Wolff-Parkinson-White Syndrome (WPW)

What is Wolff-Parkinson-White Syndrome (WPW)?

Normally, the heartbeat begins at the sinoatrial (SA) node, located in your right atrium. When the SA node fires, electrical activity spreads through the right and left atria, causing them to contract. The impulses travel to the atrioventricular (AV) node, which is the bridge that allows the impulses to go from the atria to the ventricles. The impulse then travels through the walls of the ventricles, causing them to contract. The heart’s regular pattern of electrical impulses causes the heart to fill with blood and contract in a normal fashion.

Normal Heart Rhythm
Normal Heart Rhythm
Normal Sinus Rhythm
Wolff-Parkinson White (WPW)
Wolff-Parkinson White (WPW)
Wolff-Parkinson-White syndrome

WPW is an electrical abnormality in the heart that may be associated with supraventricular tachycardia (fast heart rate originating above the ventricles).

When you have WPW, along with your normal conduction pathway, you have an extra pathway called an accessory pathway. They are normal heart muscle, not specialized electric tissue, and they may:

  • Conduct impulses faster than normal
  • Conduct impulses in both directions

The impulses travel through the extra pathway (short cut) as well as the normal AV-HIS Purkinje system. The impulses can travel around the heart very quickly, in a circular pattern, causing the heart to beat unusually fast. This is called re-entry tachycardia.

Wolff-Parkinson-White Syndrome - WPW

Re-entry arrhythmias occur in about 50 percent of people with WPW; some patients may also have atrial fibrillation (a common irregular heart rhythm distinguished by disorganized, rapid, and irregular heart rhythm). Although rare, the greatest concern for people with WPW is the possibility of having atrial fibrillation with a fast ventricular response that worsens to ventricular fibrillation, a life-threatening arrhythmia.


In 1930, Wolff, Parkinson and White described a distinct electrocardiograph (ECG) pattern in healthy young people with short bursts of tachycardia. In 1933, other doctors noted the reason for this irregular rhythm was a faster passage of impulses traveling through the ventricles. In 1944, doctors confirmed the presence of extra pathways.

What causes WPW?


WPW is a congenital heart abnormality. It is the most common type of ventricular preexcitation (preexcitation: the impulses travel to the ventricle earlier than what you would expect them to if they traveled down the normal pathway through the AV node).

WPW occurs randomly in the general population, occurring in about 1 to 3 per 1,000 persons. In the general population, men have a higher incidence of WPW than women do, and there is a higher incidence of multiple accessory pathways in men.

Some cases of WPW are inherited. Parents who have accessory pathways may pass them on to their children. One paper suggested the incidence of preexcitation in first-degree relatives could be as high as 5.5 per 1,000 persons. About 7 to 20 percent of patients with WPW also have congenital defects within the heart.  

What are the symptoms of WPW?

People may first experience symptoms at any age, from infancy through adult years.

Symptoms of WPW may include one or more of the following:

  • Heart palpitations – a sudden pounding, fluttering or
  • Racing feeling in your chest
  • Dizziness – feeling lightheaded or faint
  • Shortness of breath (dyspnea)
  • Anxiety
  • Rarely, cardiac arrest (sudden death)

Some people have WPW without any symptoms at all.

How is WPW diagnosed?

WPW can only be diagnosed by reviewing an ECG (electrocardiogram), A holter or ambulatory monitor and exercise testing are also helpful in evaluating patients known to have WPW.

In the past, patients with WPW but without symptoms had been observed by a cardiologist for many years. Recently, new guidelines have been published for this group of patients. Your cardiologist may order a holter monitor or stress test to look for a persistent patter of WPW. If the WPW pattern persists, invasive electrophysiology testing is now recommended.

Your doctor will also ask you several questions:
  • Do you have symptoms?
  • Do you have a history of atrial fibrillation?
  • Do you have a history of fainting?
  • Do you have a history of sudden cardiac death or does anyone in your family?
  • Are you a competitive athlete?

The results of your diagnostic tests and the answers to these questions will help guide your therapy.

How is WPW Treated?

Treatment depends on the type and frequency of arrhythmias, associated symptoms such as syncope, and presence of structural heart disease. Patients with symptoms or tachycardias can be treated with medications or with an ablation procedure.

  • Observation - If you have no symptoms, you may not require treatment. Your doctor may choose to have regular follow-up without treatment.
  • Medications - A variety of drugs are available to treat arrhythmias. Because everyone is different, it may take trials of several medications and doses to find the one that works best for you.
    • It is important to know:
    • The names of your medications
    • What they are for
    • How often and at what times to take them

In people with WPW, whose heart rate can not be controlled with medications, ablation can improve symptoms and cure the abnormal arrhythmias. During ablation, either heat (thermal) or cryoenergy (freeze) is delivered through a catheter to “destroy” the abnormal pathways.

Doctors vary in quality due to differences in training and experience; hospitals differ in the number of services available. The more complex your medical problem, the greater these differences in quality become and the more they matter.

Clearly, the doctor and hospital that you choose for complex, specialized medical care will have a direct impact on how well you do. To help you make this choice,  please review our Miller Family Heart and Vascular Institute Outcomes

How to find a doctor if you have WPW

Cleveland Clinic Heart and Vascular Institute Cardiologists and Surgeons

Choosing a doctor to treat your abnormal heart rhythm depends on where you are in your diagnosis and treatment.  The following Heart and Vascular Institute Sections and Departments treat patients with Arrhythmias:

The Heart and Vascular Institute also has specialized centers to treat certain populations of patients:

For younger patients with abnormal heart rhythms:

See: About Us to learn more about the Sydell and Arnold Miller Family Heart & Vascular Institute.


If you need more information, click here to contact us, chat online with a nurse or call the Miller Family Heart and Vascular Institute Resource & Information Nurse at 216.445.9288 or toll-free at 866.289.6911. We would be happy to help you.

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Reviewed: 05/15

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