Brugada Syndrome


What is Brugada syndrome?

Brugada syndrome is a condition that causes an abnormal heart rhythm in the heart's lower chambers (ventricles). This irregular heartbeat can cause fainting (syncope) and lead to sudden cardiac death (SCD).

Brugada syndrome is a rare disease that is inherited (genetic) from at least one parent. It was first discovered in 1992. A lot has been learned about the condition since then, but there are still many unanswered questions. Researchers continue to study Brugada syndrome and test new treatments.

Symptoms and Causes

What are the symptoms of Brugada syndrome?

Symptoms of Brugada syndrome can include:

  • Ventricular tachyarrhythmia (a fast, irregular heart rhythm that begins in the lower chambers of the heart)
  • Fainting (syncope)
  • Heart palpitations (can feel like a fluttering or a flip-flopping in the chest)
  • Atrial fibrillation (a fast, irregular heart rhythm that begins in the upper chambers of the heart)
  • Cardiac arrest (this may be the first symptom)

The symptoms of Brugada syndrome are similar to many other conditions. It is important to see a doctor to find out what is causing the symptoms.

Many people with Brugada syndrome do not have any symptoms. Sometimes the condition is found during an electrocardiogram (ECG). An ECG is a recording of the heart’s electrical activity. People with Brugada syndrome often have a recognizable pattern (Brugada pattern) on the ECG printout.

What causes Brugada syndrome?

Brugada syndrome is often caused by a genetic mutation. The defect changes the way the heart's ion channels work (a problem called a channelopathy).

Diagnosis and Tests

Do You Need to be Screened for Brugada Syndrome?

Brugada Syndrome is a medical condition that can be passed on from generation to generation. It is important for you to be screened for this condition if you have a first-degree relative with Brugada Syndrome. First-degree relatives are your parents, siblings and children.

The first step is to tell your doctor that you have a family history of this condition. He or she may want to do diagnostic tests to check your heart. If these tests are positive, you should be seen by a cardiologist who is familiar with this condition.

How is Brugada syndrome diagnosed?

Your doctor will perform a physical examination, listen to your heart and order tests. Tests used to diagnose Brugada syndrome include:

  • 12 Lead Electrocardiogram (ECG) – This test records the electrical activity that makes the heart beat. The doctor can check for a Brugada pattern.
  • ECG with medication – Brugada syndrome is caused by changes in the heart’s ion channels, so before doing an ECG, your doctor may give you medication that helps the Brugada pattern "show up" on the ECG print-out.

Based on your ECG results, you may also have:

  • Electrophysiology (EP) testing – Catheters are placed inside the heart through a patient’s femoral (leg) veins. These catheters are able to measure electrical activity from inside the heart. The test is used very selectively and only in patients whose diagnosis is unclear after earlier tests.
  • Lab tests – Used to check for a normal potassium-calcium balance and to rule out other causes of an abnormal heart rhythm.
  • Genetic testing – To confirm a specific gene mutation that indicates Brugada syndrome. Other family members may want to be tested for this mutation.

Management and Treatment

What treatment is available for patients with Brugada syndrome?

If you have Brugada syndrome and a history of ventricular arrhythmias or an aborted SCD, you are considered to be high risk. Your doctor will likely recommend that you get an implanted cardiac defibrillator (ICD).


Who is at risk of having Brugada syndrome?

Brugada syndrome is more common in males than females. In fact, men are 8 to 10 times more likely than women to have the condition. All patients with a family history of SCD or Brugada syndrome should be screened for the disease.

Outlook / Prognosis

What is the outlook for patients with Brugada syndrome?

People with Brugada syndrome who have symptoms but are not receiving treatment have a high risk of SCD. Patients without symptoms and with a normal ECG at baseline have a much lower risk of SCD.

Living With

Do patients with Brugada syndrome need special care?

If you have been diagnosed with Brugada syndrome, you should be evaluated and treated by an experienced team that includes several different types of specialists. This approach helps ensure that you get the best possible care. The team should include the following:

  • Electrophysiologist - A doctor who specializes in diagnosing and treating patients with heart rhythm problems.
  • Genetic counselor - A specialist who studies genetic patterns to identify gene defects that can cause problems.
  • Primary care physician – Your "regular" doctor who can provide general follow-up care and monitor your medications.


Doctors Who Treat

To learn more about Brugada syndrome, contact us or call the Miller Family Heart, Vascular & Thoracic Institute Resource & Information Nurse at 216.445.9288 or toll-free at 800.289.6911. We would be happy to assist you.

The Inherited Arrhythmia Clinic specializes in treating patients and family members with inherited arrhythmias, such as Brugada Syndrome. To make an appointment, please call toll-free 800.659.7822 (Cardiology Appointments) or schedule online with the Request an Appointment option. If you choose to request an online appointment, select Cardiology as the Department or Specialty Area.

Doctors vary in quality due to differences in training and experience; hospitals differ in the number of services available. The more complex your medical problem, the greater these differences in quality become and the more they matter.

Clearly, the doctor and hospital that you choose for complex, specialized medical care will have a direct impact on how well you do. To help you make this choice, please review our Miller Family Heart, Vascular & Thoracic Institute Outcomes.

Cleveland Clinic Heart, Vascular & Thoracic Institute Cardiologists and Surgeons

Choosing a doctor to treat your abnormal heart rhythm depends on where you are in your diagnosis and treatment. The following Heart, Vascular & Thoracic Institute Sections and Departments treat patients with Arrhythmias:

The Heart, Vascular & Thoracic Institute has specialized centers to treat certain populations of patients:

Learn more about experts who specialize in the diagnosis and treatment of arrhythmias. For younger patients with abnormal heart rhythms:

See About Us to learn more about the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute.


If you need more information about PVCs or to make an appointment with a Cleveland Clinic heart specialist, click here to contact us, chat online with a nurse or call the Miller Family Heart, Vascular & Thoracic Institute Resource & Information Nurse at 216.445.9288 or toll-free at 866.289.6911. We would be happy to help you.

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Last reviewed by a Cleveland Clinic medical professional on 07/18/2019.



  • Zipes, Douglas et al. Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines ( , J Am Coll Cardiol 2006 48: e247-346.
  • American Heart Association. "Premature Contractions." Retrieved on March 1, 2011, from AHA website: (
  • Heart Rhythm Society. "Heart Rhythm Disorders." Retrieved on March 1, 2011, from HRS website: (
  • Heart Rhythm Society. "Skipped Heartbeats." Retrieved on March 1, 2011, from HRS website:
  • The Merck Manuals Online Medical Library. "Ventricular Premature Beats (VPB)." Retrieved on March 1, 2011, from Merck Manuals website: (

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