Angelman syndrome is a rare condition that affects your child’s speech, development and movement. Seizures are common. Children are usually very expressive — they may smile and laugh often or get excited easily. While this condition doesn’t have a cure, treatment options can help your child manage symptoms throughout their life.
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Angelman syndrome is a rare genetic condition that affects your child’s development, speech, balance and movement. In some cases, it may cause seizures.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
If your child has this condition, you’ll notice that they’re typically in a good mood more often than usual. They might smile frequently and laugh a lot. When they’re excited, they may make hand-flapping motions. Seeing your child happy and laughing might make you happy, too. It could feel strange to think that your child’s good mood could be a sign of a health condition.
Other signs and symptoms may appear as your child gets older. You may pick up on developmental delays, like not saying their first word before their first year. Also, seizures could start between their second and third birthdays.
This condition isn’t life-threatening and shouldn’t affect your child’s life expectancy, but it can be alarming for new parents. Your child will have some challenges with movement, speech and their development as they get older. But treatment options are available to help them manage these symptoms throughout their life.
Angelman syndrome is rare. It affects approximately 1 in 12,000 to 20,000 people.
Common symptoms of Angelman syndrome may include:
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Other symptoms may include:
These symptoms, or characteristics, vary from person to person and with age.
Common facial features of Angelman syndrome may include:
These features may be more pronounced in adults with Angelman syndrome.
A genetic variant of the UBE3A gene causes Angelman syndrome. This gene provides instructions to make an enzyme called ubiquitin protein ligase E3A, which regulates how your nervous system works. Any loss or damage to this gene causes symptoms of Angelman syndrome.
You inherit one copy of the UBE3A gene from each biological parent. Both copies of this gene are “turned on” (active) in many of your body’s tissues. But in certain areas of your brain, only the copy inherited from your birthing parent (maternal copy) is active. If the maternal copy of the UBE3A gene is lost or damaged for any reason, you’ll have no active copies of the gene in some parts of your brain. This can affect how your nervous system functions.
Some cases of Angelman syndrome are the result of a yet-to-be-identified genetic variant that isn’t the UBE3A gene.
Most cases aren’t inherited and happen randomly, without any history of the condition in your biological family.
The characteristic symptoms of Angelman syndrome aren't usually apparent at birth. Healthcare providers typically diagnose it in children between one and four years of age. But providers can sometimes identify the condition during pregnancy.
Noninvasive prenatal screening (NIPS) may diagnose Angelman syndrome before birth. NIPS is a method of determining the risk that your baby will be born with certain genetic conditions. This testing analyzes small fragments of DNA that are circulating in a pregnant person’s blood.
Your provider will usually diagnose Angelman syndrome if your child misses developmental milestones for their age. Examples of missed developmental milestones include not saying their first words or not taking their first steps as expected. Your child’s provider will also look for common symptoms or characteristics of the condition.
Testing confirms a diagnosis. Your child’s provider may offer genetic testing that identifies changes to the UBE3A gene. Other types of tests may be necessary to rule out conditions with similar symptoms.
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In some cases, a misdiagnosis is possible because Angelman syndrome symptoms closely resemble those of other conditions like:
Genetic testing and other types of testing are very important to make an accurate diagnosis.
There’s currently no cure for Angelman syndrome. But treatment is available to help your child manage symptoms. This may include:
Your child’s provider will recommend treatment options specific to your child’s symptoms and needs. Treatment is individualized for each person.
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To help take care of your child with Angelman syndrome, follow their healthcare provider’s instructions. This should include:
Children with Angelman syndrome will likely need help with daily tasks throughout their lives. Your child’s care team can answer questions and offer support. They also might be able to recommend a local or online support group.
If your child has Angelman syndrome, they’ll need to see their healthcare team regularly. This is to make sure their treatment and therapies are working. Let their provider know if you notice new or worsening symptoms. Visit the emergency room if your child has a seizure for the first time.
If your child has Angelman syndrome, it may be helpful to ask their healthcare provider the following questions:
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Angelman syndrome can’t be prevented because it happens due to random genetic changes during fetal development. In most cases, this happens without a known cause.
It’s rare, but some people inherit this condition. If you plan on having a biological child, talk with your healthcare provider about genetic counseling to understand your risk of having a child with a genetic condition or a condition that can be caused by an inherited genetic variant.
Many people diagnosed with Angelman syndrome have a typical life expectancy. This means that having Angelman syndrome doesn’t mean someone will die sooner than someone without it. The severity of symptoms varies for each person. Complications from severe seizures and injuries after falls may be life-threatening. Your child’s care team will offer treatments to keep your child safe to prevent these outcomes.
There are many factors that your child’s healthcare provider will consider when evaluating your child’s outlook. You can expect that your child will have some mobility, speech and developmental delays as they grow. But your child will still be able to participate in activities, play and learn with other kids their age.
Some adults with the condition can live independently, while others need supportive care as they get older. Their provider is the best person to ask about what you can expect in the years to come.
You might feel stressed or overwhelmed to learn that your child’s frequent smile and laughter are actually characteristics of an underlying genetic condition. But your little bundle of joy will still be smiling and giggling after an Angelman syndrome diagnosis. It’s important to follow up with their providers regularly to make sure your child is on track to meet developmental milestones for their age at a pace that’s right for their needs. Your child’s care team will be with you every step of the way. Don’t hesitate to ask questions to learn more about the condition and what you can expect for their future.
When your child has a neurological condition, you want them to have the best care. At Cleveland Clinic Children’s, we offer compassionate, personalized treatment.
Last reviewed on 04/18/2025.
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