What is mpox?

Mpox is a rare disease caused by the mpox virus. It leads to rash and flu-like symptoms. Like the better-known virus that causes smallpox, it’s a member of the family called orthopoxvirus.

Mpox was discovered in 1958 when two outbreaks of a pox-like disease occurred in groups of monkeys being used for research. It’s spread mainly through human contact with infected rodents, but can sometimes be spread through skin-to-skin contact with a person who is infected. There are two known types (clades) of mpox virus — one that originated in Central Africa and one that originated in West Africa. The current world outbreak (2022) is caused by the less severe West African clade.

How common is mpox?

Mpox is rare. But the number of cases is increasing in Africa, as well as in regions that haven’t seen these infections before.

Where else is mpox found?

For decades, mpox was mostly been seen in Africa. However, it’s occasionally found in other countries, including the United States. In the spring of 2003, the first outbreak of mpox outside of Africa occurred in the U.S. A shipment of infected animals from Ghana was imported into Texas. The infected rodents spread the virus to pet prairie dogs, which then infected 47 people in the Midwest.

As international travel becomes more common, viruses that were once fairly confined to certain locations can more easily spread around the world. In the summer of 2021, a case of mpox was found in a U.S. resident who had traveled from Nigeria to the United States. Then, 2022 brought outbreaks to regions outside of Africa, including Europe, the Americas and Australia.

Who does mpox affect?

Anyone can get mpox. In Africa, most cases are among children under 15 years old. Outside of Africa, the disease appears to be more common in men who have sex with men, but there are numerous cases in people who don’t fall into that category.

Symptoms and Causes

What are the signs and symptoms of mpox?

After exposure, it may be several days to a few weeks before you develop symptoms. Early signs of mpox include flu-like symptoms, including:

After a few days, a rash often develops. The rash starts as flat, red bumps, which can be painful. Those bumps turn into blisters, which fill with pus. Eventually, the blisters crust over and fall off — the whole process can last two weeks to four weeks. You can also get sores in your mouth, vagina or anus.

Not everyone with mpox develops all the symptoms. In fact, in the current (2022) outbreak, many cases aren’t following the usual pattern of symptoms. This atypical presentation includes only a few lesions, no swollen lymph nodes, less fever and other signs of illness. You can have it and not know it. Even if you don’t show many signs of infection, you can spread still spread it to others through prolonged close contact.

How do you catch mpox?

Mpox is spread when you come into contact with an animal or a person infected with the virus. Animal-to-person transmission occurs through broken skin, like from bites or scratches, or through direct contact with an infected animal’s blood, bodily fluids or pox lesions (sores).

Mpox can spread from person to person, but it’s less common. Person-to-person spread (transmission) occurs when you come in contact with the sores, scabs, respiratory droplets or oral fluids of a person who is infected, usually through close, intimate situations like cuddling, kissing or sex. Research is ongoing, but researchers aren’t sure if the virus is transmitted through semen or vaginal fluids.

You can also get mpox by coming into contact with recently contaminated materials like clothing, bedding and other linens used by a person who is infected or an infected animal.

Diagnosis and Tests

How is mpox diagnosed?

Because mpox is rare, a healthcare provider may first suspect other rash illnesses, such as measles or chickenpox. But swollen lymph nodes usually distinguish mpox from other poxes.

To diagnose mpox, your healthcare provider takes a tissue sample from an open sore (lesion). Then, they send it to a lab for polymerase chain reaction (PCR) testing (genetic fingerprinting). You may also need to give a blood sample to check for the mpox virus or antibodies your immune system makes in defense of it.

Management and Treatment

Is mpox curable?

Mpox is usually a self-limited disease with symptoms lasting from two weeks to four weeks. Most people with mpox get better on their own without treatment. Following diagnosis, your healthcare provider will monitor your condition and try to relieve your symptoms, prevent dehydration and give you antibiotics to treat secondary bacterial infections if they develop.

There’s not currently an approved antiviral treatment for mpox. Antiviral drugs may help, but they haven’t been studied as a treatment for mpox. Several investigational antivirals with activity against mpox are available, but only as part of a research study.


