What is stomach cancer?

In stomach cancer, cancer cells usually begin on the inner lining of stomach walls and then penetrate deeper into the stomach walls as the cancer progresses. The tumor may grow to involve surrounding organs like the liver and pancreas.

Stomach cancer is one of the most common cancers worldwide, but is less commonly seen in the United States. The number of stomach cancer cases has been steadily declining over the last few decades. It has been suggested this may have been due to widespread use of refrigeration that increased access to fresh food without preservatives and bacterial contamination.

Stomach cancer may also be called gastric cancer.

What are the causes of stomach cancer?

The main cause of stomach cancer is a genetic mutation (change) in the cells of the stomach that causes the cells to grow rapidly and eventually form a tumor. There are risk factors that can increase a person’s chance of getting stomach cancer.

Some of the risk factors for stomach cancer are:

What are the symptoms of stomach cancer?

  • Nausea and vomiting
  • Difficulty swallowing
  • Heartburn
  • Loss of appetite
  • Weight loss
  • Feeling tired
  • Bloating
  • Vomiting blood (in advanced stages)

How is stomach cancer diagnosed?

There are a few different tests used to help diagnose stomach cancer. Radiologic tests like CT scan, barium swallow and MRI can help identify a problem in the stomach when the tumor is large enough. An upper endoscopy would be needed to biopsy the lesion to make the diagnosis or to detect early cancer before a mass is large enough to be seen on radiologic tests. An upper endoscopy is performed by inserting a thin tube with a tiny camera through the mouth and into the stomach. The tumor is found and biopsies are obtained from it. To find out how much of the stomach wall a tumor involves and help assess the “stage” of the cancer, many times your doctor will order an endoscopic ultrasound. An endoscopic ultrasound uses a special type of endoscope that has an ultrasound probe that is placed in the stomach through the mouth. The ultrasound probe is able to look through the surface of the stomach lining to the stomach wall beyond and see how much of the stomach is involved by the tumor.

How is stomach cancer treated?

In the early stages when the cancer is limited to the superficial layers of the stomach, the cancer can be removed through an upper endoscopy performed by a gastroenterologist. Many times, surgery can be avoided. The tumor is dissected from the rest of the gastric wall and removed through the mouth. The name of this technique is endoscopic submucosal dissection or ESD for short.

Once the tumor invades beyond the superficial layers of the stomach, surgery will be required to remove the stomach and connect the esophagus to the small intestines to allow for digestion. Radiation therapy uses high-powered beams of energy to kill cancer cells. Chemotherapy uses chemicals to kill the cancer cells. These treatments are generally combined. There are also a few types of drugs that can be used to treat stomach cancer. Treatment depends on the severity of the cancer and is decided upon by a doctor after diagnosis.

How can stomach cancer be prevented?

The best way to prevent stomach cancer is by eating a healthy diet that is high in fruits and vegetables and low in salts and red meats. It is recommended that people maintain a healthy weight and practice good exercise habits. Avoid smoking because it increases your risk for stomach cancer as well as many other cancers.

What is the outlook for people with stomach cancer?

The outlook for stomach cancer can be very different depending upon the stage of the cancer. People in the early stages have a much greater rate of survival than those at a later stage. If stomach cancer is found in its earliest stage and can be removed with an endoscope, the five-year survival rate is higher than 90%. If the cancer is found after it has spread to areas surrounding the stomach, the five-year survival rate is 28%. If the cancer has spread to areas beyond those surrounding the stomach, the five-year survival rate is 4%.


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This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. This document was last reviewed on: 5/27/2015…#15812