Neuropathic Pain

Overview

What is neuropathic pain?

Neuropathic pain can happen if your nervous system is damaged or not working correctly. You can feel pain from any of the various levels of the nervous system—the peripheral nerves, the spinal cord and the brain. Together, the spinal cord and the brain are known as the central nervous system. Peripheral nerves are the ones that are spread throughout the rest of your body to places likes organs, arms, legs, fingers and toes.

Damaged nerve fibers send the wrong signals to pain centers. Nerve function may change at the site of the nerve damage, as well as areas in the central nervous system (central sensitization).

Neuropathy is a disturbance of function or a change in one or several nerves. Diabetes is responsible for about 30% of neuropathy cases. It is not always easy to tell the source of the neuropathic pain. There are hundreds of diseases that are linked to this kind of pain.

Symptoms and Causes

What are some of the sources of neuropathic pain?

Neuropathic pain can be caused by diseases, including:

  • Alcoholism.
  • Diabetes.
  • Facial nerve problems.
  • HIV infection or AIDS.
  • Central nervous system disorders (stroke, Parkinson’s disease, multiple sclerosis, etc.)
  • Complex regional pain syndrome.
  • Shingles. (Pain that continues after your bout with shingles ends is called postherpetic neuralgia.)

Other causes include:

  • Chemotherapy drugs (cisplatin, paclitaxel, vincristine, etc.).
  • Radiation therapy.
  • Amputation, which can cause phantom pain.
  • Spinal nerve compression or inflammation.
  • Trauma or surgeries with resulting nerve damage.
  • Nerve compression or infiltration by tumors.

What are the symptoms of neuropathic pain?

Many symptoms may be present in the case of neuropathic pain. These symptoms include:

  • Spontaneous pain (pain that comes without stimulation): Shooting, burning, stabbing, or electric shock-like pain; tingling, numbness, or a “pins and needles” feeling
  • Evoked pain: Pain brought on by normally non-painful stimuli such as cold, gentle brushing against the skin, pressure, etc. This is called allodynia. Evoked pain also may mean the increase of pain by normally painful stimuli such as pinpricks and heat. This type of pain is called hyperalgesia.
  • An unpleasant, abnormal sensation whether spontaneous or evoked (dysesthesia).
  • Trouble sleeping, and emotional problems due to disturbed sleep and pain.
  • Pain that may be lessened in response to a normally painful stimulus (hypoalgesia).

Diagnosis and Tests

How is neuropathic pain diagnosed?

Your healthcare provider will take a medical history and do a physical exam. If your provider knows or suspects you have nerve injury, they will recognize typical neuropathic pain symptoms. Your provider will then try to find the underlying cause of the neuropathy and trace the symptoms.

Management and Treatment

How is neuropathic pain treated?

The goals of treatment are to:

  • Treat the underlying disease (for example, radiation or surgery to shrink a tumor that is pressing on a nerve).
  • Provide pain relief.
  • Maintain functionality.
  • Improve quality of life.

Multimodal therapy (including medicines, physical therapy, psychological counseling and sometimes surgery) is usually required to treat neuropathic pain.

Medicines commonly prescribed for neuropathic pain include anti-seizure drugs such as:

  • Gabapentin (Neurontin®).
  • Pregabalin (Lyrica®).
  • Topiramate (Topamax®).
  • Carbamazepine (Tegretol®).
  • Lamotrigine (Lamictal®).

Doctors also prescribe antidepressants such as

  • Amitriptyline (Elavil®).
  • Nortriptyline (Pamelor®).
  • Venlafaxine (Effexor®).
  • Duloxetine (Cymbalta®).

Getting a prescription from your pain specialist for anti-seizure drugs or antidepressants does not mean you have seizures or are depressed. However, it’s true that chronic pain can be made worse by anxiety or depression.

Topical treatments like lidocaine or capsaicin—patches, creams or ointments—can be used on the painful area. Opioid analgesics are less effective in treating neuropathic pain, and negative effects may prevent their long-term use.

The pain can also be treated with nerve blocks given by pain specialists, including injections of steroids, local anesthetics, or other medicines into the affected nerves.

Neuropathic pain that has not responded to the therapies mentioned above can be treated with spinal cord stimulation, peripheral nerve stimulation and brain stimulation.

Outlook / Prognosis

What is the outlook for people with neuropathic pain?

Neuropathic pain is difficult to treat completely but is usually not life-threatening. You’ll get the best results from combining rehabilitation with support for your emotional, social and mental wellbeing. You will be able to manage your pain to a level that improves your quality of life with the help of a pain specialist in using some or most of the methods mentioned above.

Last reviewed by a Cleveland Clinic medical professional on 12/07/2020.

References

  • Brain & Spine Foundation. Neuropathic Pain. (https://www.brainandspine.org.uk/information-and-support/living-with-a-neurological-problem/neuropathic-pain/) Accessed 12/29/2020
  • American Chronic Pain Association. Neuropathic Pain. (https://www.theacpa.org/conditions-treatments/conditions-a-z/neuropathic-pain/) Accessed 12/29/2020.
  • Merck Manual Consumer Version. Neuropathic Pain. (https://www.merckmanuals.com/home/brain,-spinal-cord,-and-nerve-disorders/pain/neuropathic-pain) Accessed 12/29/2020.

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