How do you prevent mpox virus?

A smallpox vaccine provides protection against mpox, but its use is currently limited to clinical trials. Prevention depends on decreasing human contact with infected animals and limiting person-to-person spread. The best way to help prevent the spread of mpox virus is to:

  • Avoid contact with infected animals (especially sick or dead animals).
  • Avoid contact with bedding and other materials contaminated with the virus.
  • Thoroughly cook all foods that contain animal meat or parts.
  • Wash your hands frequently with soap and water.
  • Avoid contact with people who may be infected with the virus.
  • Practice safe sex, including the use of condoms and dental dams.
  • Wear a mask that covers your mouth and nose when around others.
  • Clean and disinfect frequently touched surfaces.
  • Use personal protective equipment (PPE) when caring for people infected with the virus.

Outlook / Prognosis

How long does mpox last?

Mpox normally takes about two weeks to four weeks to run its course. If you’re exposed to mpox, your provider will monitor you until the rash resolves.

Is mpox fatal?

The less severe West African clade is causing the current world outbreak (2022). No one has died from this outbreak to date. But mpox can lead to other problems (complications) like pneumonia and infections in your brain (encephalitis) or eyes, which can be fatal.

Living With

How do I take care of myself?

If have mpox symptoms, there are over-the-counter medications that can help you feel better, including:

  • Pain relievers and fever reducers. Medicines like ibuprofen (Advil®, Motrin®) and acetaminophen (Tylenol®) can help you feel better.
  • Oatmeal baths. Soaking in a warm bath with colloidal oatmeal can relieve the dry, itchy feeling that comes with skin rashes.
  • Isolate yourself if you’re infected. Avoid contact with others until all of your lesions have scabbed.
  • Cover single or local lesions. Use gauze or bandages to limit the spread to others and the environment.
  • Take good care. It’s important to stay home and rest when you’re sick, wear a mask around others and drink plenty of fluids.
  • Avoid contact with pets (especially rodents).

When should I see my healthcare provider?

Call your healthcare provider if you:

  • Feel sick with fever, aches or swollen lymph nodes.
  • Have a new rash or sores.
  • Have been in close contact with a person who is infected.

When should I go to the ER?

Seek medical care if you develop the following symptoms:

  • Trouble breathing.
  • New or worsening chest pain.
  • Stiff neck.
  • Are confused or can’t think clearly.
  • Difficulty speaking or moving.
  • Loss of consciousness.
  • Seizures.

Frequently Asked Questions

What is the difference?

Mpox vs. chickenpox

Although they both cause skin rashes, different viruses cause mpox and chickenpox. Mpox is an orthopoxvirus, while chickenpox is a herpes virus. Both viruses can be spread through skin-to-skin or prolonged face-to-face contact, but chickenpox is very contagious and spreads more easily than mpox. People with mpox are more likely to have swollen lymph nodes than people with chickenpox.

The rashes act differently, too. While the chickenpox rash can appear in waves, mpox sores develop at the same time. Chickenpox symptoms — including the rash — tend to get better within two weeks, while it takes two weeks to four weeks for mpox to resolve.

Mpox vs. smallpox

Smallpox and mpox are both part of the orthopoxvirus family, so they’re caused by similar but distinct viruses. Thanks to effective vaccines, smallpox was eradicated (is no longer a circulating disease) by 1980. Smallpox was very contagious and spread more easily than mpox. Mpox symptoms are similar to smallpox, but milder.

A note from Cleveland Clinic

The last two years have been incredibly challenging — the COVID-19 pandemic changed so much about the way we lived and worked. Now, just as we’re starting to ease back into regular life, we’re hearing media stories about mpox as an emerging threat. But mpox is a rare disease. It’s spread through close contact, like kissing and sex — though we’re still learning about how mpox spreads in humans. The best way to protect yourself is to avoid contact with people who are infected, wash your hands frequently and wear a face mask in crowded, indoor spaces. Early symptoms of mpox are flu-like and include fever, chills and body aches. After a few days, a rash will begin to develop. See a healthcare provider if you develop symptoms.

Last reviewed by a Cleveland Clinic medical professional on 06/17/2022.


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