Head and Neck Cancer

Adjuvant Radiation Following Clear Margin Resection of High T-Stage Cutaneous Squamous Cell Carcinoma Halves the Risk of Local and Locoregional Recurrence: A Dual-Center Retrospective Study

Although adjuvant radiation (ART) following clear margin surgery is recommended for select high-risk cutaneous squamous cell carcinomas, efficacy data are limited. The objective of this study was to evaluate the impact of ART on outcomes following clear margin surgery for high T-stage cutaneous squamous cell carcinomas.

Adjusted Cumulative Incidence Curves for Local Recurrence

BWH T2b and T3 Tumors

ART, adjuvant radiation; LR, local recurrence.

Adjusted Cumulative Incidence Curves for Locoregional Recurrence

BWTH T2b and T3 Tumors

ART, adjuvant radiation.

Adjusted Cumulative Incidence Curves for Local Recurrence

High Risk

ART, adjuvant radiation; LR, local recurrence.

Adjusted Cumulative Incidence Curves for Locoregional Recurrence

High Risk

ART, adjuvant radiation.

Adjusted Cumulative Incidence Curves for Locoregional Recurrence

Low Risk

ART, adjuvant radiation.

ART following clear margin surgery for high T-stage cutaneous squamous cell carcinomas resulted in half the risk of LR and LRR.

References

Ruiz ES, Kus KJB, Smile TD, Murad F, Zhou G, Ilori EO, Schoenfeld JD, Margalit DN, Tishler RB, Vidimos AT, Koyfman SA, Schmults CD. Adjuvant Radiation Following Clear Margin Resection of High T-Stage Cutaneous Squamous Cell Carcinoma Halves the Risk of Local and Locoregional Recurrence: A dual-Center Retrospective Study. J Am Acad Dermatol. 2022 Jul;87(1):87-94.