Complement inhibition - Part One
In this two-part podcast featuring the Cleveland Clinic Journal of Medicine article, “Complement inhibition: A whole new world,” lead author Dr. Nicholas Salupo, and senior author, Dr. Ali Mehdi, Cleveland Clinic, join moderator Dr. Narbeh Melikian, Cleveland Clinic London. The trio discusses the complement system, a central component of the innate immune system, and bridge to the adaptive immune system.
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Video content: This video is available to watch online.
View video online (https://cdnapisec.kaltura.com/p/2207941/sp/220794100/playManifest/entryId/1_3ksdw7cm/flavorId/1_5f3sgelj/format/url/protocol/https/a.mp4)
Transcript
Release Date: 5/29/26
Expiration Date: 5/28/29
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
Estimated Time of Completion: 15 minutes
Podcast Title
Complement inhibition - Part One
CME Title
Complement inhibition - Part One
CME Description
“Beyond the Pages: CCJM Podcast” takes you in depth into Cleveland Clinic Journal of Medicine articles. Through moderated interviews with the authors and article reviews by experts in the field, clinicians can have an even better understanding of clinical breakthroughs that are changing the practice of medicine and how to practically apply them in patient care.
Learning Objectives
- Provide physicians with up-to-date, practical clinical information relevant to internal medicine, cardiology, and related fields.
- Relay clinical breakthroughs that are changing medical practice and advise listeners how to apply them in daily patient care.
Target Audience
The education is designed for all clinicians.
Accreditation
In support of improving patient care, Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
American Medical Association (AMA)
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Cleveland Clinic Center for Continuing Education designates this enduring activity for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.
Activity Director and Faculty
Activity Directors
Anthony Fernandez, MD, PhD
Director, Medical and Inpatient Dermatology
W.D. Steck Chair of Clinical Dermatology
Co-Director, Center for Continuing Education
Cleveland Clinic, Cleveland, OH
Steven Kawczak, PhD, CHCP, FACEHP
Assistant Professor of Medicine, Cleveland Clinic Lerner College of Medicine of CWRU
Co-Director, Center for Continuing Education
Director, Center for International Medical Education
Staff, Center for Educational Resources
Education Institute
Cleveland Clinic, Cleveland, OH
Moderator
Narbeh Melikian, BSc, MBBS, MD, FRCP
Cleveland Clinic London, United Kingdom
Faculty
Ali Mehdi, MD, MEd
Department of Kidney Medicine, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
Nicholas Salupo, DO
Ohio University Heritage College of Osteopathic Medicine, Athens, OH; Dayton Kidney, Dayton, OH
Faculty Disclosure
In accordance with the Standards for Integrity and Independence issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Center for Continuing Education mitigates all relevant conflicts of interest to ensure CME activities are free of commercial bias.
The following faculty have indicated that they may have a relationship, which in the context of their presentation(s), could be perceived as a potential conflict of interest:
Anthony Fernandez, MD, PhD
| Company | Relationship |
|---|---|
| Boehringer Ingelheim, UCB, Inc. | Consulting |
| Bristol-Myers Squibb Co. | Consulting; Teaching and Speaking |
| Pfizer, Inc. | Awarded a grant to fund a medical dermatology fellowship position; Research |
| UCB, Inc. | Consulting |
| Novartis | Consulting (Ended: 08/01/2024); Teaching and Speaking |
| Alexion | Research |
| Mallinckrodt Inc. | Consulting; Teaching and Speaking |
| Abbvie Pharmaceuticals | Consulting; Advisor or review panel participant; Teaching and Speaking |
| Castle Biosciences | Research |
| Kyowa Kirin | Teaching and Speaking |
| Biogen Inc. | Consulting; Teaching and Speaking |
| Company | |
| Boehringer Ingelheim, UCB, Inc. | |
| Relationship | |
| Consulting | |
| Bristol-Myers Squibb Co. | |
| Relationship | |
| Consulting; Teaching and Speaking | |
| Pfizer, Inc. | |
| Relationship | |
| Awarded a grant to fund a medical dermatology fellowship position; Research | |
| UCB, Inc. | |
| Relationship | |
| Consulting | |
| Novartis | |
| Relationship | |
| Consulting (Ended: 08/01/2024); Teaching and Speaking | |
| Alexion | |
| Relationship | |
| Research | |
| Mallinckrodt Inc. | |
| Relationship | |
| Consulting; Teaching and Speaking | |
| Abbvie Pharmaceuticals | |
| Relationship | |
| Consulting; Advisor or review panel participant; Teaching and Speaking | |
| Castle Biosciences | |
| Relationship | |
| Research | |
| Kyowa Kirin | |
| Relationship | |
| Teaching and Speaking | |
| Biogen Inc. | |
| Relationship | |
| Consulting; Teaching and Speaking |
Ali Mehdi, MD
| Company | Relationship |
|---|---|
| Alexion | Teaching and Speaking; Advisor or review panel participant |
| Apellis Pharmaceuticals | Teaching and Speaking |
| Calliditas Therapeutics | Advisor or review panel participant (Ended: 07/29/2024) |
| GlaxoSmithKline | Teaching and Speaking (Ended: 12/31/2025) |
| Company | |
| Alexion | |
| Relationship | |
| Teaching and Speaking; Advisor or review panel participant | |
| Apellis Pharmaceuticals | |
| Relationship | |
| Teaching and Speaking | |
| Calliditas Therapeutics | |
| Relationship | |
| Advisor or review panel participant (Ended: 07/29/2024) | |
| GlaxoSmithKline | |
| Relationship | |
| Teaching and Speaking (Ended: 12/31/2025) |
All other individuals have indicated no relationship which, in the context of their involvement, could be perceived as a potential conflict of interest.
This CME activity was produced by The Cleveland Clinic Foundation Center for Continuing Education.
CME Disclaimer
The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.
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HOW TO OBTAIN AMA PRA Category 1 Credits™ OR CERTIFICATE OF PARTICIPATION:
Log into myCME and begin the activity evaluation and print your certificate. If you need assistance, contact the CME office at myCME@ccf.org
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Recent Episodes
Complement inhibition - Part Two
In this two-part podcast featuring the Cleveland Clinic Journal of Medicine article, “Complement inhibition: A whole new world,” lead author…
Complement inhibition - Part One
In this two-part podcast featuring the Cleveland Clinic Journal of Medicine article, “Complement inhibition: A whole new world,” lead author…
Update on antiobesity medications in adults - Part Two
In this two-part podcast featuring the Cleveland Clinic Journal of Medicine article, “Update on antiobesity pharmacotherapy in adults: Curre…
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