them if you’re at risk of falling (for example, if you have balance problems).
People with certain conditions shouldn’t take antiplatelets, including those who:
A note from Cleveland Clinic
Antiplatelets are medications that prevent platelets from sticking together and forming blood clots. They’re a common treatment for people at risk of heart attack or stroke. The major risk with antiplatelet therapy is excessive bleeding. If you’re taking antiplatelet drugs, report any possible bleeding complications to your healthcare provider.
Last reviewed by a Cleveland Clinic medical professional on 05/05/2022.
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