Sepsis occurs when your immune system has a dangerous reaction to an infection. It causes extensive inflammation throughout your body that can lead to tissue damage, organ failure and even death. Many different kinds of infections can trigger sepsis, which is a medical emergency. The quicker you receive treatment, the better your outcome will be.
Sepsis is your body’s extreme reaction to an infection. When you have an infection, your immune system works to try to fight it. But sometimes your immune system stops fighting the infection and starts damaging your normal tissues and organs, leading to widespread inflammation throughout your body.
At the same time, an abnormal chain reaction in your clotting system can cause blood clots to form in your blood vessels. This reduces blood flow to the different organs of your body and can cause significant damage or even failure.
Healthcare providers used to organize sepsis into three stages: sepsis, severe sepsis and septic shock. Now, they identify the condition on a more fluid scale. This scale ranges from infection and bacteremia (bacteria in your bloodstream) to sepsis and septic shock, which can lead to dysfunction of multiple organs and even death.
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
Sepsis can affect anyone, but people with any kind of infection, especially bacteremia, are at a particularly high risk.
Other people who are at a high risk include:
More than 1.7 million people in the United States receive a diagnosis of sepsis each year. There are differences in sepsis rates among different demographic groups. Sepsis is more common among older adults, with incidence increasing with each year after the age of 65 years old.
Sepsis can affect many different areas of your body, so there are many possible symptoms.
If an infection such as blood poisoning (septicemia) triggered your condition, you may develop a sepsis rash on your skin. The rash makes your skin appear red and discolored. You may see small, dark-red spots on your skin.
Other common sepsis symptoms include:
Bacterial infections are one of the most common causes of sepsis. Fungal, parasitic and viral infections are also potential sepsis causes. You can get sepsis when an infection triggers a chain reaction throughout your body causing organ dysfunction.
The infection leading to sepsis can start in many different parts of the body. Common sites and types of infections that can lead to sepsis include:
Sepsis itself isn’t contagious — you can’t spread it to other people. But you can spread the infections that can cause sepsis.
It’s very important to quickly identify people with infections that may go on to develop sepsis. There are no strict criteria to diagnose sepsis. That’s why providers use a combination of findings — from a physical exam, lab tests, X-rays and other tests — to identify the infection (blood cultures) and diagnose sepsis.
Providers may sometimes suspect sepsis at bedside using the set of sepsis criteria — a tool called quick sequential organ failure assessment (qSOFA). You may have sepsis if you have confirmed or probable infection and at least two of the following criteria:
Providers will request a number of additional tests to identify your infection and any organ damage or dysfunction. These tests may include:
Sepsis treatment needs to begin immediately. The most important concern in sepsis protocol is a quick diagnosis and prompt treatment.
If your provider diagnoses you with sepsis, they’ll usually place you in the intensive care unit (ICU) of the hospital for special treatment. You may receive the following treatment for sepsis:
Steps you can take to prevent sepsis include:
With quick diagnosis and treatment, many people with mild sepsis survive. Without treatment, most people with more serious stages of sepsis will die. Even with treatment, 30% to 40% of people with septic shock, the most severe stage of sepsis, will die.
Septic shock can cause death in as little as 12 hours.
Many people die in the months and years after surviving sepsis. But researchers don’t know if the increased risk of death is due to previously having sepsis or having an underlying health condition.
Because of this and other factors, research studies show varying rates of life expectancy after sepsis. These rates range widely but typically show that more than half of all sepsis survivors will die within five years.
With prompt treatment, many people with sepsis recover completely and return to leading normal lives. But others may experience long-term effects. You may develop complications such as:
You’re also at a higher risk of developing sepsis again. So, make sure to have any new infections treated immediately.
If you survive sepsis, you’ll more than likely need rehabilitation before returning home. Your body has been through a lot. Healthcare providers will help you restore your health, and you’ll slowly learn how to take care of yourself again. Even just sitting up and standing at first may be difficult, depending on your condition. You’ll work with a provider to get your body up and moving and practice getting yourself to the bathroom and bathing yourself. Once you’ve regained your strength and restored your mobility, you’ll be able to go home.
You’ll need to give your body, mind and soul time to recover. When you get home, you may experience some unpleasant symptoms. Physical effects may include:
Mental and emotional effects may include:
Your healthcare provider will help you develop a plan to continue in your recovery. At first, you’ll work on small, achievable goals such as bathing and dressing. You’ll work to rebuild your physical strength, but it’ll also be important to take care of your mental health. Talk to your family, friends and healthcare providers about how you’re feeling. It’ll take some time, but eventually, you should start to feel like yourself again.
A note from Cleveland Clinic
Sepsis is a life-threatening medical emergency. To avoid sepsis, make sure to get treatment for any infections immediately. If you delay treatment, a simple infection could lead to a deadly condition. If you have an infection that isn’t getting better or seems to be getting worse, seek medical care right away. Without treatment, sepsis can lead to severe complications and even death.
Last reviewed by a Cleveland Clinic medical professional on 01/19/2023.
Learn more about our editorial process.