Cleveland Clinic Cancer Center (Taussig) Outcomes
Head and Neck Cancer
Outcomes After Oral Cavity and Oropharyngeal Salvage Surgery
1996-2018
Oral cavity and oropharyngeal neoplasms are a growing health problem around the globe. Worldwide, there are an estimated 354,864 cases of oral cavity cancer and 92,887 cases of oropharyngeal cancer annually. The objective of this study was to investigate outcomes following oral cavity and oropharyngeal salvage surgery.
Kaplan–Meier Analysis for Overall Survival After Oral Cavity and Oropharyngeal Salvage Surgery
1996-2018
| Number at Risk | TFRSD 0 Months | TFRSD 12 Months | TFRSD 24 Months | TFRSD 36 Months | TFRSD 48 Months | TFRSD 60 Months | TFRSD 72 Months |
|---|---|---|---|---|---|---|---|
| All | 107 | 61 | 45 | 33 | 28 | 23 | 16 |
| Oral Cavity | 77 | 47 | 34 | 24 | 21 | 19 | 13 |
| Oropharynx | 30 | 14 | 11 | 9 | 7 | 4 | 3 |
TFRSD, time from recurrent surgery date.
Kaplan–Meier Analysis for Disease-Free Survival After Oral Cavity and Oropharyngeal Salvage Surgery
1996-2018
| Number at Risk | TFRSD 0 Months | TFRSD 12 Months | TFRSD 24 Months | TFRSD 36 Months | TFRSD 48 Months | TFRSD 60 Months | TFRSD 72 Months |
|---|---|---|---|---|---|---|---|
| All | 107 | 41 | 30 | 20 | 15 | 13 | 9 |
| Oral Cavity | 77 | 33 | 24 | 15 | 13 | 12 | 8 |
| Oropharynx | 30 | 8 | 6 | 5 | 2 | 1 | 1 |
TFRSD, time from recurrent surgery date.
After oral cavity and oropharyngeal salvage surgery, adjuvant chemoradiotherapy, negative margins, negative LVSI, and lower stage were associated with a lower risk of recurrence. Only lower-stage disease was associated with improved survival. The majority of patients had feeding tubes, half underwent free tissue transfer, a third required tracheostomy, and a quarter was readmitted.
