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Diseases & Conditions

Osteoporosis

(Also Called 'Vertebral Fractures')

What is osteoporosis?

Osteoporosis is a disease that weakens bones, making them more susceptible to sudden and unexpected fractures. Literally meaning "porous bone," it results in an increased loss of bone mass and strength. The disease often progresses without any symptoms or pain. Generally, it is not discovered until weakened bones cause painful fractures.  Most of these are fractures of the hip, wrist, and spine.

Although osteoporosis occurs in both men and women, women are four times more likely to develop the disease than men. Thankfully, there are steps you can take to prevent osteoporosis from ever occurring. Treatments can also slow the rate of bone loss if osteoporosis is present. After age 50, one in two white women, and one in four white men will have an osteoporosis-related fracture in their lifetimes. An additional 30 percent have low bone density that puts them at risk of developing osteoporosis (including African Americans). Osteoporosis is responsible for more than 2 million fractures each year, and this number continues to grow.

What causes osteoporosis?

Though the exact cause of osteoporosis is unknown, we do understand how the disease develops. Your bones are made of living, growing tissue. The inside of healthy bone resembles a sponge, this area is called trabecular bone. An outer shell of dense bone wraps around the trabecular, or spongy bone. This hard shell is called cortical bone. When osteoporosis occurs, the "holes" in the "sponge" grow larger and more numerous, weakening the internal structure of the bone. In addition to supporting the body and protecting vital organs, bones store calcium and other minerals. When the body needs calcium, it breaks down and rebuilds bone. This process, called "bone remodeling," supplies the body with needed calcium while keeping the bones strong. Up until about age 30, a person normally builds more bone than he or she loses. After age 35, bone breakdown outpaces bone buildup, resulting in a gradual loss of bone mass. In a person with osteoporosis, bone mass is lost at an accelerated rate. After menopause the rate of breakdown accelerates further.

Who is most at risk for developing osteoporosis?

There are many risk factors which, when present, increase your chance of developing osteoporosis.

  • Gender — Women over the age of 50 or postmenopausal women have the greatest risk of developing osteoporosis. Women experience rapid bone loss in the first 10 years after entering menopause.This bone loss is because menopause decreases the production of estrogen, a hormone which protects against excessive bone loss.
  • Age — Your risk for osteoporosis fractures increases as you age.
  • Race —Women of Caucasian and Asian descent are more likely to develop osteoporosis. However, African American and Hispanic women are still at risk. In fact, African American women are more likely than white women to die after a hip fracture.
  • Bone structure and body weight —Petite and thin people have a greater risk of developing osteoporosis because they have less bone to lose than people with more body weight and larger frames.
  • Family history— If your parents or grandparents have had any signs of osteoporosis, such as a fractured hip after a minor fall, you may have a greater risk of developing the disease.
  • Nutrition —You are more likely to develop osteoporosis if your body lacks sufficient amounts of calcium and vitamin D.
  • Lifestyle — People who lead sedentary lifestyles have a higher risk of osteoporosis.
  • Medications — Certain medications result in side effects that may damage bone and lead to osteoporosis. These include steroids, breast cancer treatments, and medications used to treat seizures.
  • Smoking — Smoking increases the risk of fractures
  • Alcohol use -Consumption of 1-2 drinks a day (or more) increases the risk of osteoporosis
  • Medical Conditions --Those with the following conditions should consider earlier screening for osteoporosis (this is not a complete list):
    • Overactive thyroid, parathyroid, or adrenal glands
    • History of bariatric (weight loss) surgery
    • Hormone treatment for breast or prostate cancer 
    • Eating disorders (bulimia, anorexia)
    • Organ transplant
    • Celiac disease
    • Inflammatory bowel disease
    • Missed periods
    • Blood diseases such as multiple myeloma

How can I prevent osteoporosis?

Your diet and lifestyle are two important risk factors you can control to prevent osteoporosis. Replacing lost estrogen through hormone therapy also provides a strong defense against osteoporosis in postmenopausal women.

Diet —To maintain strong, healthy bones, a diet rich in calcium is needed throughout your life.

One cup of skim or 1 percent fat milk contains 300 milligrams of calcium. Besides dairy products, other good sources of calcium are salmon with bones, sardines, kale, broccoli, calcium-fortified juices and breads, dried figs, and calcium supplements. It is best to try to get the calcium from food and drink. For those who need supplements, remember that the body can only absorb 500 mg of calcium at a time. So you should take your calcium supplements in divided doses since anything more than 500 mg will not be absorbed.

Adults 19-50 years 1,000 mg
Adult men 51-70 years 1,000 mg
Adult women 51-70 years 1,200 mg
Adults 71 years and older 1,200 mg
Pregnant and breastfeeding teens 1.300 mg
Pregnant and breastfeeding adults 1,000 mg

Vitamin D is also important because it enables the body to absorb calcium. The recommended daily allowances of vitamin D are listed below. Vitamin D can also be obtained from sunlight exposure a few times a week or by consuming fortified milk.

Recommended daily allowances:

Vitamin D Calcium
Infants 0-6 Months 400 mg 1,000 mg
Infants 6-12 months 400 mg 1,500 mg
1-3 years old 600 mg 2,500 mg
4-8 years old 600 mg 3,000 mg
9-70 years old 800 mg 4,000 mg
Over 70 years old 800 mg 4,000 mg
14-50 years old pregnant/lactating 600 mg 4,000 mg

Please ask your doctor for more detailed handouts to learn about getting the right amount of calcium and vitamin D.In some cases, your doctor might recommend higher doses of vitamin D.

Lifestyle —Maintaining a healthy lifestyle can reduce the degree of bone loss. Establish a regular exercise program and avoid excessive use of alcohol and tobacco. Exercises that make your muscles work against gravity (such as walking, jogging, aerobics, and weight lifting) are best for strengthening bones.

How can I know if I have osteoporosis?

Painless and accurate medical tests can provide you with information about your bone health before problems begin.

Bone Mineral Density tests (BMD tests), or bone measurements, also known as dual X-ray absorptiometry (DXA) scan, are X-rays that use very small amounts of radiation to determine the bone density of the spine, hip, or wrist.

Your physician can order these tests for you. All women over the age of 65 should have a bone density test. The DXA scan is done earlier for women with risk factors for osteoporosis.

Men over age 70, or younger men with risk factors, should also consider getting a bone density test.

When should osteoporosis be treated with medication?

Women whose bone density test shows T-scores of 2.5 or lower should begin therapy to reduce risk factor.Many women need treatment if they have osteopenia, which is bone weakness, but at a stage not as severe as osteoporosis. Your doctor might use the World Health Organization tool to see if you qualify for treatment based on your risk factors and bone density results. The name of this tool is called the fracture risk assessment tool (FRAX). Those who have had a typical osteoporosis fracture, such as that of the wrist, spine or hip, should also be treated (sometimes even if the bone density results are normal).

How is osteoporosis treated?

Treatments for established osteoporosis include:

  • Weight-bearing exercise
  • Calcium and Vitamin D supplements
  • Medications —
    • Estrogen therapy
    • Bisphosphonates: Fosamax® (aledronate sodium), Actonel® (risedronate), Boniva® (ibandronate),Reclast® (zoledronic acid),
    • Selective Estrogen Receptor Modulators: Evista® (raloxifene),
    • Parathyroid hormone:Forteo® (teriparatide),
    • Biologic Therapy: Prolia®(denosumab)
    • Calcitonin hormone: Miacalcin®
References:

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This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. This document was last reviewed on: 8/17/2012…#4443

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