Head and Neck Cancer

Nasopharyngeal Cancer: Incidence and Prognosis of Human Papillomavirus and Epstein-Barr Virus Association at a Single North American Institution

2000-2019

The prognostication of Epstein–Barr virus (EBV) and human papillomavirus (HPV) status in nasopharyngeal cancer (NPC) is unclear. This retrospective study analyzed NPC from 2000 to 2019.

Survival Analysis Displaying Time Until Death in Patients with Primary Nasopharyngeal Cancer

2000-2019

EBV, Epstein–Barr virus; HPV, human papillomavirus.

Survival Analysis Displaying Freedom from Progression in Patients with Primary Nasopharyngeal Cancer

2000-2019

EBV, Epstein–Barr virus; HPV, human papillomavirus.

EBV+ NPC tumors were seen in younger, healthier patients than HPV+ and EBV tumors, and there were no cases of coinfection. The association of viral status with OS was insignificant after adjusting for KPS and age.

References

Wu SS, Chen B, Fleming CW, Shah AA, Griffith CC, Domb C, Reddy CA, Campbell SR, Woody NM, Lamarre ED, Lorenz RR, Prendes BL, Scharpf J, Schwartzman L, Geiger JL, Koyfman SA, Ku JA. Nasopharyngeal Cancer: Incidence and Prognosis of Human Papillomavirus and Epstein-Barr Virus Association at a Single North American Institution. Head Neck. 2022 Apr;44(4):851-861.