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Rabies Immune Globulin (RIG) Injection

Rabies immune globulin prevents a rabies infection. Rabies mostly affects animals but a human can get the condition by an animal bite. It causes symptoms like seizures, hallucinations and paralysis. A healthcare provider will give you this injection in a hospital or clinic setting.

What is this medication?

RABIES IMMUNE GLOBULIN (ray BEES im MYOON GLOB yoo lin) reduces the risk of rabies. It is still possible to get rabies after receiving this medication, but the symptoms may be less severe or not last as long. It works by giving your body protection until your immune system learns how to fight off the infection.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): BayRab, HyperRAB, HyperRAB S/D, Imogam, KEDRAB

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Bleeding disorder
  • IgA deficiency
  • Recently received or scheduled to receive a vaccine
  • Take medications that prevent or treat blood clots
  • An unusual or allergic reaction to immune globulin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

This medication is injected into the area around a wound or into a muscle. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. While it may be given to children as young as infants for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

  • Live virus vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

This medication can decrease the response to a vaccine. If you need to get vaccinated, tell your care team if you have received this medication within the last 4 months. Extra booster doses may be needed. Talk to your care team to see if a different vaccination schedule is needed.

This medication contains products from human blood. It may be possible to pass an infection in this medication, but no cases have been reported. Talk to your care team about the risks and benefits of this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Infection—fever, chills, cough, or sore throat

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Dizziness
  • Fatigue
  • Headache
  • Joint pain
  • Muscle pain
  • Pain, redness, or irritation at injection site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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