What is rabies?
Rabies is a serious disease that is caused by a virus. It is mainly a
disease of animals, but humans can get rabies when animals infected with the
disease bite them. The virus is transmitted to humans through the infected
animal's saliva. Very rare cases occur when infected saliva gets into someone’s
eyes or mouth or into an open wound.
Infected wild animals--especially bats, but also skunks,
raccoons, foxes, and coyotes-- typically transmit the disease to humans. In the
United States, dogs rarely transmit rabies to humans; however, outside the
United States, infected dogs are the most common source of transmission to
humans. Any mammal (i.e., warm-blooded animal with fur) can get rabies. Animals
that are not mammals (e.g., birds, fish, snakes) cannot get rabies.
The number of human cases of rabies in the United States is very
low (fewer than 40 cases since 1990, according to the Centers for Disease
Control and Prevention), but as many as 40,000 people are treated each year for
possible exposure to rabies after animal bites. Worldwide, rabies kills between
40,000 and 70,000 people each year and millions of animals.
If you are bitten by an animal, you should seek medical advice about possible post-exposure treatments.
What are the symptoms of rabies?
Symptoms can appear as soon as a few days after being bitten by an infected animal. However, in most cases, symptoms may not appear until weeks or months later.
One of the most unique symptoms of rabies infection is a
tingling or twitching sensation in the muscle tissue around the area of the
animal bite. After the virus leaves the local bite area, it travels up a nearby
nerve to the brain and can cause such symptoms as:
- muscle spasms
- excessive movements
- agitation, aggressiveness
- bizarre or abnormal thoughts
- weakness, paralysis
- increased production of saliva or tears
- extreme sensitivity to bright lights, sounds, or touch
- difficulty speaking
At advance stages of the infection (when the infection spreads to other parts of the nervous system), the following symptoms can develop:
- double vision
- problems moving facial muscles
- abnormal movements of the diaphragm and muscles that control breathing
- difficulty swallowing and increased production of saliva, causing the "foaming at the mouth" usually associated with a rabies infection
How is rabies treated?
Rabies is both prevented and treated with a rabies vaccine. The rabies vaccine is made from killed rabies virus. The vaccine cannot cause rabies. Current vaccines are relatively painless and given in the arm similar to other common vaccines.
A special immune globulin can also be helpful in some cases. When it is useful; starting early is important. A medical professional can help
you determine if rabies immune globulin is appropriate for your case.
To treat rabies:
If you have been bitten by an animal or exposed to rabies, call your
doctor and go to a nearby emergency room immediately. Once there, the doctor
will clean the wound thoroughly and give a tetanus shot if you are not
up-to-date with your tetanus immunization.
The decision to treat rabies right away by beginning a series of rabies vaccine shots will be based on a number of factors. These include:
- The circumstances of the bite (whether the bite provoked or unprovoked)
- The type of animal (wild or domestic; species of animal)
- The animal's vaccination history (whether or not it is vaccinated)
- Any recommendations from local health authorities regarding the
circumstance surrounding the bite
How dangerous is rabies if it is not treated?
Rabies is almost always fatal if it is left untreated. In fact, once someone
with rabies starts experiencing symptoms, they usually do not survive. This is
why it is very important to seek medical attention right away following an
animal bite, especially if the bite is from a wild animal.
How can I prevent rabies?
People at high risk of exposure to rabies should get the rabies vaccine before they come in contact with animals that might have rabies. Such people include veterinarians, animal handlers, and all rabies health care and scientific workers. Other people should consider pre-exposure vaccination. This group includes people whose activities bring them in frequent contact with animals that could be rabid. Also, international travelers who may visit parts of the world where rabies is common should get a pre-exposure vaccine.
The pre-exposure vaccination schedule consists of three doses, given as follows:
- First dose given
- Second dose given 7 days after first dose
- Third dose given 21 days or 28 days after first dose
If the decision is made to begin the rabies vaccine shots and you have never been vaccinated against rabies:
- you should get five doses of the rabies vaccine -- first dose immediately, then additional doses 3, 7, 14, and 28 days after the first dose
- you should also get a shot of Rabies Immune Globulin at the same time as the first dose of rabies vaccine
If you have been previously vaccinated against rabies:
- you should get two doses of the rabies vaccine -- the first dose immediately, and the second dose three days later
- you do not need to get a shot of Rabies Immune Globulin
Is the rabies vaccine safe?
The risk of the vaccine causing serious harm is very small. Current vaccines
used in the United States cause fewer bad reactions than previous rabies
vaccines. Typical mild problems include soreness, redness, swelling, or itching
at the sit of the shot. Other mild problems can include headache, nausea,
abdominal pain, muscle aches, and dizziness.
More moderate to severe vaccine side effects include hives,
joint pain, and fever. Signs of a severe allergic reaction include difficulty
breathing, hoarseness or wheezing, hives, paleness, weakness, rapid heartbeat,
or dizziness. Waiting in the doctor’s office or emergency area for 30 minutes
after a vaccine will usually provide time to see if a severe allergic reaction
will occur. If you experience any moderate to severe side effects, call your
doctor right away.
What are the immediate steps I need to take in case of an animal bite?
- Wash the bite area with soap and water for 5 to 10 minutes.
- Cover the bite area with a clean bandage.
- Call your doctor and go to a nearby emergency room.
- If you know the animal’s owner, get all the information about the
animal, including vaccination status and owner's name and address. Call your
local health department, especially if the animal hasn't been vaccinated.
- If you don't know the animal’s owner or if a wild animal bites you,
immediately call your local animal control authorities to get help finding
the animal that caused the bite. The animal will need to be confined and
observed for signs of rabies.
What other steps can I take to reduce the chance of exposure to rabies?
- Make sure your pets are up-to-date with their rabies vaccines. Consider
keeping them indoors so that they are less likely to be bitten by other
animals that may be infected with rabies.
- Remind your children never to touch or feed stray dogs, cats, or other
animals wandering in your neighborhood or elsewhere. Animals infected with
rabies act differently than healthy animals (although in early stages of
rabies, they may not show any signs but can still infect you). Wild animals
may act tame or move slowly. Other signs of rabies in animals include
aggressiveness, increased drooling, problems swallowing, general sickness,
difficulty moving/paralysis, and any change from typical animal behavior.
- Notify your local animal control officers or local health authorities if
you see any animals that are behaving in a way that suggests they may have rabies.
Where can I find additional information about rabies?
You can find more information at The Centers for Disease Control and Prevention website, which is
Centers for Disease Control and Prevention. Rabies.
www.cdc.gov/rabies. Accessed September 14, 2011.
U.S. Food and Drug Administration. Precautions to Prevent Rabies. www.fda.gov/. Accessed September 14, 2011.
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This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. This document was last reviewed on: 9/12/2011...#13848