Myxofibrosarcoma (MFS) is a type of soft tissue sarcoma (cancer). It starts as a small lump. As the lump grows, you may have pain or swelling. Usually, healthcare providers use surgery to remove the growth. MFS is more likely to return after treatment than other types of soft tissue sarcomas. Follow-up imaging increases your chances of treating MFS early.
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Myxofibrosarcoma (MFS) is a type of soft tissue sarcoma cancer that starts in connective tissues. Connective tissues include bones, cartilage and fat that provide structure and protection around your organs. MFS often grows in your arm or leg and may look like a small lump.
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Myxofibrosarcoma may grow in connective tissues directly underneath your skin. Or it may grow in deeper connective tissues surrounding your muscles.
MFS is an aggressive tumor, meaning it spreads (metastasizes) quickly to other parts of your body. It’s more likely to grow back (recur) after treatment than some other types of cancers.
Healthcare providers use a grading scale to classify tumors. Low-grade tumors contain fewer cells that divide quickly, so these tumors grow and spread slowly. High-grade tumors have more dividing cells and grow quickly.
Myxofibrosarcoma is more common in adults over 50 and slightly more common in people designated male at birth (DMAB) than people designated female at birth (DFAB).
Other factors that can increase your risk of malignant soft tissue tumors, including MFS, include:
Myxofibrosarcoma is rare. It’s one of the most common types of soft tissue sarcomas. However, soft tissue sarcomas make up only about 2% of all cancer diagnoses.
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Experts don’t know the cause of myxofibrosarcoma. Like all types of cancer, it develops when a change happens in your cells’ DNA. This change tells your cells to multiply. As your cells multiply, they form an irregular mass called a tumor.
You may not have any symptoms of myxofibrosarcoma when it first appears. As the tumor grows, you may notice a lump beneath your skin. The lump is often painless, but you may have discomfort or swelling.
Myxofibrosarcoma may be challenging to diagnose because it can appear similar to other types of growths. Your healthcare provider may ask you if the mass has grown since you first noticed it.
To find out if you have MFS or another type of growth, your healthcare provider may perform:
Your healthcare provider surgically removes the tumor and a small amount of surrounding tissue. You may have radiation therapy before or after surgery to shrink the tumor or lower the risk of it coming back. Healthcare providers are less likely to use chemotherapy for myxofibrosarcoma than for other types of cancer.
Myxofibrosarcoma treatment depends on several factors, including:
No. Removing your arm or leg (amputation) used to be a common treatment for myxofibrosarcoma. Today, healthcare providers do everything they can to avoid amputation.
There’s no guaranteed way to prevent myxofibrosarcoma. With all types of cancer, healthy lifestyle habits may lower your risk. You may wish to avoid risk factors, such as radiation or chemical exposure, as much as possible.
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Myxofibrosarcoma is more likely to come back after treatment than other types of soft tissue sarcomas. Up to 1 in 2 people have myxofibrosarcoma return within five years of treatment.
Low-grade myxofibrosarcoma is less likely to return than higher-grade tumors. After myxofibrosarcoma treatment, you’ll have regular follow-up imaging with your healthcare provider. If the tumor does return, regularly seeing your healthcare provider increases the chances of finding and treating myxofibrosarcoma early.
Myxofibrosarcoma has better survival rates than some other types of soft tissue sarcomas. In one study, most people with myxofibrosarcoma lived five years or longer after treatment.
If you have symptoms or received a diagnosis of myxofibrosarcoma, you may want to ask your healthcare provider:
A note from Cleveland Clinic
Myxofibrosarcoma is a type of soft tissue sarcoma. It often starts as a small, painless lump. As the lump grows, it may cause discomfort or swelling. Usually, healthcare providers remove the growth with surgery. Myxofibrosarcoma is more likely to come back after treatment than other types of soft tissue sarcomas. Seeing your healthcare provider regularly can increase your chances of finding and treating MFS early if it does return.
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Last reviewed on 03/17/2022.
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