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Nuclear Exercise Stress Test

What is a nuclear exercise stress test?

A nuclear exercise stress test is a diagnostic test used to evaluate blood flow to the heart. During the test, a small amount of radioactive tracer is injected into a vein. A special camera, called a gamma camera, detects the radiation released by the tracer to produce computer images of the heart.

Combined with exercise, the test can help determine if there is adequate blood flow to the heart during activity versus at rest.

Can I eat or drink on the day of the test?

  • Yes. However, DO NOT eat or drink anything for four hours before the test. If you must take medications, drink only small sips of water to help you swallow your pills.
  • Avoid all products that contain caffeine for 24 hours before the test. In general, caffeine is found in coffee, tea, colas and other soft drinks, most chocolate products, as well as strawberries (these contain a small amount of caffeine), as caffeine will interfere with the results of the test. Also avoid decaffeinated or caffeine-free products for 24 hours before the test, as these product contain trace amounts of caffeine.
  • DO NOT SMOKE ON THE DAY OF THE TEST, as nicotine will interfere with the results of your test.

Should I take my medications the day of the test?

Please bring a copy of all of your medications, including over-the-counter medications and supplements that you routinely take, to the test appointment.

Please follow these guidelines about taking your medications the day of the test.

Medications with caffeine: DO NOT take any over-the-counter medication that contains caffeine (such as Excedrin®, Anacin®, diet pills and NoDoz®) for 24 hours before the test. Ask your physician, pharmacist or nurse if you have questions about other medications that may contain caffeine.

If you have asthma: Your physician will tell you NOT to take theophylline (Theo-dur) for 48 hours before the test. Please plan to bring your asthma inhaler medication to the test.

If you have diabetes: If you take insulin to control your blood sugar, ask your physician how much insulin you should take the day of the test. Your physician may tell you to take only half of your usual morning dose and to eat a light meal four hours before the test. If you take pills to control your blood sugar, do not take your medication until after the test is complete. Bring your diabetes medications with you so you can take it when the test is complete. Do not take your diabetes medication and skip a meal before the test.

If you own a glucose monitor, bring it with you to check your blood sugar levels before and after your test. If you think your blood sugar is low, tell the lab personnel immediately. Plan to eat and take your blood sugar medication following your test.

If you take heart medications: DO NOT take the following heart medications on the day of the test unless your physician tells you otherwise, or unless it is needed to treat chest discomfort the day of the test:

  • Isosorbide dinitrate (for example: Dilatrate®, Isordil®)
  • Isosorbide mononitrate (for example: Imdur®, ISMO®, Monoket®)
  • Nitroglycerin (for example: Minitran®, Nitropatches®, Nitrostat®)
  • Dipyridamole (Persantine®) -- Stop taking 48 hours before the test
  • Beta Blockers (for example: metoprolol, metoprolol XL, atenolol) 

Your physician may also ask you to stop taking other heart medications on the day of your test. If you have any questions about your medications, ask your physician. Do not discontinue any medication without first talking with your physician.

What should I wear for the test?

Please wear comfortable clothes and shoes suitable for walking/jogging during the test.

What to expect during the test

Your test will take place in the Department of Nuclear Medicine located at JB-3 (in the basement of the Miller Family Pavilion). The testing area is supervised by a physician.

A nuclear medicine technologist will place an IV into a vein in your arm or hand and inject a small amount of radioactive tracer. The tracer is not a dye or contrast. After the tracer is injected, you will wait about 30 minutes before the first set of "resting" images are taken.

Then you will be asked to lie very still under the gamma camera with both arms above your head for about 15 to 20 minutes. The camera will record images that show blood flow through your heart at rest.

Next, a technician will place electrodes on your chest to monitor your EKG.

You will start walking on a treadmill or pedaling a bicycle. At regular intervals, the difficulty of the exercise will increase until you achieve the target heart rate or you develop symptoms. Then, a second dose of radioactive tracer will be injected into the IV. Your heart rate, EKG and blood pressure will be monitored throughout the test. If you are unable to achieve your target heart rate, a medication may be given to simulate exercise.

About 10-20 minutes after exercising, you will be asked to again lie very still under the camera with both arms over your head for about 15-20 minutes. The camera will record images that show blood flow through your heart during exercise. These images will be compared to the first set.

How long will the test last?

The appointment will take about three-four hours. The actual exercise part of the test lasts about seven-12 minutes.

If you weigh over 300 pounds, your test may be scheduled as a two-day test.

How do I get the results of my test?

After the cardiologist reviews your test, the results will go into your electronic medical record. Your referring physician will have access to the results and will contact you to discuss them.

Reviewed: 08/10

This information is about testing and procedures and may include instructions specific to Cleveland Clinic.
Please consult your physician for information pertaining to your testing.

Talk to a Nurse: Mon. - Fri., 8:30 a.m. - 4 p.m. (ET)

Call a Heart & Vascular Nurse locally 216.445.9288 or toll-free 866.289.6911.

Schedule an Appointment

Toll-free 800.659.7822

This information is provided by Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition.

© Copyright 2014 Cleveland Clinic. All rights reserved.

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