A New Home for Neurological Care

"This building is not just a structure but rather is wholly designed with people in mind — patients with neurological diseases, their loved ones, and the clinicians and researchers caring for them." — André Machado, MD, PhD

As people live longer, neurological conditions are becoming more common. By 2040, they’re expected to become the second leading cause of death worldwide — moving ahead of cancer. Cleveland Clinic is taking a major step forward to meet this growing need with a new home for neurological care and research.

We’ve dedicated 1 million square feet of space to this neurological home base — the largest building at our Main Campus. It's designed for diagnosing, treating and researching conditions that affect the brain, nervous system and spine.

Scheduled to open in early 2027, the building will bring our neurological providers and services together under one roof, including:

• Inpatient and outpatient services
• Advanced imaging
• Surgery and other interventional treatments
• Clinical research

Designed for the Future

We have a combined goal— to deliver the best neurological care of today and keep moving forward with new tools and technologies for tomorrow.

From patient experiences to workflow for our team, we had a lot to consider.

How did it all come to life? Our providers — including doctors, nurses and therapists — shared valuable input with us during the design process. Our nurses in particular played a crucial role in ensuring the balance between patient privacy and safety and supervision needs.

That’s how we designed a building that will stay in step with growing demand and changing technology — focusing on the digital world, distance health, discovery and patient experience.

Your experience matters

Our new building’s modern design will provide a better, more efficient experience for patients and their loved ones. But good design can do more than just make a visit easier. Features that support movement, bring services together and make spaces easier to navigate can help reduce confusion and support recovery during a hospital stay.

Our design includes:

• Open spaces and natural light from floor-to-ceiling windows
• Clear signs and directions to help you get where you need to go
• More neurology-focused services under one roof, including infusion rooms, imaging, labs, pharmacy, surgery, and physical and occupational therapy
• Easy access from dedicated valet, attached parking garage, Main Campus skyway connectors and shuttle services
• Food options that include a rotating grill, made-to-order items, premium coffee and cafe services and 24/7 grab and go

Technology that supports modern care

From integrated technology and streamlined assessments to digital connectivity, we’re taking neurological care to the next level. This new building will allow us to connect our patients with Cleveland Clinic sites across the nation and the world, including:

• Lou Ruvo Center for Brain Health in Las Vegas
• Cleveland Clinic Florida
• Cleveland Clinic Abu Dhabi
• Cleveland Clinic London

Driving discovery

New research spaces will allow our healthcare providers, scientists and engineers to work together with partners from other organizations in order to discover the tests and treatments of the future. This will strengthen the connection between patient care and research.

Built to adapt

The building's flexible, modular layouts feature easily modifiable spaces and dual-purpose exam rooms with embedded office nooks for physicians. We designed it this way so the space will be able to grow and change as needed for years to come.

The latest technology and design in our new building’s testing and treatment spaces will help us gather more information about neurological conditions. It will also allow us to deliver treatments with greater precision. Here are a few examples of what you can expect:

Assessment center

We’ve designed our new testing area to help us get a more complete picture of your neurological health before you meet with your provider. The assessment center may be a new part of your appointment and might feel like an extra step. But moving testing earlier in your visit gives you and your provider more time to talk about your results and what to expect next instead of doing tests in the exam room.

During testing, our team will use a mix of brief assessments to measure how your brain and nervous system work. You’ll also have more advanced tests that will help us look at your:

• Walking and mobility (gait assessment)
• Hand coordination (dexterity)
• Speech (voice pattern analysis)
• Thinking and memory (cognitive function)

These tests are designed to uncover changes that may not surface during a routine medical exam and give your care team information they can compare over time. And you’ll get the results on the same day.

Having this information ready before your visit helps your provider better understand what’s changing, plan your care and guide you through what comes next.

Hybrid Operating Room (OR)

We’ve built what’s anticipated to be one of the most advanced neurosurgical hybrid ORs in the U.S.

This new space combines the latest imaging and surgery technology to treat a range of conditions, including cerebrovascular procedures, spine surgeries and brain tumor operations. Having everything in one room means we won’t have to move you to another space during your procedure. This can improve safety and treatment results.

The OR will include high-quality imaging that will allow us to:

• View your brain from every angle, using pivoting and rotating 3D images for precise surgery
• Make real-time adjustments during your procedure, when needed
• Help reduce the need for more procedures later on

Amenities

Whether you’re here for testing, a medical appointment or helping a loved one, you’ll find amenities that make your time in the building easier and more comfortable, including:

• Advanced therapeutics and infusions
• Food service
• Imaging
• On-site lab
• On-site pharmacy
• Parking and valet services
• Red coats
• Shuttle services
• Skyway connections to other Main Campus buildings

Location

Opening in early 2027, you’ll find us at the corner of E. 89th Street and Carnegie Avenue.

2083 E. 89th St.
Cleveland, Ohio 44106

Building access

• Main lobby (first floor): Open Monday through Friday, 5 a.m. to 9 p.m.
• Second floor: Accessible 24 hours a day, seven days a week

"Curing brain diseases in our lifetimes is our moonshot. This new Neurological Institute building is key to our strategy of advancing research and clinical practice to reach that goal." — Imad Najm, MD