Cleveland Clinic Florida's Brain Tumor Center uses a multidisciplinary approach to diagnose and treat patients with a wide range of brain tumors. The center focuses on the treatment of primary and metastatic brain tumors, and their effects on the nervous system.

Our centers continually seek to enhance brain tumor care through multiple tumor board meetings including brain and pituitary tumor boards. Neurosurgeons, neuro-oncologists, neuroradiologists, radiation oncologists, pathologist, endocrinologists and neuropsychologists review the complex cases at the multidisciplinary Brain and Pituitary Tumor Boards to determine whether surgery, radiation therapy, chemotherapy or a combination will be most effective for a given patient.

Each case is presented and discussed in detail to provide our patients with individualized recommendations and options. With patient care goals in mind, we work to identify the most effective tumor treatments, enabling our patients to enjoy the best possible quality of life.

Every member of Cleveland Clinic Florida’s Brain Tumor Center is dedicated to continuous collaboration and innovation, optimizing patient outcomes. Through this quality and patient safety-focused program, we strive to create an unparalleled treatment experience for our patients.

Minimally Invasive Cranial and Pituitary Surgery Program

The Minimally Invasive Cranial and Pituitary Surgery Program within the Brain Tumor Center uses the latest technology and a multidisciplinary team approach to provide state-of-the-art minimally invasive treatment options for brain and pituitary pathologies.

Vestibular Schwannoma (Acoustic Neuroma) Program 

Vestibular Schwannoma Program within the Brain Tumor Center uses a multidisciplinary approach to manage patients with a vestibular schwannoma (acoustic neuroma). The program goal is to provide comprehensive evaluation, plan and a wide range of treatment options. Each case is presented and discussed in detail between neurosurgeons, neurootologists and radiation oncologists to provide our patients with individualized recommendations and options.

What We Treat

What We Treat

Our neurosurgical team is focused on treating the most complex medical and surgical conditions including malignant and benign brain tumors, skull base tumors. Through state-of-the-art technologies and treatments, the Brain Tumor Center and Minimally Invasive Cranial and Pituitary Surgery Program’s neurosurgeons are able to safely remove complex and difficult to access brain and skull base tumors. 

Minimally Invasive Cranial and Pituitary Surgery Program

Specialists in the Minimally Invasive Cranial and Pituitary Surgery Program are focused on treating the most complex tumors and pathologies through minimally invasive surgical approaches. Minimally invasive surgery allows for the safe removal of tumors or treatment of pathologies in the brain and skull base with minimal damage to the surrounding areas.

We offer minimally invasive treatments for the following conditions:

Benign and Malignant Tumors:

Other Pathologies:

The technology and treatments we use in our minimally invasive program are state-of-the-art and designed for the best possible outcomes.

Laser Interstitial Thermal Therapy (LITT)

Laser interstitial thermal therapy (LITT) transmits heat to treat brain tumors from the inside out. With the robotic NeuroBlate™ system, the surgeon can direct and monitor the effects of the laser beam, thus sparing surrounding healthy tissue. Unlike conventional open surgery, this therapy is minimally invasive. It takes place with the patient in a 3 Tesla MRI machine because the laser system is guided, positioned and monitored with MRI.


Cleveland Clinic Florida’s Neurological Center manages the most common to the most complex disorders of the brain and central nervous system. Through complete integration of services with Cleveland Clinic’s Neurological Institute in Ohio, as well as the Lou Ruvo Center for Brain Health in Las Vegas, we are committed to making access to the most advanced neurological care convenient for all patients. Collaboration with our colleagues allows us to leverage our collective expertise to optimize clinical decision-making, drive quality improvement and advance research.

This Robot is designed to increase the safety and reliability of various neurological procedures without compromising established surgical protocol, the ROSA® 3.0 is an integrated multi-application console that acts as a reliable and accurate surgical assistant.

Tubular Retraction System for deep seated Brain Tumors

Deep-seated brain tumors and blood clots are often considered inoperable because of the risk of damaging the delicate areas surrounding them. However, the advanced tubular retractor system is helping surgeons offer hope to patients with such inoperable brain tumors and clots.

Using imaging to precisely map the location of the tumor or clot before and during surgery, this device assists neurosurgeons in working between the natural folds and neural structures in the brain, helping them minimize damage to surrounding brain tissue. The tumor or clot can then be safely removed through a small opening in the skull.

Endoscopic Surgery for Brain, Skull Base and Pituitary Tumors

Surgical procedures using an endoscope, a long thin tube that can be inserted directly into a small incision in the body or through the nostrils, allow neurosurgeons to reach the brain, skull base or pituitary gland through a minimally invasive approach.

Endoscopic surgery is an innovative, safe, effective and collaborative way to treat pituitary adenomas and other skull-base tumors like meningioma, craniopharyngioma, chordoma, and chondrosarcoma, as well as intraventricular tumors and cysts.

Our multidisciplinary team of neurosurgeons and otolaryngologists (ENT) have expertise in the endoscopic approach to treatment of such tumors.

Surgically targeted radiation therapy (STaRT) (GammaTile Program)

Surgically targeted radiation therapy (STaRT) provides immediate, dose-intense treatment at completion of resection. The radiation source consists of a bioresorbable, flexible collagen tile that is placed within the brain immediately after a tumor is removed. GammaTile begins targeting tumor cells immediately. There is no need to wait for wound healing before starting radiation treatment. Tumor resection plus local targeted radiation therapy extends local recurrence-free survival with minimal complications, reduced patient burden, and assured compliance. Patients with recurrent glioblastomas, high grade meningiomas and brain metastases could be candidate for this new modality.

Minimal Access Craniotomy with Awake Functional Mapping and Fiber Tractography for Gliomas

Managing gliomas, the most common type of malignant brain tumor, requires a multidisciplinary approach, which includes surgery, radiotherapy, and chemotherapy. Using awake functional mapping and fiber tractography during surgery helps neurosurgeons more precisely locate the tumor and safely remove it while sparing the functional surrounding areas of the brain.

Functional magnetic resonance imaging (fMRI) is a non-invasive pre-surgical imaging tool that can be utilized when planning for resection of brain tumors or vascular lesions. This information along with fiber tractography of the brain bundles can be integrated into the intraoperative navigation system and microscope to prevent any injury to the area.

3D Exoscope System:

The 3D Exoscope system is an alternative to the operative microscope for performing many cranial procedures. Exoscope optical technology overcomes prior limitations related to visualization during fine surgical procedures, especially brain tumor surgery. Imaging hardware with higher resolutions can produce sharper, brighter, and higher quality images. Using this optic system, the surgeon is able to operate in a relatively neutral position using 3D 4K visualization. It is like a real-time surveillance image as the surgeon operates on the brain.

Fluorescence-guided surgery:

Fluorescence-guided surgery for brain tumors is a technique that allows for intraoperative delineation between diseased and normal brain. Using an advanced neurosurgical microscope, the surgeon can more easily identify the main tumor mass in addition to area of invaded tumor cells outside of the tumor tissues thus improving maximal safe resection. 5-ALA (5-aminolevulinic acid) has enabled surgeons to achieve a significantly higher rate of complete resections of malignant gliomas as compared to conventional white-light resections.

CT guided Balloon Compression for treatment of Trigeminal Neuralgia

There are currently a variety of treatment options that can help manage symptoms and reduce pain. Patients who do not respond to medication therapy or whose condition worsens over time may be candidates for surgery. Other than classic treatment with microvascular decompression that we offer at our center, we also offer minimally invasive CT-guided balloon compression of the trigeminal nerve.

During CT-guided balloon compression, a needle is passed through the cheek to the trigeminal nerve. A catheter with a small balloon is inserted through the needle and inflated under guide of CT scan to compress the nerve, treating the pain-causing fibers. Intraoperative CT guidance for this procedure is a very unique and innovative technique offered at Cleveland Clinic Florida.

Stereoelectroencephalography (SEEG) Test

Stereoelectroencephalography (SEEG) is a minimally invasive surgical procedure that is used to identify areas of the brain where epileptic seizures originate.

Find detailed information about our services and treatments:

Types of Tumors

Types of Tumors

Cleveland Clinic Florida Brain Tumor Center serves patients from across the country and around the world. Our specialists, working in partnership with specialists from the Maroone Cancer Center, offer a full range of advanced treatment options for adults brain tumors, including surgery, chemotherapy, radiotherapy and radiosurgery, and innovative brain tumor clinical trials.

More than one million Americans are diagnosed with cancer each year. Nearly 25% of these individuals will develop metastatic brain tumors during the course of their illnesses. Though the number of patients with primary brain tumors is smaller, there is evidence that the incidence of these kinds of brain tumors is rising.

Skull Base Tumors

Lesions located in or around the base of the skull are very difficult to treat surgically due to their locations. With a multidisciplinary team approach however, our experts are better able to remove deep-seated intra- and extracranial skull base lesions, allowing patients a better quality of life. Using state of the art technology including, microscope, endoscope, 3D exoscope and advanced intraoperative monitoring our skull base trained neurosurgeons are able to approach difficult access pathologies in the base of the skull safely.


Metastatic tumors are secondary brain tumors originating from a solid organ cancer elsewhere in the body. Once considered terminal, metastatic tumors can now be controlled with aggressive management and new treatment options.


Pituitary tumors are typically benign. They can cause significant hormonal abnormalities. Pituitary tumors are typically removed surgically through a minimally invasive trans-nasal approach.

Some patients may benefit from medical treatment and hormonal replacement managed by our team of endocrinologists. Occasionally patients with pituitary tumors may need focused radiation therapy.


Primary brain tumors are those that arise within the brain itself, unlike metastatic tumors that travel to the brain from a distant site. The most common types of primary brain tumors in adults are: 

Our Doctors

Our Doctors

Appointments & Locations

Appointments & Locations

To make an appointment with a specialist from our Brain Tumor Program, please call 877.463.2010.

Virtual Visits

You can now stay connected to your healthcare team through virtual visits, using your smartphone, tablet or computer.

Why go virtual? It's an easy, convenient and secure way to see your provider face-to-face without having to leave home. This saves you travel time, parking fees and time spent in the waiting room — and you can also have a loved one or caregiver join you. If appropriate, you can also get a prescription sent to the pharmacy of your choice.

Many insurance companies cover the cost of virtual visits, so check with your insurance company ahead of time. Interested in getting started? Call your provider to find out what virtual visit options are available.


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Resources For Medical Professionals

For Medical Professionals

The Cleveland Clinic Florida Brain Tumor Center and Minimally Invasive Cranial and Pituitary Surgery Program offer clinical and research fellowships in skull base surgery.

The center is committed to train future academic leaders and clinical scientists in the subspecialties of open and endoscopic skull base surgery by providing advanced training in the overall management of patients with complex skull base and brain pathologies.

Clinical Trials

Clinical Trials

The Department of Neurology at Cleveland Clinic Florida is committed to providing our patients with the most advanced treatment options available. We continually strive to offer new research advancements including access to clinical therapeutic trials for patients diagnosed with Parkinson’s disease and other movement disorders. View a full list of clinical trials.