Common variable immunodeficiency (CVID) is a genetic condition that causes frequent infections. In this condition, the immune system is weaker than normal. People with CVID are treated throughout their entire lives.
CVID is a genetic disorder that affects the immune system. People with this condition have low levels of antibodies (proteins that fight infections) in their blood. When the body does not have enough of these antibodies, people may experience frequent infections.
In people with CVID, infections often develop in the respiratory system, ears and sinuses. CVID can increase your risk of developing digestive problems and cancer.
CVID is a primary immunodeficiency disease (PIDD). These diseases are genetic disorders in which a person’s immune system does not work properly.
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CVID occurs in about 1 out of 25,000 people. It affects males and females in equal numbers. The condition can appear in children or teens, but usually isn’t recognized until adulthood. In most cases, a doctor diagnoses the disorder when a person is between the ages of 20 to 50.
A genetic mutation (change) causes CVID. In most cases, this genetic mutation — and CVID symptoms — develop without any apparent cause. In about 10 percent of cases, CVID is hereditary (passed down among family members).
CVID results from defects in the genes involved with the immune system. These defects cause the body to produce abnormally low amounts of a proteins called immunoglobulins, including immunoglobulin G (IgG). Low levels of IgG in the blood can make it difficult for the body to fight infections.
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Symptoms of CVID vary widely from person to person. They can range from mild to severe. Signs and symptoms of CVID include:
A doctor might look into CVID as a possible cause if you have signs of an immune disorder or have unusual reactions to vaccines.
Your doctor will ask about your family medical history and order blood tests. A sample of your blood can reveal signs of CVID, including low levels of IgG.
Blood tests can also help your doctor evaluate how well your immune system functions. Your doctor may give you a vaccine for another condition to see how your body responds to the vaccine.
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If a diagnosis of CVID is made, a doctor will prescribe immunoglobulin (IgG) replacement therapy to try to prevent infections. People who need IgG therapy have it throughout their whole lives — it’s not a one-time treatment.
IgG therapy replaces your missing immunoglobulin with antibodies from the blood of a pool of healthy donors. You’ll receive this treatment intravenously (through a needle inserted into the vein) or by an injection under the skin (subcutaneous).
Your doctor may also prescribe medications called antibiotics to treat infections related to CVID, and other medications to manage complications of CVID.
People with CVID have an increased risk of developing complications including:
You cannot prevent CVID. This condition is passed down through a family (genetic disorder) and is present throughout a person’s life.
In a small number of cases, people who have a family member with CVID are at a higher risk of developing the disorder. In most cases, doctors do not know what causes the gene mutation that causes CVID.
CVID has no cure. With ongoing treatment, many people with the disorder live active and fulfilling lives.
In some cases, complications of CVID such as lung damage or cancer may affect life expectancy. These complications appear over time. They may become life-threatening, but that process often takes years.
Contact your healthcare provider if you have frequent or repeated infections or other symptoms of CVID.
If you have common variable immunodeficiency, you may want to ask your doctor:
Last reviewed on 07/08/2019.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy